Professor Cynthia Andoniadou Academics Supervisors Dean for Research Professor of Stem Cell Biology. Research subject areas Cell Biology Contact details 020 7188 7389 cynthia.andoniadou@kcl.ac.uk
EndoCompass project: research roadmap for reproductive and developmental endocrinology SOX2+ sustentacular cells are stem cells of the postnatal adrenal medulla Using parenclitic networks on phaeochromocytoma and paraganglioma tumours provides novel insights on global DNA methylation A splice site variant in MADD affects hormone expression in pancreatic β cells and pituitary gonadotropes Cellular interactions in the pituitary stem cell niche An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study Steroidogenic factor 1 regulates transcription of the inhibin B co-receptor in pituitary gonadotrope cells Adrenal Gland Function and Dysfunction During COVID-19 Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms Sexual dimorphism in COVID-19: potential clinical and public health implications TGFBR3L is an inhibin B co-receptor that regulates female fertility Loss of sdhb promotes dysregulated iron homeostasis, oxidative stress, and sensitivity to ascorbate Dynamic Expression of Imprinted Genes in the Developing and Postnatal Pituitary Gland The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells Insulin and obesity transform hypothalamic-pituitary-adrenal axis stemness and function in a hyperactive state Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development RNA in situ hybridization for human papillomavirus testing in oropharyngeal squamous cell carcinoma on a routine clinical diagnostic platform Biological Behaviour of Craniopharyngiomas Cancer Stem Cells in Pheochromocytoma and Paraganglioma Novel medications inducing adrenal insufficiency Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease? Non-secreting pituitary tumours characterised by enhanced expression of YAP/TAZ Prognostic utility of HPV specific testing in addition to p16 immunohistochemistry in oropharyngeal squamous cell carcinoma Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target Basic Research Advances on Pituitary Stem Cell Function and Regulation Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma Genetically modified mouse models of adamantinomatous craniopharyngioma Preface Basic research and clinical aspects of adamantinomatous craniopharyngioma Pituitary Stem Cells During Normal Physiology and Disease Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation? The effects of stress on brain and adrenal stem cells Expression Analysis of the Hippo Cascade Indicates a Role in Pituitary Stem Cell Development STAT3-Ser/Hes3 Signaling: A New Molecular Component of the Neuroendocrine System? Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans Activated WNT signaling in postnatal SOX2-positive dental stem cells can drive odontoma formation Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling The role of the sonic hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism CHD7 maintains neural stem cell quiescence and prevents premature stem cell depletion in the adult hippocampus View all publications
22 July 2024 Academic Promotions 2024 Many congratulations to the following members of the Faculty of Dentistry, Oral & Craniofacial…