Professor Anne Ridley FRS, FMedSci, FRMS Visiting Supervisors Visiting Professor of Cell Biology Research subject areas Cell Biology Contact details anne.ridley@kcl.ac.uk
Cytoskeleton: Rho GTPases and actin cytoskeleton dynamics Effects of RhoA and RhoC upon the sensitivity of prostate cancer cells to glutamine deprivation Rnd3 interacts with TAO kinases and contributes to mitotic cell rounding and spindle positioning Calcium-RasGRP2-Rap1 signaling mediates CD38-induced migration of chronic lymphocytic leukemia cells RhoBTB1 interacts with ROCKs and inhibits invasion Inhibition of Rho-associated kinases suppresses cardiac myofibroblast function in engineered connective and heart muscle tissues IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells Hypoxia suppresses myofibroblast differentiation by changing RhoA activity Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2 The Rho GTPases in Macrophage Motility and Chemotaxis A role for Cdc42 in macrophage chemotaxis RhoE regulates actin cytoskeleton organization and cell migration RHO family proteins and signal transduction The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs 06 Biological Sciences 0601 Biochemistry and Cell Biology Regulation and Functions of RhoU and RhoV The RhoB small GTPase in physiology and disease An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration Rho GTPase signaling complexes in cell migration and invasion Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency Endothelial cell-cell adhesion and signaling Ellagitannin-rich cloudberry inhibits hepatocyte growth factorinduced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice Rnd3-induced cell rounding requires interaction with Plexin-B2 Rho GTPases: Regulation and roles in cancer cell biology: Regulation and roles in cancer cell biology Open questions: What about the 'other' Rho GTPases? The RNA-binding protein LARP4 regulates cancer cell migration and invasion RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border Regulating Rho GTPases and their regulators Anne Ridley: Networking with Rho GTPases Is there a role for IGF-1 in the development of second primary cancers? Dual inhibition of histone deacetylases and phosphoinositide 3-kinases: Effects on burkitt lymphoma cell growth and migration Rho GTPase signalling in cell migration The function of rho-associated kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells “Atypical Rho Family Members“ Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration FMNL1 promotes proliferation and migration of leukemia cells Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration The Rho GTPase RhoB regulates cadherin expression and epithelial cell-cell interaction RhoC and ROCKs regulate cancer cell interactions with endothelial cells Rho and Rap guanosine triphosphatase signaling in B cells and chronic lymphocytic leukemia Diverse matrix metalloproteinase functions regulate cancer amoeboid migration Analyzing the roles of Rho GTPases in cancer cell migration with a live cell imaging 3D-morphology-based assay Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration Rnd3 induces stress fibres in endothelial cells through RhoB RhoA, RhoB and RhoC have different roles in cancer cell migration Determining Rho GTPase activity by an affinity-precipitation assay Roles of Rho GTPases in leucocyte and leukaemia cell transendothelial migration Crossing the endothelial barrier during metastasis GTPase switch: Ras then Rho and Rac View all publications