The London Metallomics Facility (LMF) is a King’s College London core research facility, providing state-of-the-art analytical tools to understand the critical roles of metals in biological processes. Our vision is to be a centralised hub for comprehensive multi-institutional integration of metallomic analytics, establishing direct interactions between leading research groups, commercial partners, and industry, whilst driving educational outreach and public engagement strategies.
The LMF is part of King's network of Core Facilities. We provide expert advice and bespoke service for analysis of metals, particularly in complex biological samples including experimental design and conceptualisation, sample preparation, measurement execution, data analysis and interpretation. We facilitate both bulk quantification through ICP-MS, and an imaging approach, through LA-ICP-MS, generating versatility for users. The LMF has developed unique data processing pipelines which output publication quality data and statistics.
We offer technical consultation and ongoing support to both the research and commercial communities, ensuring users achieve high-quality data outputs.
Facility staff
Manager - London Metallomics Facility
Deputy Manager, London Metallomics Facility
Mass Spectrometry Analyst, London Metallomics Facility
Affiliated academics
Lecturer in Imaging Chemistry
Professor of Metallomics
Professor of Imaging Chemistry and Head of Department of Imaging Chemistry and Biology
Business Development Manager (Core Facilities)
Professor of Vascular Physiology
Emeritus Professor
Professor of Nutritional Sciences
Reader in Biomedical Imaging and Spectroscopy
Professor of Toxicogenomics
Head of Centre for Oral, Clinical & Translational Sciences
Reader
Lecturer in Immunology and Drug Discovery
Reader in Cardiac Molecular Imaging
Professor of Molecular Ecotoxicology
We have a wide range of equipment available for use, including:
Related equipment
Vitesse ICP-TOF-MS
The Vitesse is a high-speed, time-of-flight ICP-MS, ideal for metallomic imaging and single-cell analysis, detecting most elements.
PerkinElmer NexION 5000 ICP-MS
NexION 5000: Multi-quadrupole ICP-MS for bulk solution analysis with high sensitivity, down to parts-per-quadrillion.
Thermofisher iCAP TQ ICP-MS
iCAP TQ: Triple quadrupole ICP-MS, ideal for imaging with laser ablation. Excels in sensitivity and interference control.
Teledyne Iridia Laser Ablation System
Iridia: 193 nm laser ablation system, 1-50 micron spot size, for soft to hard substrates. High-speed, sub-cellular imaging with ICP-MS.
Autosamplers
Autosamplers for ICP-MS: automate 240-sample batches for high-throughput analysis.
Bruker S2 PICOFOX TXRF
S2 PICOFOX TXRF: Portable, low pg/ppb sensitivity for small/matrix-rich liquid samples, versatile for various types.
Milestone Microwave Digestor
UltraWAVE: High-pressure microwave digestor for complex samples, no assembly or cleaning needed between uses.
Clean Room
The clean room within the facility includes a Metal free class 2 Biosafety cabinet and metal free laminar flow fume hood.
The London Metallomics Facility is a central hub for advanced metallomic analytics, promoting interaction between diverse areas of academic research, industry, and equipment manufacturers. It also plays a key role in education and training within this emerging field, providing necessary expertise and support to researchers.
King's Together Strategic Award - Metallomics Symposium 2021
The roles of metals in human health
Researchers at the LMF, backed by Wellcome Trust funding, are working on the cutting edge of inorganic biochemistry, with implications for how we understand, diagnose and treat human diseases like diabetes, cancer and Alzheimer’s disease.
Monday Science Podcast Interviews
Listen to Monday Science podcast interviews- featuring Dr. Theodora Stewart.
