Mitul joined King’s College London as a post-doctoral researcher in Neuroimaging in 2003 with the aim of setting up a research group focussed on pharmacological neuroimaging using MRI methodology. He worked with positron emission tomography at Imperial College for a number of years as an MRC Training Fellow before moving to King’s. A Wellcome Trust Value in People Award enabled the transition. His work was recognised by the British Association for Psychopharmacology Young Investigator Award. At King’s my group brought quantitative methods to identify drug mechanisms and classify different compounds and used classic tracking methods (phMRI) to develop assays of drug modulation. These methods are utilised to understand existing compounds as well as assay novel compounds and we have tested various mechanisms, including in collaboration with the pharmaceutical industry.
Currently, Mitul is Head of the Neuropharmacology Group and Section in the Department of Neuroimaging, Deputy Lead for the Neuroimaging Theme of the NIHR-Maudsley Biomedical Research Centre for Mental Health and Director of the IoPPN Centre for Innovative Therapeutics. Outside of King’s he has served on the Council for the British Association for Psychopharmacology as a member (2011-2014) and meetings secretary (2015-2020).
Mitul has a keen interest in brain modulation methods, primarily with pharmacological agents with a goal to enhance research into novel treatment in psychiatric and neurological syndromes. He works on all stages of the research process in humans, including practical aspects of study design and implementation, novel task development, image acquisition and analytical approaches. He has examined drugs that target dopamine, noradrenaline, serotonin, glutamate, acetycholine and histamine receptors as well as intracellular modulators. Our work is relevant for multiple syndromes including ADHD, schizophrenia, depression and Parkinson’s disease.
- Research Methods
- Pharmacological Imaging
Expertise and public engagement
Mitul has been involved with the British Association for Psychopharmacology in organising the annual Summer Meeting, including a lecture for the public. He also co-leads a biennial residential course in non-clinical psychopharmacology.
He have acted as a consultant to various companies and sat on advisory boards.
In terms of public engagement, he and group members regularly work with the scientific or general media on articles, interviews, programming. They had a live experiment to showcase psychopharmacology research at the Science Gallery.
Barnby, J., Bell, V., Mehta, M. & Moutoussis, M., Sep 2020, (Accepted/In press) In : PLoS Computational Biology. Research output: Contribution to journal - Article
Gilleen, J., Nottage, J., Yakub, F., Kerins, S., Valdearenas, L., Uz, T., Lahu, G., Tsai, M., Ogrinc, F., Williams, S. C., Ffytche, D., Mehta, M. A. & Shergill, S. S., 1 Jan 2020, (Accepted/In press) In : Journal of Psychopharmacology. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1177/0269881120946300
Golm, D., Sarkar, S., MacKes, N. K., Fairchild, G., Mehta, M. A., Rutter, M. & Sonuga-Barke, E. J., 1 Jan 2020, (Accepted/In press) In : Psychological Medicine. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1017/S0033291720001294
McCutcheon, R. A., Jauhar, S., Pepper, F., Nour, M. M., Rogdaki, M., Veronese, M., Turkheimer, F. E., Egerton, A., McGuire, P., Mehta, M. M. & Howes, O. D., 23 Apr 2020, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.bpsc.2020.04.004
Barnby, J., Deeley, Q., Bell, V. & Mehta, M., 11 Jun 2020, (Accepted/In press) In : Translational psychiatry. 32 p. Research output: Contribution to journal - Article
Dipasquale, O., Martins, D., Sethi, A., Veronese, M., Hesse, S., Rullmann, M., Sabri, O., Turkheimer, F., Harrison, N. A., Mehta, M. A. & Cercignani, M., 1 Aug 2020, In : Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 45, 9, p. 1482-1489 8 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41386-020-0724-x
Bland, A. R., Schei, T., Roiser, J. P., Mehta, M. A., Zahn, R., Seara-Cardoso, A., Viding, E., Sahakian, B. J., Robbins, T. W. & Elliott, R., 1 Oct 2020, In : Personality and Individual Differences. 164, 110125. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.paid.2020.110125
Barnby, J. M., Deeley, Q., Robinson, O., Raihani, N., Bell, V. & Mehta, M. A., 1 Mar 2020, In : Royal Society open science. 7, 3, rsos191525. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1098/rsos.191525
Mehta, M. A. & Tricklebank, M. D., 1 Jan 2019, The Serotonin System: History, Neuropharmacology, and Pathology. Elsevier, p. 193-202 10 p. Research output: Chapter in Book/Report/Conference proceeding - Chapter. DOIs: https://doi.org/10.1016/B978-0-12-813323-1.00011-6
the ENIGMA-ADHD working group, the ENIGMA-ASD working group, the ENIGMA-OCD working group, Arango, C., Chantiluke, K. C., Christakou, A., Cubillo, A. I., Daly, E., Freitag, C. M., Kelly, C., Kuntsi, J., Marsh, R., Mataix-Cols, D., Mehta, M. A., Murphy, C. M., Murphy, D. G. M., Paloyelis, Y., Rubia, K., Shaw, P. & Wallace, G. L., 22 Mar 2020, (Accepted/In press) In : American Journal of Psychiatry. Research output: Contribution to journal - Article