Biography

I lead the RNA Networks Laboratory and am the Centre Director of UK Dementia Research Institute at King’s. My group studies the importance of RNA networks in coordinating neuronal differentiation and functions, with a focus on the assembly and function of ribonucleoprotein complexes (RNPs) and their deregulation in amyotrophic lateral sclerosis (ALS). In recent years, we developed new transcriptome-wide methods such as iCLIP to address the mechanisms controlling alternative splicing and localisation of RNAs in neurons, to characterise the function of several RNA-binding proteins that are implicated in ALS, and to reveal how mutations can modify RNP functions and thereby contribute to disease or evolution. We’re developing new therapeutic approaches for ALS and other neurologic diseases based on these insights.

Please see my Research Staff Profile for more detail 

Find out more about my research:

• Ule Lab
• Ule Laboratory at Francis Crick Institute

Key publications:

• Hallegger M et al., 2021. TDP-43 condensation properties specify its RNA-binding and regulatory repertoire. Cell. 
• Briese et al., 2019. A systems view of spliceosomal assembly and branchpoints with iCLIP. Nat Struct Mol Biol.
• Blazquez et al., 2018. Exon junction complex shapes the transcriptome by repressing recursive splicing. Mol Cell. 
• Attig et al., 2018. Heteromeric RNP assembly at LINEs controls lineage-specific RNA processing. Cell.
• Soreq et al., 2017. Major shifts in glial regional identity are a transcriptional hallmark of human brain aging. Cell Reports.

View all publications

Key collaborators:

• Andrea Serio, The Francis Crick Institute & King's
• Sonia Gandhi, The Francis Crick Institute & UCL
• Pietro Fratta, The Francis Crick Institute & UCL
• Sila Ultanir, The Francis Crick Institute