Professor Deepak Srivastava PhD

Biography

My lab group investigates synaptic biology in in health and disease, focusing on the  cellular and physiological aspect of disease with a translational focus. We study the molecular mechanisms underlying the regulation of glutamatergic synapses and how genetic risk factors for disease, impact synaptic biology. To achieve this, we utilize cutting-edge technologies such as patient derived induced pluripotent stem cells (iPSCs) and advanced cellular imaging approaches. This allows us to investigate the dynamic and nanoscopic organisation of synaptic proteins, as well as structural and functional remodelling of synapses, and we work closely with basic and clinical colleagues as well as pharmaceutical companies to address these questions. I also lead the Wohl Cellular Imaging Centre (WCIC), an advanced light microscopy facility, specialising in imaging needs for neuroscience research.

Please see my Research Staff Profile for more detail.

Find out more about my research:

• KCL Wohl Imaging Centre

Key Publications:

• Bhat et al., 2022. Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells. Brain, Behavior, and Immunity. 
• Gatford et al., 2022. Neuroligin-3 and neuroligin-4X form nanoscopic clusters and regulate growth cone organization and size. Human Molecular Genetics.
• Warre-Cornish et al., 2020. Interferon-γ signaling in human iPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes. Science Advances.
• Adhya et al., 2021. Atypical neurogenesis in induced pluripotent stem cells from autistic individuals. Biological Psychiatry.
• Deans et al., 2017. Psychosis risk candidate ZNF804A localizes to synapses and regulates neurite formation and dendritic spine structure. Biological Psychiatry.

View all publications

Key Collaborators:

• Dr Anthony Vernon, King's College London
• Professor Oliver Howes, King's College London
• Dr Kristen Brennand, Icahn School of Medicine
• Professor Jack Price, National Institute for Biological Standards & King's College London