Dr Prischi is a molecular biochemist whose work spans in vitro and in silico approaches to gain a greater understanding of protein regulation and stress responses. The overall aim of his research is to understand how the molecular machines that compose signalling pathways work together to transfer information in normal and stressed conditions. Unravelling protein regulation mechanisms is critical for advancing our understanding of disease progression and for the development of novel personalised treatments.

His projects focus on (i) the functional and structural characterisation of the p70 and p90 Ribosomal S6 Kinase families and their key substrates, (ii) the development and use of high-throughput bioinformatics approaches coupled with structural biology methods to increase our understanding of protein dynamics and ligand binding. Dr Prischi’s lab use a cutting-edge multi-disciplinary approach that combines biophysical, enzymatic, cellular and structural studies. Using X-ray crystallography, Nuclear Magnetic Resonance (NMR), Electron Microscopy (cryo-EM) coupled with Molecular Dynamics simulations (MD) they visualise macromolecules at atomic and near atomic resolution. At this scale they aim to dissect cellular processes at a molecular level and describe the details at the base of disease development, thereby providing a solid base for medical advance.