Awards
-
London Metallomics Facility - Wellcome Trust Multi-user Equipment Grant
-
Metallomic profiling and redox signalling in human coronary artery endothelial and smooth muscle cells in physiological normoxia and ischaemia/reperfusion injury - Heart Research UK
-
Multidimensional Metallomic Imaging for Environmental Hazard Analysis - Natural Environment Research Council
-
PET metallomics in cancer: predicting response to platinum drugs - Medical Research Council
-
Metallomic Profiling and Imaging for Understanding Skin and Scalp Biology - BBSRC LIDo
-
Metal Fingerprints in Normal Cell States and Disease - King's Together Strategic Award
- Integrated multi-modal tissue state mapping of TNBC progression-
2023 Publications
Smith M.J, Yang F, Griffiths A, Morrell A, Chapple S.J, Siow R.C.M, Stewart T, Maret, W, and Mann, G.E (2023) Redox and metal profiles in human coronary endothelial and smooth muscle cells under hyperoxia, physiological normoxia and hypoxia: effects of NRF2 signaling on intracellular zinc, j.redox.2023.102712.
Han S, Wang J.T-W, Yavuz E, Zam A, Rouatbi N, Utami R.N, Liam-Or, R, Griffiths A., Dickson W, Sosabowski J, Al-Jamal K.T, (2023). Spatiotemporal tracking of gold nanorods after intranasal administration for brain targeting, j.jconrel.2023.04.022.
Weston A, Vladescu S.C, Reddyhoff T, Griffiths A., Crouzier T., Fielden M, Garnett J.A, Carpenter G.H, (2023). The Influence of Ions on the Lubricative Abilities of Mucin and the Role of Sialic Acids, j.colsurfb.2023.113327.
Firth G, Georgiadou E, Griffiths A, Amrahli M, Kim J, Yu Z, Hu M, Stewart T, Leclerc I, Okamoto H, Gomez D, Blower P.J, Rutter G.A, (2023). Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice, fendo.2023.1171933.
Yang F, Smith M.J, Griffiths A, Morrell A, Chapple S.J, Siow R.C.M, Stewart T., Maret W, Mann G.E, (2023). Vascular protection afforded by zinc supplementation in human coronary artery smooth muscle cells mediated by NRF2 signalling under hypoxia/reoxygenation, j.redox.2023.102777.
Morrell A.P, Martin R.M, Roberts H.M, Castillo-Michel H., Mosselmans J.F.W, Geraki K, Warfield A.T, Lingor P, Qayyum W, Graf D, Febbraio M, Addison O, (2023). Addressing uncertainties in correlative imaging of exogenous particles with the tissue microanatomy with synchronous imaging strategies, mfad030.
2022 Publications
Wan Y, Stewart T, Amrahli M, Evans J, Sharp P, Govindan V, Hawkesford MJ, Shewry PR, (2022) Localisation of iron and zinc in grain of biofortified wheat, J. Cereal Sci. in press.
2021 Publications
Goncalves J., Moog S, Morin A, Gentric G, Müller S, Morrell AP, Kluckova K, Stewart TJ, Andoniadou CL, Lussey-Lepoutre C, Bénit P, Thakker A, Vettore L, Roberts J, Rodriguez R, Mechta-Grigoriou F, Gimenez-Roqueplo AP, Letouzé E, Tennant DA, Favier J (2021) Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate, Cancer Res. 81:3480–3494.
Unosson J, Kabéle M, Boman C, Nyström R, Sadiktsis I, Westerholm R, Mudway IS, Purdie E, Raftis J, Miller MR, Mills NL, Newby DE, Blomberg A, Sandström T, Bosson JA (2021) Acute cardiovascular effects of controlled exposure to dilute Petrodiesel and biodiesel exhaust in healthy volunteers: a crossover study. Part Fibre Toxicol. 18:22.
Osytek KM, Blower PJ, Costa IM, Smith GE, Abbate V, Terry SYA (2021) In vitro proof of concept studies of radiotoxicity from Auger electron-emitter thallium-201 EJNMMI Res 11: 63.
Alaohali A, Brauer DS, Gentleman E, Sharpe PT (2021) A modified glass ionomer cement to mediate dentine repair Dental Materials 37:1307-1315.
