Dr Andre Cobb Professor Andre Cobb Academics Professor of Organic Chemistry Academic Planning Lead . Organic and Biological Chemistry Section Lead. Advanced Topics in Synthesis Module Lead. Research subject areas Chemistry Contact details +44 (0)20 7848 1744 andre.cobb@kcl.ac.uk
Development of Bifunctional Fluorescent Probes and their Application to α-Helix Labelling Flow-based bioconjugation of coumarin phosphatidylethanolamine probes: Optimised synthesis and membrane molecular dynamics studies Synthesis and Biophysical Characterization of Fingolimod Derivatives as Cardiac Troponin Antagonists Fluorescent head-labelled phospholipid coumarin bioconjugate as a chemical reporter for antioxidant protection in liposomes Crystal Structure and NMR of an α,δ-Peptide Foldamer Helix Shows Side-Chains are Well Placed for Bifunctional Catalysis: Application as a Minimalist Aldolase Mimic Enantioselective Organocatalytic Synthesis of Bicyclic Resorcinols via an Intramolecular Friedel–Crafts-Type 1,4-Addition: Access to Cannabidiol Analogues High Throughput Screen Identifies Small Molecule Effectors That Modulate Thin Filament Activation in Cardiac Muscle Synthesis of an intriguing steroidal constitutional isomer Highly Enantioselective, Organocatalytic and Scalable Synthesis of a rare cis-cis-Tricyclic Diterpenoid Organocatalytic Access to a cis-Cyclopentyl-γ-amino Acid: An Intriguing Model of Selectivity and Formation of a Stable 10/12-Helix from the Corresponding γ/α-Peptide Emergent Glycerophospholipid Fluorescent Probes: Synthesis and Applications Synthesis and antiviral activity of novel spirocyclic nucleosides High potency of lipid conjugated TLR7 agonist requires nanoparticulate or liposomal formulation Syntheses and applications of enantiopure δ-amino acids and their precursors Reversal of enantioselectivity using catalysts containing multiple stereogenic centres Construction of functionalised medium rings by stereospecific expansions of 2,3-epoxy alcohols under mild conditions 5-Pyrrolidin-2-yltetrazole as an asymmetric organocatalyst for the addition of ketones to nitro-olefins Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions Asymmetric synthesis using catalysts containing multiple stereogenic centres and a trans-1,2-diaminocyclohexane core; reversal of predominant enantioselectivity upon N-alkylation A homo-proline tetrazole as an improved organocatalyst for the asymmetric Michael addition of carbonyl compounds to nitro-olefins Targeting C-reactive protein for the treatment of cardiovascular disease Recent highlights in modified oligonucleotide chemistry Enantioselective Intramolecular Michael Addition of Nitronates onto Conjugated Esters: Access to Cyclic gamma-Amino Acids with up to Three Stereocenters Trapping of palindromic ligands within native transthyretin prevents amyloid formation Asymmetric Phase-Transfer-Catalyzed Synthesis of Five-Membered Cyclic gamma-Amino Acid Precursors Aldol reaction of butane-2,3-diacetal protected methyl glycerate Organocatalytic enantioselective construction of nitrocyclohexanes containing multiple chiral centres via a cascade reaction Mild and Rapid Method for the Generation of ortho-(Naphtho)quinone Methide Intermediates AID Enzymatic Activity Is Inversely Proportional to the Size of Cytosine C5 Orbital Cloud Organocatalytic Domino Reaction of Cyanosulfones: Access to Complex Cyclohexane Systems with Quaternary Carbon Centers Asymmetric Organocatalysis and the Nitro Group Functionality Synthesis and Antiviral Properties of Spirocyclic [1,2,3]-Triazolooxazine Nucleosides Targeted Activation of Toll-Like Receptors: Conjugation of a Toll-Like Receptor 7 Agonist to a Monoclonal Antibody Maintains Antigen Binding and Specificity Asymmetric cyclopropanation of conjugated cyanosulfones using a novel cupreine organocatalyst: rapid access to delta(3)-amino acids Asymmetric Organocatalytic Synthesis of Cyclopentane -Nitroketones Cupreines and cupreidines: an established class of bifunctional cinchona organocatalysts Stabilised alpha helical peptides: A novel platform for enhanced antisense oligonucleotide delivery View all publications
3 September 2025 Chemist awarded £1.2 million grant to design a new kind of biological catalyst Professor Andre Cobb’s EPSRC Standard Research Grant will unlock a new level of control over…