Dr Claire Troakes PhD

My research focuses on the pathology of neurodegenerative disease, including dementia and motor neuron disease. Currently I am using human tissue sample to examine the relationship between head injury and subsequent neurodegeneration as a method to investigate mechanisms that may initiate neuronal damage. I am also the Coordinator of the London Neurodegenerative Diseases Brain Bank; one of the largest brain banks in the UK, specialising in central nervous system tissue collection from neurodegenerative, neurological and psychiatric disease. I manage all aspects of tissue donation, consent, collection, storage and distribution of samples to researchers.

Please see my Research Staff Profile for more detail

Find out more about my research:

• Brain Bank

Key publications:

• Kattah et al., 2019. Heterogeneous Nuclear Ribonucleoprotein E2 (hnRNP E2) Is a Component of TDP-43 Aggregates Specifically in the A and C Pathological Subtypes of Frontotemporal Lobar Degeneration. Front Neurosci.
• Troakes et al., 2017. Clusterin expression is upregulated following acute head injury and localizes to astrocytes in old head injury. Neuropathology.
• Troakes et al., 2013. Transportin 1 colocalization with Fused in Sarcoma (FUS) inclusions is not characteristic for amyotrophic lateral sclerosis-FUS confirming disrupted nuclear import of mutant FUS and distinguishing it from frontotemporal lobar degeneration with FUS inclusions. Neuropathol Appl Neurobiol.

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Key collaborators:

• Professor Safa Al-Sarraj, King's College Hospital
• Dr Andrew King, King's College Hospital
• Professor Dag Aarsland, King's College London