Frangos T, Maret W (2021) Zinc and Cadmium in the Aetiology and Pathogenesis of Osteoarthritis and Rheumatoid Arthritis. Nutrients. 13:53.
2020 Publications
Ashraf A, Jeandriens J, Parkes HG, So PW (2020) Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer's disease: Evidence of ferroptosis. Redox Biology 32:101494.
Kutscher D, Asogan D, Mudway I, Brekke P, Beales C, Wang X, Perkins M, Maret W, Stewart T (2020) Imaging of Trace Elements Using Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry: Emerging New Applications Spectroscopy 35:16–26.
Muraina IA, Bury NR, Scott A, Graham A, Hogstrand C (2020) The zebrafish Znt1asa17 mutant reveals roles of zinc transporter-1a in embryonic development. J. Trace Elem. Med. Biol. 60:126496.
Selley L, Schuster L, Marbach H, Forsthuber T, Forbes B, Gant TW, Sandstrom T, Camina N, Athersuch TJ, Mudway I, Kumar A (2020) Brake dust exposure exacerbates inflammation and transiently compromises phagocytosis in macrophages. Metallomics. 12:371-386.
2019 Publications
Fitzgerald JA, Urbina MG, Rogers NJ, Bury NR, Katsiadaki I, Wilson RW, Santos EM (2019) Sublethal exposure to copper supresses the ability to acclimate to hypoxia in a model fish species. Aquatic Toxicology 217:105325.
Stewart TJ (2019) Across the spectrum: integrating multidimensional metal analytics for in situ metallomic imaging. Metallomics. 11:29–49.
Zhang K, Alaohali A, Sawangboon N, Sharpe PT, Brauer DS, Gentleman E (2019) A comparison of lithium-substituted phosphate and borate bioactive glasses for mineralised tissue repair Dental Materials 35: 919-927.
Maret W (2019) The redox biology of redox-inert zinc ions. Free Radic Biol Med. 134:311-326.
Koppenol WH, Hider R (2019) Iron and redox cycling. Do's and don'ts. Free Radic Biol Med. 133:3-10.
Kose T, Vera-Aviles M, Sharp PA, Latunde-Dada GO (2019) Curcumin and (−)- Epigallocatechin-3-Gallate Protect Murine MIN6 Pancreatic Beta-Cells against Iron Toxicity and Erastin-Induced Ferroptosis Pharmaceuticals. 12: 26.
Ashraf A, Stosnach H, Parkes HG, Hye A, Powell J, So PW (2019) Pattern of Altered Plasma Elemental Phosphorus, Calcium, Zinc, and Iron in Alzheimer’s Disease. Scientific Reports 9:3147.
Cusnir R, Cakebread A, Cooper MS, Young JD, Blower PJ, Ma MT (2019) The effects of trace metal impurities on Ga-68-radiolabelling with a tris(3-hydroxy-1,6-dimethylpyridin-4-one) (THP) chelator RSC Advances 9: 37214-37221.
Lawson R, Maret W, Hogstrand C (2019) ZnT8 Haploinsufficiency Impacts MIN6 cell zinc content and β-cell phenotype via ZIP-ZnT8 coregulation Int. J. Mol. Sci. 21:5485.
2018 Publications
Pfeffer PE, Lu H, Mann EH, Chen YH, Ho TR, Cousins DJ, Corrigan C, Kelly FJ, Mudway IS, Hawrylowicz CM (2018) Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter. PLoS One 8:e0200040.
Prabhu PAJ, Stewart T, Silva M, Amlund H, Ørnsrud, R, Lock EJ, Waagbo R, Hogstrand C (2018) Zinc uptake in fish intestinal epithelial model RTgutGC: Impact of media ion composition and methionine chelation J Trace Elem Med Biol. 50:377-383.
Lawson R, Maret W, Hogstrand C (2018) Prolonged stimulation of insulin release from MIN6 cells causes zinc depletion and loss of β-cell markers J Trace Elem Med Biol. 49: 51-59.
