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Frontotemporal dementia

 

Frontotemporal dementia affects specific parts of the brain and shrinkage in these regions changes personality, language and behaviour. The personality change can be dramatic and can make it difficult for family members to cope. We have identified many genes involved and have increased understanding in how it links with motor neuron disease – two devastating diseases that can share a common genetic cause. Our discoveries provide targets needed for the development of new drug treatments and we are currently investigating potential gene therapies to remove toxic mutant genes or add missing genes.

Our major focus for the future is to develop and test gene therapies using antisense oligonucleotides and adeno-associated viral gene vectors which can either knock down toxic mutant genes or supplement deleted genes.

Our key questions:

  • How does dysfunctional transport inside the cell (between the nucleus and cytoplasm) initiate neurodegeneration in frontotemporal dementia?
  • How do the powerhouses of the cells, mitochondria, contribute to frontotemporal dementia?
  • Can gene therapies either knock down toxic mutant genes or supplement deleted genes?

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Our research

Our research

Leading the world in understanding brain function and finding new treatments for patients

What is neuroscience?

What is neuroscience?

Neuroscience is the study of the nervous system, from structure to function, in health and disease

 

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Centres

Specialist neuroscience centres, world-leading in understanding the brain at all stages of life

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World-class neuroscience facilities, including MRI, neuroimaging equipment, and King's Brain Bank

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News and events

Suffrage science

7 September 2020

The Suffrage Science Awards

The Suffrage Science awards, curated by the MRC London Institute of Medical Sciences, celebrate…