
Professor Jonathan Barker MD FRCP FRCPath
Professor of Medical Dermatology
Biography
Jonathan Barker qualified in Medicine at Guy’s Hospital in 1981. Having completed his internal medicine training (MRCP 1985) he undertook Dermatology training in the Department of Dermatology, Guy’s Hospital, from 1985 to 1991, including a Senior Research Fellowship in the Department of Dermatology and Pathology at the University of Michigan, USA (1989-90). In 1991 he was appointed Senior Lecturer in Dermatology and Honorary Consultant Dermatologist at St John’s Institute of Dermatology. In 2000 he was promoted to Professor of Clinical Dermatology. Professor Barker has been Academic Head of St John’s Institute of Dermatology from 2002 until August 2018.
Professor Barker sits on the Editorial Board of several scientific journals. He is heavily involved in postgraduate education, for example through his chairmanship of the Annual Course for UK Dermatologists. He also plays a prominent role in international dermatology. He is presently President of the European Dermatology Forum, having been Secretary-General since 2003. He is a Director of the International Psoriasis Council (2006-present).
Genetic Risk Factors in Childhood Psoriasis
Schwarz, C. W., Blegvad, C., Baudry, D., Tosi, I., Lee, S.-H., Chung, R., Tato-Barcia, E., Curtis, C. J., Smith, C. H., Simpson, M. A., Nybo Andersen, A.-M., Barker, J. N., Di Meglio, P., Skov, L. & Dand, N., 19 Feb 2025, (E-pub ahead of print) In: Journal of Investigative Dermatology.Research output: Contribution to journal › Article › peer-review
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
Dand, N., Stuart, P. E., Bowes, J., Ellinghaus, D., Nititham, J., Saklatvala, J. R., Teder-Laving, M., Thomas, L. F., Traks, T., Uebe, S., Assmann, G., Baudry, D., Behrens, F., Billi, A. C., Brown, M. A., Burkhardt, H., Capon, F., Chung, R., Curtis, C. J. & Duckworth, M. & 30 others, Ellinghaus, E., FitzGerald, O., Gerdes, S., Griffiths, C. E. M., Gulliver, S., Helliwell, P. S., Ho, P., Hoffmann, P., Holmen, O. L., Huang, Z.-M., Hveem, K., Jadon, D., Köhm, M., Kraus, C., Lamacchia, C., Lee, S. H., Ma, F., Mahil, S. K., McHugh, N., McManus, R., Modalsli, E. H., Nissen, M. J., Nöthen, M., Oji, V., Oksenberg, J. R., Patrick, M. T., Smith, C. H., Di Meglio, P., Barker, J. N. & Simpson, M. A., 28 Feb 2025, In: Nature Communications. 16, 1, 1 p., 2051.Research output: Contribution to journal › Article › peer-review
Personalizing Biologic Therapy in Psoriasis: Development, Validation, and User Testing of a Precision-Dosing Dashboard
Thomas, C., Baudry, D., Arkir, Z., Coker, B., Dasandi, T., Powell, K., Arenas-Hernandez, M., Leung, J., Rawstron, K., Nwaogu, C., Chapman, S., Woolf, R., Pink, A. E., Barker, J., Standing, J. F., Smith, C. H. & Mahil, S., 19 Feb 2025, (E-pub ahead of print) In: Journal of Investigative Dermatology.Research output: Contribution to journal › Article › peer-review
Prevalence of comorbidity amongst people with palmoplantar pustulosis: A systematic review and meta-analysis
Gleeson, D., Corbett, M., Choy, S. P., Jiang, T., Lee, J. Y. W., Bechman, K., Russell, M. D., Barker, J. N., Galloway, J. B., Smith, C. H. & Mahil, S. K., 12 May 2025, (Accepted/In press) In: Journal of the European Academy of Dermatology and Venereology.Research output: Contribution to journal › Letter › peer-review
Acceptability of 'as needed' biologic therapy in psoriasis: insights from a multi-stakeholder mixed methods study
Gleeson, D., Naveed, M., Moorhead, L., McAteer, H., Sewell, G., McGuire, A., Weinman, J., Barker, J. N. W. N., Norton, S., Chapman, S. C. E., Smith, C. H. & Mahil, S. K., 1 Aug 2024, In: The British journal of dermatology. 191, 2, p. 243-251 9 p.Research output: Contribution to journal › Article › peer-review
A genome-wide meta-analysis of palmoplantar pustulosis implicates Th2 responses and cigarette smoking in disease pathogenesis
