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Centre for Affective Disorders

ADeSS Study


Antidepressant Advisor Study (ADeSS)

What is the study about?

For many people with depression, the antidepressants most usually prescribed by GPs are only somewhat helpful. There is an urgent need to improve the treatment of depression by providing better advice about the choices of antidepressant medications available.

What would you have to do?

Study 1 – Recruitment exclusively via selected GP surgeries

This study will test whether tailored recommendations for specific other antidepressants can be helpful to GPs and have the potential to improve depression. These recommendations will be delivered by an Antidepressant Advisor tool which we have developed for this purpose. The tool is integrated into the GP’s existing computer software.

Study 2 – Recruitment via this website

The aim of this research project is to better predict who will benefit from a specific treatment of depression using information collected via a mobile app and to determine whether the mobile app is helpful for people with mood disorders (study 2).

If you are interested in taking part in the study, we would invite you to use our Antidepressant Advisor app either on an Android or Apple mobile device, or your PC for 16 weeks. The app asks you about your depression, self-blame, side effects, and symptoms of a high in mood (weekly, 10-15 min), as well as medication (daily, 1 min).

What are the benefits?

Although, we hope that using our app will be helpful in monitoring your depression and medication, there are no documented direct benefits to you. By helping to find better ways to predict who will benefit from a specific antidepressant, it is you who will benefit the progress of research and thereby other people with depression in the future.

What are the possible disadvantages?

Some of the questions used require you to think about unpleasant emotions. This may evoke feelings such as guilt or anger. In case you feel distressed during or after taking part in the study, please tell the research team who will contact Dr Zahn or another psychiatrist/psychologist involved in the research project to arrange for further counselling over the phone.

If you would like to see if you are eligible to take part, click here to complete the online pre-assessment. Alternatively, contact us on the contact details below if you would like a pre-assessment to be conducted by phone or letter.

Study 3 – Recruitment via selected GP surgeries & this website

The aim of this study is to find better ways to predict how well a treatment works for a particular person (i.e. predicts response to treatment). We have previously found some psychological tests, brain scans, and blood tests that could be useful in predicting response to treatment. So far, no one has combined these to see whether they could be practically useful in the NHS.

If you would like to see if you are eligible to take part, click here to complete the online pre-assessment.

Watch Dr Roland Zahn being interviewed on ITV 

Further Information

Please contact either of us at the address below if you have any questions about the study.

Dr Phillippa Harrison (Trial Co-ordinator)

Project e-mail:

Telephone: 07444742274


Dr Roland Zahn (Chief Investigator)


Telephone: 02078480348

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