Chad Swanson Dr Chad Swanson Academics Supervisors Reader Research subject areas Immunology Contact details chad.swanson@kcl.ac.uk
A Nuclear Export Signal in KHNYN Required for Its Antiviral Activity Evolved as ZAP Emerged in Tetrapods Lista, M. J., Ficarelli, M., Wilson, H., Kmiec, D., Youle, R. L., Wanford, J., Winstone, H., Odendall, C., Taylor, I. A., Neil, S. J. D. & Swanson, C. M., 12 Jan 2023, (E-pub ahead of print) In: Journal of virology. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1128/jvi.00872-22 RetroSnake: A modular pipeline to detect human endogenous retroviruses in genome sequencing data Kabiljo, R., Bowles, H., Swanson, C., Dobson, R., Al Khleifat, A., Marriott, H., Jones, A., Bouton, C., Quinn, J., Al-Chalabi, A. & Iacoangeli, A., 18 Nov 2022, In: iScience. 25, 11, 105289. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.isci.2022.105289 The P681H mutation in the spike glycoprotein of the alpha variant of SARS-CoV-2 escapes IFITM restriction and is necessary for type I interferon resistance. Neil, S., Lista Brotos, M., Winstone, H., Wilson, H., Ribeiro Galao, R. P., Pickering, S., Snell, L. B., Nebbia, G. & Swanson, C., 10 Oct 2022, (Accepted/In press) In: Journal of virology. Research output: Contribution to journal › Article › peer-review TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction Ribeiro Galao, R. P., Wilson, H., Schierhorn, K., Debeljak, F., Bodmer, B., Goldhill, D., Hoenen, T., Wilson, S. J., Swanson, C. & Neil, S., 19 May 2022, In: Plos pathogens. 18, 5, e1010530. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1371/journal.ppat.1010530 Minimal impact of ZAP on lentiviral vector production and transduction efficiency Sertkaya, H., Hidalgo Lumbreras, L., Ficarelli, M., Kmiec, D., Signell, A., Ali, S., Parker, H., Wilson, H., Neil, S., Malim, M., Vink, C. A. & Swanson, C., 10 Dec 2021, In: Molecular Therapy - Methods and Clinical Development. 23, p. 147-157 11 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.omtm.2021.08.008 HIV-1 sequences in lentiviral vector genomes can be substantially reduced without compromising transduction efficiency Sertkaya, H., Ficarelli, M., Sweeney, N. P., Parker, H., Vink, C. A. & Swanson, C. M., Dec 2021, In: Scientific Reports. 11, 1, 12067. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41598-021-91309-w S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies Kmiec, D., Lista, M. J., Ficarelli, M., Swanson, C. M. & Neil, S. J. D., Oct 2021, In: Plos pathogens. 17, 10, e1009726. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1371/journal.ppat.1009726 Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System Ficarelli, M., Neil, S. J. D. & Swanson, C. M., 29 Sep 2021, In: Annual Review of Virology. 8, 1, p. 265-283 19 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1146/annurev-virology-091919-104213 HIV-1 vpr induces widespread transcriptomic changes in CD4+ T cells early postinfection Bauby, H., Ward, C. C., Hugh-White, R., Swanson, C. M., Schulz, R., Goujon, C. & Malima, M. H., Jun 2021, In: Mbio. 12, 3, e01369-21. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1128/mBio.01369-21 The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2 Winstone, H., Lista, M. J., Reid, A., Bouton, C., Pickering, S., Ribeiro Galao, R. P., Kerridge, C., Doores, K., Swanson, C. & Neil, S., 12 Apr 2021, In: Journal of virology. 95, 9, e02422-20. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1128/JVI.02422-20 View all publications
9 July 2019 Scientists identify new virus-killing protein A newly identified protein called KHNYN teams up with ZAP, a known virus-killing protein, to destroy…