Jernej Ule is Van Geest Professor of Neurodegeneration Research at the Institute of Psychiatry, Psychology & Neuroscience at King's College London. 

Jernej leads the RNA Networks Laboratory and am the Centre Director of UK Dementia Research Institute at King’s. His group studies the importance of RNA networks in coordinating neuronal differentiation and functions, with a focus on the assembly and function of ribonucleoprotein complexes (RNPs) and their deregulation in amyotrophic lateral sclerosis (ALS).

In recent years, his research has developed new transcriptome-wide methods such as iCLIP to address the mechanisms controlling alternative splicing and localisation of RNAs in neurons, to characterise the function of several RNA-binding proteins that are implicated in ALS, and to reveal how mutations can modify RNP functions and thereby contribute to disease or evolution. They are now developing new therapeutic approaches for ALS and other neurologic diseases based on these insights.

Please see Jernej's Research Staff Profile for more detail 

Find out more about his research

• Ule Lab
• Ule Laboratory at Francis Crick Institute

Key publications

• Hallegger M et al., 2021. TDP-43 condensation properties specify its RNA-binding and regulatory repertoire. Cell. 
• Briese et al., 2019. A systems view of spliceosomal assembly and branchpoints with iCLIP. Nat Struct Mol Biol.
• Blazquez et al., 2018. Exon junction complex shapes the transcriptome by repressing recursive splicing. Mol Cell. 
• Attig et al., 2018. Heteromeric RNP assembly at LINEs controls lineage-specific RNA processing. Cell.
• Soreq et al., 2017. Major shifts in glial regional identity are a transcriptional hallmark of human brain aging. Cell Reports.

View all publications

Key collaborators

• Andrea Serio, Francis Crick Institute and King's College London
• Sonia Gandhi, Francis Crick Institute and UCL
• Pietro Fratta, Francis Crick Institute and UCL
• Sila Ultanir, Francis Crick Institute