Parsons D, Hogstrand C, Maret W (2018) The C-terminal cytosolic domain of the human zinc transporter ZnT8 and its diabetes risk variant FEBS Journal 285: 1237-1250.
Maret W (2018) Metallomics: The Science of Biometals and Biometalloids. Adv Exp Med Biol. 1055:1-20.
Bartnika JJ, Blower PJ (2018) Insights into Trace Metal Metabolism in Health and Disease from PET: PET Metallomics. J Nucl Med. 59:1355-1359.
Miyashita L, Suri R, Dearing E, Mudway I, Dove RE, Neill DR, Van Zyl-Smit R, Kadioglu A, Grigg J (2018) E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells. Eur Respir J. 51:1701592.
Jarvis IWH, Enlo-Scott Z, Nagy E, Mudway IS, Tetley TD, Arlt VM, Phillips DH (2018) Genotoxicity of fine and coarse fraction ambient particulate matter in immortalised normal (TT1) and cancer-derived (A549) alveolar epithelial cells. Environ Mol Mutagen. 59:290-301.
2017 Publications
Robinson RK, Birrell MA, Adcock JJ, Wortley MA, Dubuis ED, Chen S, McGilvery CM, Hu S, Shaffer MSP, Bonvini SJ, Maher SA, Mudway IS, Porter AE, Carlsten C, Tetley TD, Belvisi MG (2017) Mechanistic link between diesel exhaust particles and respiratory reflexes. J Allergy Clin Immunol. 141:1074-1084.
Mann EH, Ho TR, Pfeffer PE, Matthews NC, Chevretton E, Mudway I, Kelly FJ, Hawrylowicz CM (2017) Vitamin D Counteracts an IL-23-Dependent IL-17A+IFN-γ+ Response Driven by Urban Particulate Matter. Am J Respir Cell Mol Biol. 57:355-366.
Tsionou MI, Knapp CE, Foley CA, Munteanu CR, Cakebread A, Imberti C, Eykyn TR, Young JD, Paterson BM, Blower PJ, Ma MT (2017) Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling RSC Advances 7: 49586-49599.
da Silva JG, Babb R, Salzlechner C, Sharpe PT, Brauer DS, Gentleman E (2017) Optimisation of lithium-substituted bioactive glasses to tailor cell response for hard tissue repair Journal of Materials Science 52: 8832–8844.
2016 Publications
Samoli E, Atkinson RW, Analitis A, Fuller GW, Beddows D, Green DC, Mudway IS, Harrison RM, Anderson HR, Kelly FJ (2016) Differential health effects of short-term exposure to source-specific particles in London, UK. Environ Int. 97:246-253.
Atkinson RW, Samoli E, Analitis A, Fuller GW, Green DC, Anderson HR, Purdie E, Dunster C, Aitlhadj L, Kelly FJ, Mudway IS (2016) Short-term associations between particle oxidative potential and daily mortality and hospital admissions in London Int J Hyg Environ Health. 219:566-572.
Samoli E, Atkinson RW, Analitis A, Fuller GW, Green DC, Mudway I, Anderson HR, Kelly FJ (2016) Associations of short-term exposure to traffic-related air pollution with cardiovascular and respiratory hospital admissions in London, UK Occup Environ Med. 73:300-307.
Atkinson RW, Analitis A, Samoli E, Fuller GW, Green DC, Mudway IS, Anderson HR, Kelly FJ (2016) Short-term exposure to traffic-related air pollution and daily mortality in London UK 26:125–132.
Suri R, Periselneris J, Lanone S, Zeidler-Erdely PC, Melton G, Palmer KT, Andujar P, Antonini JM, Cohignac V, Erdely A, Jose RJ, Mudway I, Brown J, Grigg J (2016) Exposure to welding fumes and lower airway infection with Streptococcus pneumoniae. J Allergy Clin Immunol. 137:527-534.
