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King’s People

Professor Agamemnon (Agi) Grigoriadis

Academics

Associate Dean for Postgraduate Research

Professor of Bone and Cartilage Cell Biology.

Contact details

Biography

Professor Grigoriadis is a cell biologist interested in how bone and cartilage tissues are formed during embryonic development and in the post-natal remodelling skeleton, and how deregulated molecular mechanisms drive metabolic bone disease, in particular skeletal cancers.

He obtained his PhD at the University of Toronto, identifying novel multipotent skeletogenic mesenchymal stem cell populations, and received a MRC Canada Fellowship for postdoctoral work at the IMP in Vienna where he established transgenic models of bone cancer and metabolic bone disease.

His current group at King's uses pluripotent stem cell-based approaches to understand bone/cartilage lineage commitment during development and for generating defined populations for stem cell-based therapy of bone and cartilage disorders, and is identifying signalling pathways and novel therapeutic targets involved in osteosarcoma growth and metastasis using in vivo models.

Latest publications

In Vivo Targets of Pasteurella Multocida Toxin
Banu, A., Lax, A. J. & Grigoriadis, A. E., 15 Apr 2020, In : International Journal of Molecular Sciences. 21, 8, p. 2739-2750 2739. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.3390/ijms21082739
Binding Immunoglobulin Protein (BiP) Inhibits TNFÎ±-Induced Osteoclast Differentiation and Systemic Bone Loss in an Erosive Arthritis Model: BiP inhibits osteoclasts in an arthritis model
Zaiss, M. M., Hall, C., McGowan, N. WA., Babb, R., Devlia, V., Lucas, S., Meghji, S., Henderson, B., Bozec, A., Schett, G., David, J-P., Panayi, G. S., Grigoriadis, A. E. & Corrigall, V., 2019, In : ACR Open Rheumatology. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1002/acr2.11060
Induction of neural crest stem cells from Bardet-Biedl Syndrome patient derived hiPSCs
Barrell, W. B., Griffin, J. N., Harvey, J-L., HipSci Consortium, Danovi, D., Beales, P., Grigoriadis, A. & Liu, K. J., 21 Jun 2019, In : Frontiers in Molecular Neuroscience. 12, 139. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.3389/fnmol.2019.00139
Murine models of bone sarcomas
Jacques, C., Renema, N., Ory, B., Walkley, C. R., Grigoriadis, A. E. & Heymann, D., 1 Jan 2019, Methods in Molecular Biology. Humana Press Inc, Vol. 1914. p. 331-342 12 p. (Methods in Molecular Biology; vol. 1914). Research output: Chapter in Book/Report/Conference proceeding - Chapter. DOIs: https://doi.org/10.1007/978-1-4939-8997-3_18
Hypoxia impacts human MSC response to substrate stiffness during chondrogenic differentiation
Foyt, D. A., Taheem, D. K., Ferreira, S. A., Norman, M. D. A., Petzold, J., Jell, G., Grigoriadis, A. E. & Gentleman, E., 15 Apr 2019, In : Acta Biomaterialia. 89, p. 73-83 11 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.actbio.2019.03.002
The osteogenic potential of the neural crest lineage may contribute to craniosynostosis
Doro, D., Liu, A., Grigoriadis, A. E. & Liu, K. J., 1 Feb 2019, In : Molecular syndromology. 10, 1-2, p. 48-57 10 p. Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1159/000493106
Site-specific differences in osteoblast phenotype, mechanical loading response and estrogen receptor-related gene expression
Gharibi, B., Ghuman, M. S., Cama, G., Rawlinson, S. C. F., Grigoriadis, A. E. & Hughes, F. J., 5 Dec 2018, In : Molecular and Cellular Endocrinology. 477, p. 140-147 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.mce.2018.06.011
Small animal models for the study of bone sarcoma pathogenesis: characteristics, therapeutic interests and limitations
Jacques, C., Renema, N., Lezot, F., Ory, B., Walkley, C. R., Grigoriadis, A. E. & Heymann, D., 2018, In : J Bone Oncol. Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1016/j.jbo.2018.02.004
Recurrent rearrangements of FOS and FOSB define osteoblastoma
Fittall, M., Mifsud, W., Pillay, N., Ye, H., Strobl, AC., Zhang, L., Berisha, F., Verfaillie, A., Demeulemeester, J., Tarabichi, M., Young, MD., Miranda, E., Tarpey, PS., Tirabosco, R., Amary, F., Grigoriadis, A. E., Stratton, MR., Van Loo, P., Antonescu, CR., Campbell, PJ. & 2 others, Flanagan, AM. & Behjati, S., 3 Jun 2018, In : Nature Communications. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41467-018-04530-z
Utility of VS38c in the Diagnostic and Prognostic Assessment of Osteosarcoma and Other Bone Tumours/Tumour-Like Lesions.
Hookway, E., Orosz, Z., Uchihara, Y., Grigoriadis, A. E., Hassan, AB., Opermann, U. & Athanasou, N., 2017, In : Clin Sarcoma Res. Research output: Contribution to journal - Article

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