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Schizophrenia

Schizophrenia is associated with severe behavioural and cognitive deficits, and extensive changes in brain structure and function. We aim to provide new insights into the neurobiology of schizophrenia by combining imaging studies in humans with a range of other models.

Two of the most consistent neuropathological findings are alterations in the prefrontal cortex, hippocampus and adjacent medial temporal lobe structures, and elevated presynaptic dopamine function in the striatum. The aim of this programme is to provide new insights into the neurobiology of schizophrenia by combining imaging studies in humans with mechanistic studies in mouse models.

Our key questions:

  • How do changes in specific brain regions (prefrontal cortex, hippocampus and medial temporal lobe structures) underlie schizophrenia?
  • How do changes in brain structure and function trigger schizophrenia?
  • Which models are most effective for studying brain alterations seen in schizophrenia? How can we improve them?
  • How do we build a coherent picture of how functional circuits in the brain come together during development to control behaviour?

Schizophrenia is a key research theme of the MRC Centre for Neurodevelopmental Disorders, which brings together world-leading researchers across King's College London.

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Our research

Our research

Leading the world in understanding brain function and finding new treatments for patients

What is neuroscience?

What is neuroscience?

Neuroscience is the study of the nervous system, from structure to function, in health and disease

Discover more about Neuroscience at King’s

Centres

Centres

Specialist neuroscience centres, world-leading in understanding the brain at all stages of life

Resources

Resources

World-class neuroscience facilities, including MRI, neuroimaging equipment, and King's Brain Bank

PhD

PhD

Join a lively community of PhD students, learning from world-leading neuroscience researchers

 

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