The LMF is part of King's network of Core Facilities. We provide expert advice and bespoke service for analysis of metals, particularly in complex biological samples including experimental design and conceptualisation, sample preparation, measurement execution, data analysis and interpretation. We facilitate both bulk quantification through ICP-MS, and an imaging approach, through LA-ICP-MS, generating versatility for users. The LMF has developed unique data processing pipelines which output publication quality data and statistics.
We offer technical consultation and ongoing support to both the research and commercial communities, ensuring users achieve high-quality data outputs.
Facility staff
Manager - London Metallomics Facility
Deputy Manager, London Metallomics Facility
Mass Spectrometry Analyst, London Metallomics Facility
Affiliated academics
Lecturer in Imaging Chemistry
Professor of Metallomics
Professor of Imaging Chemistry and Head of Department of Imaging Chemistry and Biology
Business Development Manager (Core Facilities)
Professor of Vascular Physiology
Emeritus Professor
Professor of Nutritional Sciences
Reader in Biomedical Imaging and Spectroscopy
Professor of Toxicogenomics
Head of Centre for Oral, Clinical & Translational Sciences
Reader
Lecturer in Immunology and Drug Discovery
Reader in Cardiac Molecular Imaging
Professor of Molecular Ecotoxicology
We have a wide range of equipment available for use, including:
Related equipment
Vitesse ICP-TOF-MS
The Vitesse is a high-speed, time-of-flight ICP-MS, ideal for metallomic imaging and single-cell analysis, detecting most elements.
PerkinElmer NexION 5000 ICP-MS
NexION 5000: Multi-quadrupole ICP-MS for bulk solution analysis with high sensitivity, down to parts-per-quadrillion.
Thermofisher iCAP TQ ICP-MS
iCAP TQ: Triple quadrupole ICP-MS, ideal for imaging with laser ablation. Excels in sensitivity and interference control.
Teledyne Iridia Laser Ablation System
Iridia: 193 nm laser ablation system, 1-50 micron spot size, for soft to hard substrates. High-speed, sub-cellular imaging with ICP-MS.
Autosamplers
Autosamplers for ICP-MS: automate 240-sample batches for high-throughput analysis.
Bruker S2 PICOFOX TXRF
S2 PICOFOX TXRF: Portable, low pg/ppb sensitivity for small/matrix-rich liquid samples, versatile for various types.
Milestone Microwave Digestor
UltraWAVE: High-pressure microwave digestor for complex samples, no assembly or cleaning needed between uses.
Clean Room
The clean room within the facility includes a Metal free class 2 Biosafety cabinet and metal free laminar flow fume hood.
The London Metallomics Facility is a central hub for advanced metallomic analytics, promoting interaction between diverse areas of academic research, industry, and equipment manufacturers. It also plays a key role in education and training within this emerging field, providing necessary expertise and support to researchers.
King's Together Strategic Award - Metallomics Symposium 2021
The roles of metals in human health
Researchers at the LMF, backed by Wellcome Trust funding, are working on the cutting edge of inorganic biochemistry, with implications for how we understand, diagnose and treat human diseases like diabetes, cancer and Alzheimer’s disease.
Monday Science Podcast Interviews
Listen to Monday Science podcast interviews- featuring Dr. Theodora Stewart.
Awards
-
London Metallomics Facility - Wellcome Trust Multi-user Equipment Grant
-
Metallomic profiling and redox signalling in human coronary artery endothelial and smooth muscle cells in physiological normoxia and ischaemia/reperfusion injury - Heart Research UK
-
Multidimensional Metallomic Imaging for Environmental Hazard Analysis - Natural Environment Research Council
-
PET metallomics in cancer: predicting response to platinum drugs - Medical Research Council
-
Metallomic Profiling and Imaging for Understanding Skin and Scalp Biology - BBSRC LIDo
-
Metal Fingerprints in Normal Cell States and Disease - King's Together Strategic Award
- Integrated multi-modal tissue state mapping of TNBC progression-
2023 Publications
Smith M.J, Yang F, Griffiths A, Morrell A, Chapple S.J, Siow R.C.M, Stewart T, Maret, W, and Mann, G.E (2023) Redox and metal profiles in human coronary endothelial and smooth muscle cells under hyperoxia, physiological normoxia and hypoxia: effects of NRF2 signaling on intracellular zinc, j.redox.2023.102712.
