Professor Gavin Bewick Academics Supervisors Professor in Endocrinology and Metabolism Theme lead for Diabetes and Obesity. Co-Director for Diabetes Endocrinology and Obesity Clinical Academic Partnership – Kings Health Partners. Research subject areas Diabetes Contact details gavin.bewick@kcl.ac.uk @gavbew
Extracellular Ca 2+ -Sensing Receptor (CaSR) Regulates Hypothalamic Function to Control Energy and Skeletal Metabolism in Mice. Measurement of Real-Time Serotonin Dynamics from Human-Derived Gut Organoids Progesterone sulfates are enterohepatically recycled and stimulate G protein-coupled bile acid receptor 1-mediated gut hormone release Dietary Protein Defends Lean Mass and Maintains the Metabolic Benefits of Glucagon Receptor Agonism in Mice Fasting pancreatic polypeptide predicts incident microvascular and macrovascular complications of type 2 diabetes: An observational study Reformed islets: a long-term primary cell platform for exploring mouse and human islet biology Society for Endocrinology guidelines for the diagnosis and management of post-bariatric hypoglycaemia. The selective serotonin reuptake inhibitors, sertraline and paroxetine, improve islet beta-cell mass and function in vitro Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease Editorial: Hungry for more: What's new in appetite regulation Endocrinology: Hormones are the Puppeteers of Physiology Endocrinology: Hormones are the Puppeteers of Physiology Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy Sulfated Progesterone Metabolites That Enhance Insulin Secretion Via Trpm3 are Reduced in Serum From Women with Gestational Diabetes Mellitus Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism COVID-19 and metabolic disease: mechanisms and clinical management The way to the heart of diabetes is through your gut Diabetes through a 3D lens: organoid models Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human organoids The Glucose Tolerance Test in Mice Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy Enteroendocrine progenitor cell enriched miR-7 regulates intestinal epithelial proliferation in an Xiap-dependent manner Histologic assessment of the intestinal wall following duodenal mucosal resurfacing (DMR): a new procedure for the treatment of insulin-resistant metabolic disease Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish 3D intestinal organoids in metabolic research: virtual reality in a dish Editorial overview: Endocrine and metabolic diseases: Busting BMI: new strategies for the treatment of obesity and metabolic disease Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety Islet neuropeptide Y receptors are functionally conserved and novel targets for the preservation of beta-cell mass The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro. Glucokinase activity in the arcuate nucleus regulates glucose intake GPRC6a is not required for the effects of a high-protein diet on body weight in mice L-cysteine suppresses ghrelin and reduces appetite in rodents and humans Peptide YY: More than just an appetite regulator The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem Bowels control brain: gut hormones and obesity Selective Ablation of Peptide YY Cells in Adult Mice Reveals Their Role in Beta Cell Survival The role of the gut/brain axis in modulating food intake Alarin stimulates food intake and gonadotrophin release in male rats Cerebellin1 is a novel orexigenic peptide Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake The Hyperphagic Effect of Ghrelin Is Inhibited in Mice by a Diet High in Fat Hypothalamic Injection of Oxyntomodulin Suppresses Circulating Ghrelin-Like Immunoreactivity Mice With Hyperghrelinemia Are Hyperphagic and Glucose Intolerant and Have Reduced Leptin Sensitivity The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats View all publications