Christopher Shaw is Professor of Neurology and Neurogenetics at the Institute of Psychiatry, Psychology & Neuroscience at King's College London.

He is Director of the Maurice Wohl Clinical Neuroscience Institute. He is also a Group Leader at UK Dementia Research Institute at King's and the former Director (2017-2022). His research group focuses on frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) with two main objectives:

1. To develop novel AAV-based gene therapy therapeutic approaches. Optimising AAV9 vectors for gene delivery into the CNS from preclinical experiments in cells and rodents up to first-in-human experimental medicine studies.
2. To map TDP-43 proteostasis in vitro using human iPSc-derived neurons: phenotypic analyses including transcriptomics, proteomics and high-content imaging in cultured motor neurons – including patient-derived iPSC and isogenic lines generated by genome editing with CRISPR/Cas9.

Key Collaborators

• Professor Ammar Al-Chalabi, King's College London
• Dr Robert H Brown Jr, University of Massachusetts
• Professor John Landers, University of Massachusetts
• Professor Siddarthan Chandran, University of Edinburgh

Key Publications

• Gkazi et al., 2019. Striking phenotypic variation in a family with the P506S UBQLN2 mutation including amyotrophic lateral sclerosis, spastic paraplegia, and frontotemporal dementia. Neurobiol Aging.
• Selvarajet al., 2018. C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity. Nat Commun.
• de Majo et al, 2018. ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function. Neurobiol Aging.
• Smith et al., 2017. Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis. Science Translational Medicine.
• Lee et al, 2017. C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity. Hum Mol Genet.

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