Han S, Wang J.T-W, Yavuz E, Zam A, Rouatbi N, Utami R.N, Liam-Or, R, Griffiths A., Dickson W, Sosabowski J, Al-Jamal K.T, (2023). Spatiotemporal tracking of gold nanorods after intranasal administration for brain targeting, j.jconrel.2023.04.022.
Weston A, Vladescu S.C, Reddyhoff T, Griffiths A., Crouzier T., Fielden M, Garnett J.A, Carpenter G.H, (2023). The Influence of Ions on the Lubricative Abilities of Mucin and the Role of Sialic Acids, j.colsurfb.2023.113327.
Firth G, Georgiadou E, Griffiths A, Amrahli M, Kim J, Yu Z, Hu M, Stewart T, Leclerc I, Okamoto H, Gomez D, Blower P.J, Rutter G.A, (2023). Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice, fendo.2023.1171933.
Yang F, Smith M.J, Griffiths A, Morrell A, Chapple S.J, Siow R.C.M, Stewart T., Maret W, Mann G.E, (2023). Vascular protection afforded by zinc supplementation in human coronary artery smooth muscle cells mediated by NRF2 signalling under hypoxia/reoxygenation, j.redox.2023.102777.
Morrell A.P, Martin R.M, Roberts H.M, Castillo-Michel H., Mosselmans J.F.W, Geraki K, Warfield A.T, Lingor P, Qayyum W, Graf D, Febbraio M, Addison O, (2023). Addressing uncertainties in correlative imaging of exogenous particles with the tissue microanatomy with synchronous imaging strategies, mfad030.
2022 Publications
Wan Y, Stewart T, Amrahli M, Evans J, Sharp P, Govindan V, Hawkesford MJ, Shewry PR, (2022) Localisation of iron and zinc in grain of biofortified wheat, J. Cereal Sci. in press.
2021 Publications
Goncalves J., Moog S, Morin A, Gentric G, Müller S, Morrell AP, Kluckova K, Stewart TJ, Andoniadou CL, Lussey-Lepoutre C, Bénit P, Thakker A, Vettore L, Roberts J, Rodriguez R, Mechta-Grigoriou F, Gimenez-Roqueplo AP, Letouzé E, Tennant DA, Favier J (2021) Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate, Cancer Res. 81:3480–3494.
Unosson J, Kabéle M, Boman C, Nyström R, Sadiktsis I, Westerholm R, Mudway IS, Purdie E, Raftis J, Miller MR, Mills NL, Newby DE, Blomberg A, Sandström T, Bosson JA (2021) Acute cardiovascular effects of controlled exposure to dilute Petrodiesel and biodiesel exhaust in healthy volunteers: a crossover study. Part Fibre Toxicol. 18:22.
Osytek KM, Blower PJ, Costa IM, Smith GE, Abbate V, Terry SYA (2021) In vitro proof of concept studies of radiotoxicity from Auger electron-emitter thallium-201 EJNMMI Res 11: 63.
Alaohali A, Brauer DS, Gentleman E, Sharpe PT (2021) A modified glass ionomer cement to mediate dentine repair Dental Materials 37:1307-1315.
Frangos T, Maret W (2021) Zinc and Cadmium in the Aetiology and Pathogenesis of Osteoarthritis and Rheumatoid Arthritis. Nutrients. 13:53.
2020 Publications
Ashraf A, Jeandriens J, Parkes HG, So PW (2020) Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer's disease: Evidence of ferroptosis. Redox Biology 32:101494.
Kutscher D, Asogan D, Mudway I, Brekke P, Beales C, Wang X, Perkins M, Maret W, Stewart T (2020) Imaging of Trace Elements Using Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry: Emerging New Applications Spectroscopy 35:16–26.