APRICOT and PLUM study team, Sept 2024, In: Journal of Allergy and Clinical Immunology. 154, 3, p. 657-665.e9Research output: Contribution to journal › Article › peer-review
Defining disease severity in atopic dermatitis and psoriasis for the application to biomarker research: an interdisciplinary perspective
Ramessur, R., Dand, N., Langan, S. M., Saklatvala, J., Fritzsche, M.-C., Holland, S., Arents, B. W. M., McAteer, H., Proctor, A., McMahon, D., Greenwood, M., Buyx, A. M., Messer, T., Weiler, N., Hicks, A., Hecht, P., Weidinger, S., Ndlovu, M. N., Chengliang, D. & Hübenthal, M. & 10 others, Egeberg, A., Paternoster, L., Skov, L., De Jong, E. M. G. J., Middelkamp-Hup, M. A., Mahil, S. K., Barker, J. N., Flohr, C., Brown, S. J. & Smith, C. H., 20 Jun 2024, In: The British journal of dermatology. 191, 1, p. 14-23 10 p.Research output: Contribution to journal › Review article › peer-review
Exploring the Link Between Genetic Predictors of Cardiovascular Disease and Psoriasis
Ramessur, R., Saklatvala, J., Budu-Aggrey, A., Ostaszewski, M., Möbus, L., Greco, D., Ndlovu, M., Mahil, S. K., Barker, J. N., Brown, S., Paternoster, L., Dand, N., Simpson, M. A. & Smith, C. H., 18 Sept 2024, In: JAMA Cardiology. 9, 11, p. 1009-1017 9 p.Research output: Contribution to journal › Article › peer-review
International Consensus Definition and Diagnostic Criteria for Generalized Pustular Psoriasis from the International Psoriasis Council
Choon, S. E., Van De Kerkhof, P., Gudjonsson, J. E., De La Cruz, C., Barker, J., Morita, A., Romiti, R., Affandi, A. M., Asawanonda, P., Burden, A. D., Gonzalez, C., Marrakchi, S., Mowla, M. R., Okubo, Y., Oon, H. H., Terui, T., Tsai, T. F., Callis-Duffin, K., Fujita, H. & Jo, S. J. & 14 others, Merola, J., Mrowietz, U., Puig, L., Thaçi, D., Velásquez, M., Augustine, M., El Sayed, M., Navarini, A. A., Pink, A., Prinz, J., Turki, H., Magalhães, R., Capon, F. & Bachelez, H., 17 Jul 2024, In: JAMA dermatology. 160, 7, p. 758-768 11 p.Research output: Contribution to journal › Review article › peer-review
Single-cell analysis of psoriasis resolution demonstrates an inflammatory fibroblast state targeted by IL-23 blockade
Francis, L., McCluskey, D., Ganier, C., Jiang, T., Du-Harpur, X., Gabriel, J., Dhami, P., Kamra, Y., Visvanathan, S., Barker, J., Smith, C. H., Capon, F. & Mahil, S., 30 Jan 2024, In: Nature Communications. 15, 1, 913.Research output: Contribution to journal › Article › peer-review
Are Janus kinase inhibitors an effective treatment for palmoplantar pustulosis? A critically appraised topic
Gleeson, D., Barker, J. N. W. N., Capon, F., Pink, A. E., Woolf, R. T., Smith, C. H. & Mahil, S. K., Apr 2023, In: The British journal of dermatology. 188, 4, p. 471-473 3 p.Research output: Contribution to journal › Article › peer-review
Characteristics of "Super-Responders" and "Super-Non-Responders" to First Biologic Monotherapy for Psoriasis: A Nested Case-control Study
BADBIR Study Group, 11 Nov 2023, (E-pub ahead of print) In: The British journal of dermatology.Research output: Contribution to journal › Article › peer-review
Clinical profile of patients with acute generalized pustular psoriasis with and without IL36RN mutations in multi-ethnic Johor Bahru, Malaysia
Choon, S. E., Tok, P. S. K., Wong, K. W., Lim, Y. T., Nanu, N. M., Barker, J. N. & Capon, F., Aug 2023, In: Experimental Dermatology. 32, 8, p. 1263-1271 9 p.Research output: Contribution to journal › Article › peer-review
Comorbidities of Keloid and Hypertrophic Scars Among Participants in UK Biobank: Comorbidities of excessive scarring
Ung, C. Y., Warwick, A. N., Onoufriadis, A., Barker, J., Parsons, M., McGrath, J., Shaw, T. & Dand, N., 4 Jan 2023, In: JAMA dermatology. 159, 2, p. 172-181 10 p.Research output: Contribution to journal › Article › peer-review
Damaging Alleles Affecting Multiple CARD14 Domains Are Associated with Palmoplantar Pustulosis
The APRICOT and PLUM study team, Mar 2023, In: Journal of Investigative Dermatology. 143, 3, p. 504-508.e5Research output: Contribution to journal › Article › peer-review
