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Understanding and controlling cell plasticity through mediator and reprogramming
Speaker: Professor Manuel Serrano, Institute for Research in Biomedicine, Barcelona
Manuel Serrano obtained his PhD in 1991, at the University of Madrid. From 1991 to 1996, Serrano worked as a postdoctoral researcher in the team of David Beach in Cold Spring Harbor Laboratory, NY. Since 1997, Manuel works in Spain, first in Madrid, at the National Center of Biotechnology (until 2003) and at the Spanish National Cancer Research Center. In 2017, Serrano moved to the Institute for Research in Biomedicine, in Barcelona.
Manuel Serrano is recognized in the fields of tumor suppression, senescence, aging and reprogramming. In 1993, he reported the discovery of the gene p16. This gene is among the most important anti-cancer genes but also a key inducer and marker of cellular senescence. Serrano pioneered the generation of genetically-modified mice resistant to cancer. Also, the Serrano laboratory demonstrated that cellular reprogramming into pluripotency is possible within tissues in vivo (Advance of the Year 2013, by Nature Medicine). The focus of his laboratory is to apply their knowledge on senescence and reprogramming to treat degenerative diseases and aging.