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Professor Mann obtained his BSc in Zoology (1973) from George Washington University, Washington D.C. USA and MSc (1974) and PhD in Physiology (1978) from University College London. He was subsequently appointed to a 4-year postdoctoral Research Fellowship at Queen Elizabeth College London and then to a Lectureship in Physiology (1981), Readership in Physiology (1992) and as Professor of Vascular Physiology (1997-) at King’s.

He is currently President-Elect of the Society of Free Radical Research-International (SFRRI), and previously served as General Secretary of SFRRI, Chairman of The Physiological Society, President of the British Microcirculation Society, President of the European Microcirculation Society, President of the Society for Free Radical Research-Europe and President of the European Pancreatic Society. He was elected as a Fellow of The Physiological Society in 2018. Professor Mann serves as Reviews and Special Issues Editor for Free Radical Biology & Medicine and Chair of the Ethics Committee. He has served on Editorial Boards of The Journal of Physiology, Microcirculation and as Editorial Advisor for the Biochemical Journal. He is a member of the Translational Sciences Panel of Heart Research UK, Board of External Referees for the Biotechnology & Biological Sciences Research Council and College of Experts for the Medical Research Council - Physiological Systems & Clinical Sciences. He has previously served as Chair of the Translational Sciences Panel for Heart Research UK, Medical Panel of the Henry Smith Charity and on grant panels of the British Heart Foundation, Guy's & St. Thomas’ Hospital Charitable Foundation and Royal Society International Networks Panel. He is currently International Lead for the School of Cardiovascular Medicine & Sciences at King’s. Professor Mann has published >160 research papers and coordinated >38 research symposia at international conferences.

Professor Mann’s Vascular Biology research group is investigating signalling cascades involved the transcriptional activation of Nrf2-targeted antioxidant defence genes in endothelial and smooth muscle cells in oxidative stress and vascular dysfunction in diseases such as ischemic stroke, atherosclerosis and gestational diabetes.  and have demonstrated the health benefits of dietary sulforaphane as an activator of Nrf2-targeted antioxidant enzymes.