Professor James McDonnell Academics Professor of Molecular Immunology Contact details james.mcdonnell@kcl.ac.uk +44 (0) 02 7848 6970
Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs) Hoffmann, R. M., Mele, S., Cheung, A., Larcombe-Young, D., Bucaite, G., Sachouli, E., Zlatareva, I., Morad, H. O. J., Marlow, R., McDonnell, J. M., Figini, M., Lacy, K. E., Tutt, A. J. N., Spicer, J. F., Thurston, D. E., Karagiannis, S. N. & Crescioli, S., 1 Jun 2020, In : Scientific Reports. 10, 1, p. 8869 8869. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41598-020-65860-x Rapid conjugation of antibodies to toxins to select candidates for the development of anti-cancer Antibody-Drug Conjugates (ADCs) Hoffmann, M., Mele, S., Cheung, A., Larcombe-Young, D., Bucaite, G., Sachouli, E., Zlatareva, I., Morad, H., Marlow, R., McDonnell, J., Figini, M., Lacy, K. E., Tutt, A., Spicer, J., Thurston, D., Karagiannis, S. N. & Crescioli, S., 9 May 2020, (Accepted/In press) In : Scientific Reports. 22 p. Research output: Contribution to journal - Article NMR backbone assignment of the Cε4 domain of immunoglobulin E Benjamin, S. V., Creeke, P. I., Henry, A. J. & McDonnell, J. M., 1 Apr 2020, In : Biomolecular NMR Assignments. 14, 1, p. 151-155 5 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1007/s12104-020-09936-9 Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization Mitropoulou, A., Ceska, T., Heads, J., Beavil, A., Henry, A. J., McDonnell, J., Sutton, B. & Davies, A. M., 1 Mar 2020, In : Acta Crystallographica Section F:Structural Biology Communications. 76, p. 116-129 14 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1107/S2053230X20001466 Interplay between Affinity and Valency in Effector Cell Degranulation: A Model System with Polcalcin Allergens and Human Patient-Derived IgE Antibodies Bucaite, G., Kang-Pettinger, T., Moreira, J., Gould, H. J., James, L. K., Sutton, B. J. & McDonnell, J. M., 1 Oct 2019, In : Journal of Immunology. 203, 7, p. 1693-1700 8 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.4049/jimmunol.1900509 Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10 Dimeloe, S., Rice, L. V., Chen, H., Cheadle, C., Raynes, J., Pfeffer, P., Lavender, P., Richards, D. F., Nyon, M. P., Mcdonnell, J. M., Kemper, C., Gooptu, B. & Hawrylowicz, C. M., May 2019, In : Journal of Steroid Biochemistry and Molecular Biology. 189, p. 1-9 9 p., SBMB_2018_497. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.jsbmb.2019.01.014 A mass spectrometry-based modelling workflow for accurate prediction of IgG antibody conformations in the gas phase Hansen, K., Lau, A. M. C., Giles, K., McDonnell, J. M., Struwe, WB., Sutton, B. J. & Politis, A., 21 Dec 2018, In : ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 57, 52, p. 17194-17199 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1002/anie.201812018 Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody Chen, J-B., Ramadani, F., Pang, M. O. Y., Beavil, R. L., Holdom, M. D., Mitropoulou, A. N., Beavil, A. J., Gould, H. J., Chang, T. W., Sutton, B. J., McDonnell, J. M. & Davies, A. M., 1 Aug 2018, In : Scientific Reports. 8, 1, 11548. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41598-018-29664-4 Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation Doré, K. A., Kashiwakura, J., McDonnell, J. M., Gould, H. J., Kawakami, T., Sutton, B. J. & Davies, A. M., Jan 2018, In : Molecular Immunology. 93, p. 216-222 7 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.molimm.2017.11.022 Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G Pollpeter, D., Parsons, M., Sobala, A., Coxhead, S., Lang, R. D., Bruns, A. M., Papaioannou, S., McDonnell, J. M., Apolonia, L., Chowdhury, J. A., Horvath, C. M. & Malim, M., 2018, In : Nature Microbiology. 3, p. 220-233 14 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41564-017-0063-9 View all publications