I am a Senior Lecturer in Molecular Dermatology leading a research team at St. John's Institute of Dermatology, King's College London. Since 2024, I have been a Fellow of the Higher Education Academy (FHEA) and contribute regularly to teaching and education in the university. My research career began with a PhD in Molecular Dermatology from the Albert-Ludwig University in Freiburg, Germany. Following postdoctoral fellowships at the Imagine Institute in Paris and Columbia University in New York, I joined King's College London in 2020 as a tenured faculty member. My research focuses on developing novel treatment strategies for inherited diseases and skin cancer.

My expertise encompasses molecular biology, biochemistry, and developmental biology. My laboratory combines gene editing technologies and lipid nanoparticles to develop treatments that repair causal genetic defects in monogenic diseases, including recessive dystrophic epidermolysis bullosa (RDEB), which is an inherited skin fragility disorder strongly associated with the development of fatal skin cancers. We also employ 3D in vitro models, such as spheroids, to better understand the immunopathogenesis of skin cancer in RDEB.

Current Research Projects

• Development and testing of gene editing for epidermolytic ichthyosis

  McGrath, J. (Primary Investigator) & Jackow, J. (Co-Investigator)

  Rosetrees Trust

  1/06/2025 → 31/05/2028

  Project: Research

• Evaluation of long-term effect on skin homeostasis and regeneration in a RDEB mouse model using different delivery methods of LNP's encapsulating mRNA-based base editing approach.

  Jackow, J. (Primary Investigator) & McGrath, J. (Co-Investigator)

  Cure EB

  1/06/2025 → 31/05/2028

  Project: Research

• Validating new anti-cancer targets for dystrophic epidermolysis bullosa using patients derived skin organoids

  Jackow, J. (Primary Investigator) & Karagiannis, S. (Co-Investigator)

  EB Research Partnership

  1/06/2025 → 31/05/2028

  Project: Research

• Investigation of lipid-mediated disease mechanisms underpinning solar urticaria

  McGrath, J. (Primary Investigator), Jackow, J. (Co-Investigator) & McSweeney, S. (Co-Investigator)

  British Skin Foundation

  1/09/2024 → 31/08/2025

  Project: Research

• PASTE-Mediated Superexon Replacement of COL7A1 as a Treatment for Epidermolysis Bullosa

  Jackow, J. (Primary Investigator) & McGrath, J. (Co-Investigator)

  DEBRA UK

  16/01/2024 → 15/01/2026

  Project: Research

• Prenatal ThERapy for SIckle CelL DisEaSe (PERICLES)

  Shangaris, P. (Primary Investigator), Chiappini, C. (Co-Investigator), El Hoss, S. (Co-Investigator), Jackow, J. (Co-Investigator), Lombardi, G. (Co-Investigator) & Nicolaides, K. (Co-Investigator)

  FETAL MEDICINE FOUNDATION

  1/12/2023 → 30/11/2027

  Project: Research

• Testing the in vivo efficacy of base and prime editing in primary fibroblasts and in a 3D skin model of dystrophic epidermolysis bullosa

  Jackow, J. (Primary Investigator) & McGrath, J. (Co-Investigator)

  Cure EB

  1/09/2022 → 30/09/2027

  Project: Research

• Development of a drug testing platform for recessive dystrophic epidermolysis bullosasquamous cell carcinoma using induced pluripotent cancer cells

  Jackow, J. (Primary Investigator)

  EB Research Partnership

  1/12/2020 → 30/11/2026

  Project: Research

• Development of a drug testing platform for recessive dystrophic epidermolysis bullosasquamous cell carcinoma using induced pluripotent cancer cells

  Jackow, J. (Primary Investigator)

  EB Medical Research Foundation

  1/12/2020 → 30/11/2026

  Project: Research

• Finished

  Testing the efficacy of genomic base editing in dystrophic epidermolysis bullosa primary fibroblasts

  Jackow, J. (Primary Investigator)

  Cure EB

  1/04/2021 → 31/03/2022

  Project: Research