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Biography

Professor Grigoriadis is a cell biologist interested in how bone and cartilage tissues are formed during embryonic development and in the post-natal remodelling skeleton, and how deregulated molecular mechanisms drive metabolic bone disease, in particular skeletal cancers. 

He obtained his PhD at the University of Toronto, identifying novel multipotent skeletogenic mesenchymal stem cell populations, and received a MRC Canada Fellowship for postdoctoral work at the IMP in Vienna where he established transgenic models of bone cancer and metabolic bone disease. 

His current group at King's uses pluripotent stem cell-based approaches to understand bone/cartilage lineage commitment during development and for generating defined populations for stem cell-based therapy of bone and cartilage disorders, and is identifying signalling pathways and novel therapeutic targets involved in osteosarcoma growth and metastasis using in vivo models.