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Jernej Ule

Professor Jernej Ule

Van Geest Professor of Neurodegeneration Research

Research interests

  • Neuroscience

Contact details

Biography

I lead the RNA Networks Laboratory and am the Centre Director of UK Dementia Research Institute at King’s. My group studies the importance of RNA networks in coordinating neuronal differentiation and functions, with a focus on the assembly and function of ribonucleoprotein complexes (RNPs) and their deregulation in amyotrophic lateral sclerosis (ALS). In recent years, we developed new transcriptome-wide methods such as iCLIP to address the mechanisms controlling alternative splicing and localisation of RNAs in neurons, to characterise the function of several RNA-binding proteins that are implicated in ALS, and to reveal how mutations can modify RNP functions and thereby contribute to disease or evolution. We’re developing new therapeutic approaches for ALS and other neurologic diseases based on these insights.

Please see my Research Staff Profilefor more detail 

Find out more about my research:

Key collaborators:

  • Andrea Serio, The Francis Crick Institute & King's
  • Sonia Gandhi, The Francis Crick Institute & UCL
  • Pietro Fratta, The Francis Crick Institute & UCL
  • Sila Ultanir, The Francis Crick Institute

Research

London landscape
Ageing Research at King's (ARK)

Cross faculty consortium addressing ageing and healthy longevity.

synthetic-biology
RNA Biology

RNA is at the forefront of biomedical research for its central role in how information is transferred from DNA to protein. This Research Interest Group is open to all interested parties from across the University.

Crick
The Francis Crick Institute

King’s is delighted to be a founding academic partner alongside UCL and Imperial College in the Francis Crick Institute, joining the multidisciplinary research expertise from all the Partners together to deliver world-leading biomedical research.

News

King's College Hospital Chief Officers Visit Maurice Wohl Clinical Neuroscience Institute

Professor Clive Kay and Dr Leonie Penna met with School of Neuroscience researchers to learn about clinical and academic partnerships.

KCHvisit2thumbnail

New Wellcome Discovery Award to study gene regulation in autism spectrum disorder and Alzheimer's disease.

Professor Jernej Ule, Dr Laura Andreae, and Professor Ben Blencowe have received £5,443,308 for the project “Context-dependent RNA regulation and its...

synapse-neuron.x9d419a4e

New Centre Director joins UK DRI at King's College London

King’s College London welcomes Professor Jernej Ule as the new Centre Director at UK Dementia Research Institute (UK DRI) at King's

Jernej Ule

Events

27JanMMG seminar photo 780x450

The interplay of RNA structure and protein disorder in protein-RNA condensates

Seminar with Professor Jernej Ule

Please note: this event has passed.

05DecJernej Ule inagural

Professor Jernej Ule - Inaugural Lecture

Join us in celebrating Professor Jernej Ule's inaugural lecture on 'Understanding protein-RNA condensates and their disruptions in ALS'

Please note: this event has passed.

Features

Introducing Professor Ben Blencowe

I talked to Professor Benjamin Blencowe, who recently joined the Centre for Developmental Neuroscience at the School of Neuroscience (IoPPN). I asked him...

neuroscience-hero-banner-image-Cropped-1952x600

Research

London landscape
Ageing Research at King's (ARK)

Cross faculty consortium addressing ageing and healthy longevity.

synthetic-biology
RNA Biology

RNA is at the forefront of biomedical research for its central role in how information is transferred from DNA to protein. This Research Interest Group is open to all interested parties from across the University.

Crick
The Francis Crick Institute

King’s is delighted to be a founding academic partner alongside UCL and Imperial College in the Francis Crick Institute, joining the multidisciplinary research expertise from all the Partners together to deliver world-leading biomedical research.

News

King's College Hospital Chief Officers Visit Maurice Wohl Clinical Neuroscience Institute

Professor Clive Kay and Dr Leonie Penna met with School of Neuroscience researchers to learn about clinical and academic partnerships.

KCHvisit2thumbnail

New Wellcome Discovery Award to study gene regulation in autism spectrum disorder and Alzheimer's disease.

Professor Jernej Ule, Dr Laura Andreae, and Professor Ben Blencowe have received £5,443,308 for the project “Context-dependent RNA regulation and its...

synapse-neuron.x9d419a4e

New Centre Director joins UK DRI at King's College London

King’s College London welcomes Professor Jernej Ule as the new Centre Director at UK Dementia Research Institute (UK DRI) at King's

Jernej Ule

Events

27JanMMG seminar photo 780x450

The interplay of RNA structure and protein disorder in protein-RNA condensates

Seminar with Professor Jernej Ule

Please note: this event has passed.

05DecJernej Ule inagural

Professor Jernej Ule - Inaugural Lecture

Join us in celebrating Professor Jernej Ule's inaugural lecture on 'Understanding protein-RNA condensates and their disruptions in ALS'

Please note: this event has passed.

Features

Introducing Professor Ben Blencowe

I talked to Professor Benjamin Blencowe, who recently joined the Centre for Developmental Neuroscience at the School of Neuroscience (IoPPN). I asked him...

neuroscience-hero-banner-image-Cropped-1952x600