Skip to main content

King’s People

Professor Francesco Dazzi

Academics
Supervisors

Vice Dean (International) and Head of Regenerative Medicine

Contact details

Biography

Professor Francesco Dazzi has been working on the biology and clinical applications of cellular therapies in haemopoietic stem cell transplantation for the last 20 years. He obtained an MD and a PhD at Padua University Medical School (Italy) and subsequently trained as a Haematologist at Verona University and at the Royal Postgraduate Medical School (London, UK). He was appointed Senior Lecturer and then Professor in Stem Cell Biology at Imperial College in 2005. In 2014 he moved to King’s College London where he is Professor of Regenerative & Haematological Medicine and leads Cellular Therapies for Kings’ Health Partners.

Francesco pioneered a large and highly successful cellular immunotherapy programme for leukaemia and characterised the immunosuppressive effects of mesenchymal stromal cells (MSC). His team successfully tested MSC in pre-clinical models and the work has formed the basis of UK wide clinical studies.

Professor Dazzi was appointed to the role of Vice-Dean (International) for the Faculty of Life Sciences & Medicine in 2019.

Latest publications

Pluripotent stem cell-derived hepatocytes inhibit T cell proliferation in vitro through tryptophan starvation
Romano, M., Elgueta, R., McCluskey, D., Ortega-Prieto, A. M., Stolarczyk, E., Dazzi, F., Lucendo-Villarin, B., Meseguer-Ripolles, J., Williams, J., Fanelli, G., Hay, D. C., Watt, F. M. & Lombardi, G., 1 Jan 2022, In: Cells. 11, 1, 24. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3390/cells11010024
Macrophages orchestrate the expansion of a proangiogenic perivascular niche during cancer progression
Opzoomer, J. W., Anstee, J. E., Dean, I., Hill, E. J., Bouybayoune, I., Caron, J., Muliaditan, T., Gordon, P., Sosnowska, D., Nuamah, R., Pinder, S. E., Ng, T., Dazzi, F., Kordasti, S., Withers, D. R., Lawrence, T. & Arnold, J. N., 5 Nov 2021, In: Science Advances. 7, 45, p. eabg9518 eabg9518. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1126/sciadv.abg9518
Macrophages orchestrate the expansion of a pro-angiogenic perivascular niche during cancer progression
Opzoomer, J. W., Anstee, J. E., Dean, I., Hill, E. J., Bouybayoune, I., Caron, J., Muliaditan, T., Gordon, P., Sosnowska, D., Nuamah, R., Pinder, S. E., Ng, T., Dazzi, F., Kordasti, S., Withers, D. R., Lawrence, T. & Arnold, J. N., 3 Nov 2021, In: Science Advances. Research output: Contribution to journal › Article › peer-review
Apoptosis in the Pancreatic Cancer Tumor Microenvironment-The Double-Edged Sword of Cancer-Associated Fibroblasts
Pfeifer, E., Burchell, J. M., Dazzi, F., Sarker, D. & Beatson, R., 1 Jul 2021, In: Cells. 10, 7, 1653. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.3390/cells10071653
Apoptosis in the Pancreatic Cancer TumorMicroenvironment— The Double-Edged Sword of Cancer-Associated Fibroblasts
Pfeifer, E., Burchell, J., Dazzi, F., Sarker, D. & Beatson, R., 1 Jul 2021, In: Cells. 10, 1653, 18 p. Research output: Contribution to journal › Review article › peer-review
Lyve-1 expressing macrophages direct the expansion of pericytes within the perivascular niche to support angiogenesis in cancer.
Opzoomer, J. W., Anstee, J. E., Dean, I., Hill, E. J., Bouybayoune, I., Caron, J., Muliaditan, T., Gordon, P., Nuamah, R., Pinder, S. E., Ng, T., Dazzi, F., Kordasti, S., Withers, D. R., Lawrence, T. & Arnold, J. N., Jul 2021, In: Cancer Research. 81, 13 Research output: Contribution to journal › Meeting Abstract › peer-review
Acute myeloid leukemia shapes the bone marrow stromal niche in vivo
Pievani, A., Donsante, S., Tomasoni, C., Corsi, A., Dazzi, F., Biondi, A., Riminucci, M. & Serafini, M., Mar 2021, In: Haematologica. 106, 3, p. 865-870 6 p. Research output: Contribution to journal › Letter › peer-review. DOIs: https://doi.org/10.3324/haematol.2020.247205
Immunomodulatory Properties of Mesenchymal Stromal Cells: An Update
Müller, L., Tunger, A., Wobus, M., von Bonin, M., Towers, R., Bornhäuser, M., Dazzi, F., Wehner, R. & Schmitz, M., 9 Feb 2021, In: Frontiers in Cell and Developmental Biology. 9, 637725. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.3389/fcell.2021.637725
The emergence of regenerative medicine in organ transplantation: 1st European Cell Therapy and Organ Regeneration Section meeting
Hoogduijn, M. J., Montserrat, N., van der Laan, L. J. W., Dazzi, F., Perico, N., Kastrup, J., Gilbo, N., Ploeg, R. J., Roobrouck, V., Casiraghi, F., Johnson, C. L., Franquesa, M., Dahlke, M. H., Massey, E., Hosgood, S. & Reinders, M. E. J., 1 Aug 2020, In: Transplant International. 33, 8, p. 833-840 8 p. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1111/tri.13608
Mesenchymal Stromal Cells for Graft Versus Host Disease: Mechanism-Based Biomarkers
Cheung, T. S., Bertolino, G. M., Giacomini, C., Bornhäuser, M., Dazzi, F. & Galleu, A., 25 Jun 2020, In: Frontiers in Immunology. 11, 1338. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2020.01338

View all publications