The McDonnell Laboratory studies the molecules and molecular interactions that control allergic and inflammatory immune responses. The group uses molecular, structural, biophysical and computational methods to elucidate the mechanisms of pathological immune responses. Based on the understanding of interaction mechanisms, the lab designs and develops inhibitors of molecular interactions, employing structure-based design and library screening approaches. Inhibitors are used both as investigative tools and developed further as novel immunotherapeutic agents.
Projects

Immunoglobulin E: structure, interactions and allostery
Immunoglobulin E (IgE) is the antibody isotype that mediates allergic immune reactions. For many years we have studied the IgE molecule, its three-dimensional structure and its interactions with other molecules. Recently, this work has led to the development of novel anti-IgE drugs for the treatment of allergic disorders.

The structure and function of immunoglobulin D
Immunoglobulin D (IgD) remains the most enigmatic of all antibody isotypes. Recent evidence indicate activity of IgD in the bronchial mucosa, and potential regulatory roles in allergy.

Interactions of IgE with parasite antigens
Although IgE is best known for its role in mediating allergic immune responses, its natural role is probably to rapidly rid the body of invading parasites. New research in the lab seeks to better understand the molecular interactions that control IgE-mediated anti-parasite immune responses.
Publications
Projects

Immunoglobulin E: structure, interactions and allostery
Immunoglobulin E (IgE) is the antibody isotype that mediates allergic immune reactions. For many years we have studied the IgE molecule, its three-dimensional structure and its interactions with other molecules. Recently, this work has led to the development of novel anti-IgE drugs for the treatment of allergic disorders.

The structure and function of immunoglobulin D
Immunoglobulin D (IgD) remains the most enigmatic of all antibody isotypes. Recent evidence indicate activity of IgD in the bronchial mucosa, and potential regulatory roles in allergy.

Interactions of IgE with parasite antigens
Although IgE is best known for its role in mediating allergic immune responses, its natural role is probably to rapidly rid the body of invading parasites. New research in the lab seeks to better understand the molecular interactions that control IgE-mediated anti-parasite immune responses.
Publications
Our Partners

Biotechnology and Biological Sciences Research Council (UKRI)

Asthma UK

UCB Pharma

Asthma UK Centre in Allergic Mechanisms of Asthma