Professor Marc-David Ruepp Priv-Doz, PhD
Professor of RNA Biology and Molecular Neurodegeneration
Research interests
- Neuroscience
Biography
Marc-David Ruepp is Professor in RNA Biology and Molecular Neurodegeneration at the Institute of Psychiatry, Psychology & Neuroscience at King's College London.
He is a RNA biochemist interested in gene expression in health and disease with a specific focus on dysfunctional RNA metabolism in neurodegeneration.
Marc-David's main research objective is to uncover the impact and contribution of altered RNA metabolism on selective neuronal death in amyotrophic lateral sclerosis and fronto-temporal dementia.
Outside of King's, Marc-David is also a fellow of the United Kingdom Dementia Research Institute and currently one of the Academic Mentors for the PhD students in the Department of Basic & Clinical Neuroscience.
Key Collaborators
- Professor Chris Shaw, King's College London
- Dr. Caroline Vance, King's College London
- Professor Frederic Allain, ETH Zuerich
- Dr. Sarah Mizielinska, King's College London
Key Publications
- Loughlin et al., 2019. The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity. Mol Cell.
- Reber et al., 2018. CRISPR-Trap: a clean approach for the generation of gene knockouts and gene replacements in human cells. Molecular Biology of the Cell.
- Jutzi et al., 2018. The emerging role of minor intron splicing in neurological disorders. Cell Stress.
- Reber et al., 2016. Minor intron splicing is regulated by FUS and affected by ALS‐associated FUS mutants. The EMBO Journal.
- Raczynska et al., 2015. FUS/TLS contributes to replication-dependent histone gene expression by interaction with U7 snRNPs and histone-specific transcription factors. Nucleic Acids Res.
Research
RNA Biology
RNA is at the forefront of biomedical research for its central role in how information is transferred from DNA to protein. This Research Interest Group is open to all interested parties from across the University.
multiscale RNA Networks and Pathways King’s Prize Doctoral Programme
RNA, RNA biology, PhD programme, King’s College London, gene expression, RNA structure and function, RNA networks, RNA medicine, mRNA vaccine, RNA therapeutic
News
New mechanism found for neuronal death in Alzheimer's and frontotemporal dementia
Markers of a new mechanism for cell death, called karyoptosis, have been found in brains of patients with Alzheimer’s disease and frontotemporal dementia...
Faulty cellular 'energy supply' in Amyotrophic Lateral Sclerosis
New study found two common types of gene mutation in ALS are linked to dysfunction in mitochondria.
Over £1.4 million awarded to King's researchers to accelerate MND treatment development
Three projects led by researchers at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) have received MND Translational Accelerator awards...
Breakthrough disease mechanism behind Amyotrophic Lateral Sclerosis (ALS) uncovered
Researchers at UK Dementia Research Institute at King’s College London and ETH Zürich found a new role for RNA in the development of a neurodegenerative...
Events
Professor Marc-David Ruepp - Inaugural Lecture
Join us in celebrating Professor Ruepp's inaugural lecture on 'From Mountains to Metropolis: A Serendipitous Journey from RNA Biology to ALS'
Please note: this event has passed.
Research
RNA Biology
RNA is at the forefront of biomedical research for its central role in how information is transferred from DNA to protein. This Research Interest Group is open to all interested parties from across the University.
multiscale RNA Networks and Pathways King’s Prize Doctoral Programme
RNA, RNA biology, PhD programme, King’s College London, gene expression, RNA structure and function, RNA networks, RNA medicine, mRNA vaccine, RNA therapeutic
News
New mechanism found for neuronal death in Alzheimer's and frontotemporal dementia
Markers of a new mechanism for cell death, called karyoptosis, have been found in brains of patients with Alzheimer’s disease and frontotemporal dementia...
Faulty cellular 'energy supply' in Amyotrophic Lateral Sclerosis
New study found two common types of gene mutation in ALS are linked to dysfunction in mitochondria.
Over £1.4 million awarded to King's researchers to accelerate MND treatment development
Three projects led by researchers at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) have received MND Translational Accelerator awards...
Breakthrough disease mechanism behind Amyotrophic Lateral Sclerosis (ALS) uncovered
Researchers at UK Dementia Research Institute at King’s College London and ETH Zürich found a new role for RNA in the development of a neurodegenerative...
Events
Professor Marc-David Ruepp - Inaugural Lecture
Join us in celebrating Professor Ruepp's inaugural lecture on 'From Mountains to Metropolis: A Serendipitous Journey from RNA Biology to ALS'
Please note: this event has passed.