Development of antidrug antibodies against adalimumab maps to variation within the HLA-DR peptide-binding groove
Biomarkers of Systemic Treatment Outcomes in Psoriasis (BSTOP) Study Group, Tsakok, T., Saklatvala, J., Rispens, T., Loeff, F. C., de Vries, A., Allen, M. H., Barbosa, I. A., Baudry, D., Dasandi, T., Duckworth, M., Meynell, F., Russell, A., Chapman, A., McBride, S., McKenna, K., Perera, G., Ramsay, H., Ramesh, R. & Sands, K. & 10 others, Shipman, A., Burden, A. D., Griffiths, C. E., Reynolds, N. J., Warren, R. B., Mahil, S., Barker, J., Dand, N., Smith, C. & Simpson, M. A., 22 Feb 2023, In: JCI Insight. 8, 4, e156643.Research output: Contribution to journal › Article › peer-review
Genetic validation of psoriasis phenotyping in UK Biobank supports the utility of self-reported data and composite definitions for large genetic and epidemiological studies
Saklatvala, J. R., Hanscombe, K. B., Mahil, S. K., Tsoi, L. C., Elder, J. T., Barker, J. N., Simpson, M. A., Smith, C. H. & Dand, N., Aug 2023, In: Journal of Investigative Dermatology. 143, 8, p. 1598-1601.e10Research output: Contribution to journal › Letter › peer-review
Manuka honey activates the Aryl Hydrocarbon receptor: implications for skin inflammation
Alangari, A. A., Ashoori, M. D., Alwan, W., Dawe, H., Stockinger, B., Barker, J. N., Wincent, E. & Di Meglio, P., Aug 2023, In: Pharmacological Research. 194, 106848.Research output: Contribution to journal › Article › peer-review
Nonadherence to systemic immune-modifying therapy in people with psoriasis during the COVID-19 pandemic: findings from a global cross-sectional survey
PsoProtect study group, 20 Apr 2023, In: The British journal of dermatology. 188, 5, p. 610-617 8 p.Research output: Contribution to journal › Article › peer-review
Biomarkers of disease progression in people with psoriasis: a scoping review
Ramessur, R., Corbett, M., Marshall, D., Acencio, M., Biscaia De Andrade Barbosa, I., Dand, N., Di Meglio, P., Haddad, S., Jensen, A., Koopmann, W., Mahil, S., Ostaszewski, M., Rahmatulla, S., Rastrick, J., Saklatvala, J., Weidinger, S., Wright, K., Eyerich, K., Ndlovu, M. & Barker, J. & 3 others, Skov, L., Conrad, C. & Smith, C., Oct 2022, In: British Journal of Dermatology. 187, 4, p. 481-493 13 p.Research output: Contribution to journal › Article › peer-review
Biomarkers of systemic treatment response in people with psoriasis: a scoping review
BIOMAP Consortium, Corbett, M., Ramessur, R., Marshall, D., Acencio, M. L., Ostaszewski, M., Barbosa, I. A., Dand, N., Di Meglio, P., Haddad, S., Jensen, A. H. M., Koopmann, W., Mahil, S. K., Rahmatulla, S., Rastrick, J., Saklatvala, J., Weidinger, S., Wright, K., Eyerich, K. & Barker, J. N. & 4 others, Ndlovu, M., Conrad, C., Skov, L. & Smith, C. H., Oct 2022, In: British Journal of Dermatology. 187, 4, p. 494-506 13 p.Research output: Contribution to journal › Article › peer-review
Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling
the BADBIR Study Group & the BSTOP study group, Sept 2022, In: Arthritis and Rheumatology. 74, 9, p. 1535-1543 9 p.Research output: Contribution to journal › Article › peer-review
Differences in Clinical Features and Comorbid Burden between HLA-C∗06:02 Carrier Groups in >9,000 People with Psoriasis
BADBIR & BSTOP Study Groups, Jun 2022, In: Journal of Investigative Dermatology. 142, 6, p. 1617-1628.e10Research output: Contribution to journal › Article › peer-review
Humoral and cellular immunogenicity to a second dose of COVID-19 vaccine BNT162b2 in people receiving methotrexate or targeted immunosuppression: a longitudinal cohort study
Mahil, S. K., Bechman, K., Raharja, A., Domingo-Vila, C., Baudry, D., Brown, M. A., Cope, A. P., Dasandi, T., Graham, C., Khan, H., Lechmere, T., Malim, M. H., Meynell, F., Pollock, E., Sychowska, K., Barker, J. N., Norton, S., Galloway, J. B., Doores, K. J. & Tree, T. & 1 others, Smith, C. H., Jan 2022, In: The Lancet Rheumatology. 4, 1, p. e42-e52Research output: Contribution to journal › Article › peer-review
