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King’s People

Dr Charlotte Odendall

Academics

Sir Henry Dale Fellow

Contact details

Biography

The Odendall Laboratory studies both sides of host/bacteria interactions, in particular at the level of type I and III interferons. These cytokines are mostly studied for their antiviral properties but we find they have interesting functions in infections with enteric bacterial pathogens like Salmonella and Shigella. In addition, we are interested in identifying and characterising bacterial factors that block or manipulate interferon expression or signalling, and how these actions contribute to pathogenesis.

Latest publications

COVID-19 and emerging viral infections: The case for interferon lambda
Prokunina-Olsson, L., Alphonse, N., Dickenson, R. E., Durbin, J. E., Glenn, J. S., Hartmann, R., Kotenko, S. V., Lazear, H. M., O'Brien, T. R., Odendall, C., Onabajo, O. O., Piontkivska, H., Santer, D. M., Reich, N. C., Wack, A. & Zanoni, I., 4 May 2020, In : Journal of Experimental Medicine. 217, 5, e20200653. Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1084/jem.20200653
Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells
Stanifer, M. L., Mukenhirn, M., Muenchau, S., Pervolaraki, K., Kanaya, T., Albrecht, D., Odendall, C., Hielscher, T., Haucke, V., Kagan, J. C., Bartfeld, S., Ohno, H. & Boulant, S., 1 Jan 2020, In : Nature Microbiology. 5, 1, p. 181-191 11 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41564-019-0594-3
Editorial: Interferon-Î»s: New Regulators of Inflammatory Processes
Zanoni, I. & Odendall, C., 4 Sep 2019, In : Frontiers in Immunology. 10, 2117. Research output: Contribution to journal - Editorial. DOIs: https://doi.org/10.3389/fimmu.2019.02117
Host-encoded sensors of bacteria: Our windows into the microbial world
Odendall, C. & Kagan, J. C., 1 May 2019, In : Microbiology Spectrum . 7, 3, BAI-0011-2019. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1128/microbiolspec.BAI-0011-2019
Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication
Antzin-Anduetza, I., Mahiet, C., Granger, L. A., Odendall, C. & Swanson, C. M., 9 Nov 2017, In : Retrovirology. 14, 49. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1186/s12977-017-0374-1
Type III IFNS are commonly induced by bacteria-sensing TLRS and reinforce epithelial barriers during infection
Odendall, C., Voak, A. A. & Kagan, J. C., 1 Nov 2017, In : Journal of Immunology. 199, 9, p. 3271-3279 9 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.4049/jimmunol.1700250
Activation and pathogenic manipulation of the sensors of the innate immune system
Odendall, C. & Kagan, J. C., Apr 2017, In : MICROBES AND INFECTION. 19, 4-5, p. 229-237 9 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.micinf.2017.01.003
A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4
Rosadini, C., Zanoni, I., Odendall, C. M., Green, E. R., Paczosa, M. K., Philip, N. H., Brodsky, I. E., Mecsas, J. & Kagan, J., 9 Dec 2015, In : Cell Host & Microbe. p. 682-93 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.chom.2015.11.006
The unique regulation and functions of type III interferons in antiviral immunity.
Odendall, C. M., Jun 2015, In : Current opinion in virology. Research output: Contribution to journal - Article
Diverse intracellular pathogens activate type III interferon expression from peroxisomes.
Odendall, C., Dixit, E., Stavru, F., Bierne, H., Franz, K. M., Fiegen Durbin, A., Boulant, S., Gehrke, L., Cossart, P. & Kagan, J. C., Aug 2014, In : Nature Immunology. p. 717-726 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/ni.2915

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