Muraina IA, Bury NR, Scott A, Graham A, Hogstrand C (2020) The zebrafish Znt1asa17 mutant reveals roles of zinc transporter-1a in embryonic development. J. Trace Elem. Med. Biol. 60:126496.
Selley L, Schuster L, Marbach H, Forsthuber T, Forbes B, Gant TW, Sandstrom T, Camina N, Athersuch TJ, Mudway I, Kumar A (2020) Brake dust exposure exacerbates inflammation and transiently compromises phagocytosis in macrophages. Metallomics. 12:371-386.
2019 Publications
Fitzgerald JA, Urbina MG, Rogers NJ, Bury NR, Katsiadaki I, Wilson RW, Santos EM (2019) Sublethal exposure to copper supresses the ability to acclimate to hypoxia in a model fish species. Aquatic Toxicology 217:105325.
Stewart TJ (2019) Across the spectrum: integrating multidimensional metal analytics for in situ metallomic imaging. Metallomics. 11:29–49.
Zhang K, Alaohali A, Sawangboon N, Sharpe PT, Brauer DS, Gentleman E (2019) A comparison of lithium-substituted phosphate and borate bioactive glasses for mineralised tissue repair Dental Materials 35: 919-927.
Maret W (2019) The redox biology of redox-inert zinc ions. Free Radic Biol Med. 134:311-326.
Koppenol WH, Hider R (2019) Iron and redox cycling. Do's and don'ts. Free Radic Biol Med. 133:3-10.
Kose T, Vera-Aviles M, Sharp PA, Latunde-Dada GO (2019) Curcumin and (−)- Epigallocatechin-3-Gallate Protect Murine MIN6 Pancreatic Beta-Cells against Iron Toxicity and Erastin-Induced Ferroptosis Pharmaceuticals. 12: 26.
Ashraf A, Stosnach H, Parkes HG, Hye A, Powell J, So PW (2019) Pattern of Altered Plasma Elemental Phosphorus, Calcium, Zinc, and Iron in Alzheimer’s Disease. Scientific Reports 9:3147.
Cusnir R, Cakebread A, Cooper MS, Young JD, Blower PJ, Ma MT (2019) The effects of trace metal impurities on Ga-68-radiolabelling with a tris(3-hydroxy-1,6-dimethylpyridin-4-one) (THP) chelator RSC Advances 9: 37214-37221.
Lawson R, Maret W, Hogstrand C (2019) ZnT8 Haploinsufficiency Impacts MIN6 cell zinc content and β-cell phenotype via ZIP-ZnT8 coregulation Int. J. Mol. Sci. 21:5485.
2018 Publications
Pfeffer PE, Lu H, Mann EH, Chen YH, Ho TR, Cousins DJ, Corrigan C, Kelly FJ, Mudway IS, Hawrylowicz CM (2018) Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter. PLoS One 8:e0200040.
Prabhu PAJ, Stewart T, Silva M, Amlund H, Ørnsrud, R, Lock EJ, Waagbo R, Hogstrand C (2018) Zinc uptake in fish intestinal epithelial model RTgutGC: Impact of media ion composition and methionine chelation J Trace Elem Med Biol. 50:377-383.
Lawson R, Maret W, Hogstrand C (2018) Prolonged stimulation of insulin release from MIN6 cells causes zinc depletion and loss of β-cell markers J Trace Elem Med Biol. 49: 51-59.
Parsons D, Hogstrand C, Maret W (2018) The C-terminal cytosolic domain of the human zinc transporter ZnT8 and its diabetes risk variant FEBS Journal 285: 1237-1250.
Maret W (2018) Metallomics: The Science of Biometals and Biometalloids. Adv Exp Med Biol. 1055:1-20.
Bartnika JJ, Blower PJ (2018) Insights into Trace Metal Metabolism in Health and Disease from PET: PET Metallomics. J Nucl Med. 59:1355-1359.
