Dr Gavin Bewick Academics Supervisors Reader in Endocrinology and Metabolism Acting Head, Department of Diabetes. Research subject areas Diabetes Contact details gavin.bewick@kcl.ac.uk @gavbew
Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy Pavlidis, P., Tsakmaki, A., Pantazi, E., Li, K., Cozzetto, D., Digby-Bell, J., Yang, F., Lo, J. W., Alberts, E., Sa, A. C. C., Niazi, U., Friedman, J., Long, A. K., Ding, Y., Carey, C. D., Lamb, C., Saqi, M., Madgwick, M., Gul, L., Treveil, A., & 5 othersKorcsmaros, T., Macdonald, T. T., Lord, G. M., Bewick, G. & Powell, N., Dec 2022, In: Nature Communications. 13, 1, p. 5820 5820. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41467-022-33331-8 Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease Pavlidis, P., Tsakmaki, A., Treveil, A., Li, K., Cozzetto, D., Yang, F., Niazi, U., Hayee, B. H., Saqi, M., Friedman, J., Korcsmaros, T., Bewick, G. & Powell, N., 27 Sep 2022, In: Cell Reports. 40, 13, p. 111439 111439. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.celrep.2022.111439 Sulfated Progesterone Metabolites That Enhance Insulin Secretion Via Trpm3 are Reduced in Serum From Women with Gestational Diabetes Mellitus Fan, H. M., Mitchell, A. L., Bellafante, E., McIlvride, S., Primicheru, L. I., Giorgi, M., Eberini, I., Syngelaki, A., Lövgren-Sandblom, A., Jones, P., McCance, D., Sukumar, N., Periyathambi, N., Weldeselassie, Y., Hunt, K. F., Nicolaides, K. H., Andersson, D., Bevan, S., Seed, P. T., Bewick, G. A., & 5 othersBowe, J. E., Fraternali, F., Saravanan, P., Marschall, H. & Williamson, C., 1 Apr 2022, In: Diabetes. 71, 4, p. 837-852 16 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.2337/db21-0702 COVID-19 and metabolic disease: mechanisms and clinical management Steenblock, C., Schwarz, P. E. H., Ludwig, B., Linkermann, A., Zimmet, P., Kulebyakin, K., Tkachuk, V. A., Markov, A. G., Lehnert, H., de Angelis, M. H., Rietzsch, H., Rodionov, R. N., Khunti, K., Hopkins, D., Birkenfeld, A. L., Boehm, B., Holt, R. I. G., Skyler, J. S., DeVries, J. H., Renard, E., & 16 othersEckel, R. H., Alberti, K. G. M. M., Geloneze, B., Chan, J. C., Mbanya, J. C., Onyegbutulem, H. C., Ramachandran, A., Basit, A., Hassanein, M., Bewick, G., Spinas, G. A., Beuschlein, F., Landgraf, R., Rubino, F., Mingrone, G. & Bornstein, S. R., Nov 2021, In: The Lancet Diabetes and Endocrinology. 9, 11, p. 786-798 13 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/S2213-8587(21)00244-8 The way to the heart of diabetes is through your gut Bewick, G. & Jacobs, M., 12 Apr 2021, In: Biochemist. 43, 2, p. 10-14 5 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1042/bio_2021_111 Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism West, J. A., Tsakmaki, A., Ghosh, S. S., Parkes, D. G., Grønlund, R. V., Pedersen, P. J., Maggs, D., Rajagopalan, H. & Bewick, G. A., 1 Apr 2021, In: PLoS ONE. 16, 3 March 2021, p. e0249239 e0249239. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1371/journal.pone.0249239 Diabetes through a 3D lens: organoid models Tsakmaki, A., Fonseca Pedro, P. & Bewick, G. A., 1 Jun 2020, In: Diabetologia. 63, 6, p. 1093-1102 10 p. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1007/s00125-020-05126-3 ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human organoids Tsakmaki, A., Fonseca Pedro, P. A., Pavlidis, P., Hayee, B. H. & Bewick, G., 30 Apr 2020, In: Molecular Metabolism. 34, p. 157-173 17 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.molmet.2020.01.012 Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy Ovadia, C., Perdones-Montero, A., Fan, H. M., Mullish, B. H., McDonald, J. A. K., Papacleovoulou, G., Wahlström, A., Ståhlman, M., Tsakmaki, A., Clarke, L. C. D., Sklavounos, A., Dixon, P. H., Bewick, G. A., Walters, J. R. F., Marschall, H-U., Marchesi, J. R. & Williamson, C., 3 Mar 2020, In: Scientific Reports. 10, 1, 10 p., 3895. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41598-020-60821-w Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells Powell, N., Pantazi, E., Pavlidis, P., Tsakmaki, A., Li, K., Yang, F., Parker, A., Pin, C., Cozzetto, D., Minns, D., Stolarczyk, E., Saveljeva, S., Mohamed, R., Lavender, P., Afzali, B., Digby-Bell, J., Tjir-Li, T., Kaser, A., Friedman, J., MacDonald, T. T., & 2 othersBewick, G. A. & Lord, G. M., 7 Feb 2020, In: Gut. 69, 3, p. 578-590 13 p. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1136/gutjnl-2019-318483 View all publications