Miyashita L, Suri R, Dearing E, Mudway I, Dove RE, Neill DR, Van Zyl-Smit R, Kadioglu A, Grigg J (2018) E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells. Eur Respir J. 51:1701592.
Jarvis IWH, Enlo-Scott Z, Nagy E, Mudway IS, Tetley TD, Arlt VM, Phillips DH (2018) Genotoxicity of fine and coarse fraction ambient particulate matter in immortalised normal (TT1) and cancer-derived (A549) alveolar epithelial cells. Environ Mol Mutagen. 59:290-301.
2017 Publications
Robinson RK, Birrell MA, Adcock JJ, Wortley MA, Dubuis ED, Chen S, McGilvery CM, Hu S, Shaffer MSP, Bonvini SJ, Maher SA, Mudway IS, Porter AE, Carlsten C, Tetley TD, Belvisi MG (2017) Mechanistic link between diesel exhaust particles and respiratory reflexes. J Allergy Clin Immunol. 141:1074-1084.
Mann EH, Ho TR, Pfeffer PE, Matthews NC, Chevretton E, Mudway I, Kelly FJ, Hawrylowicz CM (2017) Vitamin D Counteracts an IL-23-Dependent IL-17A+IFN-γ+ Response Driven by Urban Particulate Matter. Am J Respir Cell Mol Biol. 57:355-366.
Tsionou MI, Knapp CE, Foley CA, Munteanu CR, Cakebread A, Imberti C, Eykyn TR, Young JD, Paterson BM, Blower PJ, Ma MT (2017) Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling RSC Advances 7: 49586-49599.
da Silva JG, Babb R, Salzlechner C, Sharpe PT, Brauer DS, Gentleman E (2017) Optimisation of lithium-substituted bioactive glasses to tailor cell response for hard tissue repair Journal of Materials Science 52: 8832–8844.
2016 Publications
Samoli E, Atkinson RW, Analitis A, Fuller GW, Beddows D, Green DC, Mudway IS, Harrison RM, Anderson HR, Kelly FJ (2016) Differential health effects of short-term exposure to source-specific particles in London, UK. Environ Int. 97:246-253.
Atkinson RW, Samoli E, Analitis A, Fuller GW, Green DC, Anderson HR, Purdie E, Dunster C, Aitlhadj L, Kelly FJ, Mudway IS (2016) Short-term associations between particle oxidative potential and daily mortality and hospital admissions in London Int J Hyg Environ Health. 219:566-572.
Samoli E, Atkinson RW, Analitis A, Fuller GW, Green DC, Mudway I, Anderson HR, Kelly FJ (2016) Associations of short-term exposure to traffic-related air pollution with cardiovascular and respiratory hospital admissions in London, UK Occup Environ Med. 73:300-307.
Atkinson RW, Analitis A, Samoli E, Fuller GW, Green DC, Mudway IS, Anderson HR, Kelly FJ (2016) Short-term exposure to traffic-related air pollution and daily mortality in London UK 26:125–132.
Suri R, Periselneris J, Lanone S, Zeidler-Erdely PC, Melton G, Palmer KT, Andujar P, Antonini JM, Cohignac V, Erdely A, Jose RJ, Mudway I, Brown J, Grigg J (2016) Exposure to welding fumes and lower airway infection with Streptococcus pneumoniae. J Allergy Clin Immunol. 137:527-534.
Partners
The LMF works closely with companies to advance our analytical capabilities, directly informed by the needs of our users. We acknowledge funding from Heart Research UK, British Heart Foundation, Biotechnology and Biological Sciences Research Council, Medical Research Council, King's College London and Wellcome Trust.
King's College London is hosting the 9th International Symposium on Metallomics this June 2024. For information check out the website, and follow us on X, Facebook and LinkedIn.
We work with
Teledyne CETAC Technologies
Nu Instruments
Perkin Elmer
ThermoFisher Scientific
Euro BioImaging