Influence of FLG loss-of-function mutations in host–microbe interactions during atopic skin inflammation
Oláh, P., Szlávicz, E., Kuchner, M., Nemmer, J., Zeeuwen, P., Lefèvre-Utile, A., Fyhrquist, N., Prast-Nielsen, S., Skoog, T., Serra, A., Rodríguez, E., Raap, U., Meller, S., Gyulai, R., Hupé, P., Kere, J., Levi-Schaffer, F., Tsoka, S., Alexander, H. & Nestle, F. O. & 11 others, Schröder, J. M., Weidinger, S., van den Bogaard, E., Soumelis, V., Greco, D., Barker, J., Lauerma, A., Ranki, A., Andersson, B., Alenius, H. & Homey, B., Jun 2022, In: Journal of Dermatological Science. 106, 3, p. 132-140 9 p.Research output: Contribution to journal › Article › peer-review
Single-cell analysis implicates Th17 to Th2 cell plasticity in the pathogenesis of palmoplantar pustulosis
APRICOT and PLUM study team, Oct 2022, In: Journal of Allergy and Clinical Immunology. 150, 4, p. 882-893 12 p.Research output: Contribution to journal › Article › peer-review
Vaccine hesitancy and access to psoriasis care during the COVID-19 pandemic: findings from a global patient-reported cross-sectional survey
PsoProtect study group, Bechman, K., Cook, E. S., Dand, N., Yiu, Z. Z. N., Tsakok, T., Meynell, F., Coker, B., Vincent, A., Bachelez, H., Barbosa, I., Brown, M. A., Capon, F., Contreras, C. R., De La Cruz, C., Di Meglio, P., Gisondi, P., Jullien, D., Kelly, J. & Lambert, J. & 20 others, Lancelot, C., Langan, S. M., Mason, K. J., McAteer, H., Moorhead, L., Naldi, L., Norton, S., Puig, L., Spuls, P. I., Torres, T., Urmston, D., Vesty, A., Warren, R. B., Waweru, H., Weinman, J., Griffiths, C. M., Barker, J. N., Smith, C. H., Galloway, J. B. & Mahil, S. K., Aug 2022, In: The British journal of dermatology. 187, 2, p. 254-256 3 p.Research output: Contribution to journal › Article › peer-review
Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two-staged, adaptive placebo-controlled trial (APRICOT)
the APRICOT Study Group, 12 Oct 2021, (E-pub ahead of print) In: British Journal of Dermatology.Research output: Contribution to journal › Article › peer-review
Application of information theoretic feature selection and machine learning methods for the development of genetic risk prediction models
BADBIR Study Group & BSTOP study group, Dec 2021, In: Scientific Reports. 11, 1, 23335.Research output: Contribution to journal › Article › peer-review
Association between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death among Patients with Immune-Mediated Inflammatory Disease and COVID-19
Izadi, Z., Brenner, E. J., Mahil, S. K., Dand, N., Yiu, Z. Z. N., Yates, M., Ungaro, R. C., Zhang, X., Agrawal, M., Colombel, J. F., Gianfrancesco, M. A., Hyrich, K. L., Strangfeld, A., Carmona, L., Mateus, E. F., Lawson-Tovey, S., Klingberg, E., Cuomo, G., Caprioli, M. & Cruz-Machado, A. R. & 45 others, Mazeda Pereira, A. C., Hasseli, R., Pfeil, A., Lorenz, H. M., Hoyer, B. F., Trupin, L., Rush, S., Katz, P., Schmajuk, G., Jacobsohn, L., Seet, A. M., Al Emadi, S., Wise, L., Gilbert, E. L., Duarte-García, A., Valenzuela-Almada, M. O., Isnardi, C. A., Quintana, R., Soriano, E. R., Hsu, T. Y. T., D'Silva, K. M., Sparks, J. A., Patel, N. J., Xavier, R. M., Marques, C. D. L., Kakehasi, A. M., Flipo, R. M., Claudepierre, P., Cantagrel, A., Goupille, P., Wallace, Z. S., Bhana, S., Costello, W., Grainger, R., Hausmann, J. S., Liew, J. W., Sirotich, E., Sufka, P., Robinson, P. C., Machado, P. M., Griffiths, C. E. M., Barker, J. N., Smith, C. H., Yazdany, J. & Kappelman, M. D., 1 Oct 2021, In: JAMA Network open. 4, 10, p. e2129639Research output: Contribution to journal › Article › peer-review
Association of Patient Mental Health Status With the Level of Agreement Between Patient and Physician Ratings of Psoriasis Severity
Carr, E., Mahil, S. K., Brailean, A., Dasandi, T., Pink, A. E., Barker, J., Rayner, L., Turner, M., Goldsmith, K. & Smith, C. H., Apr 2021, In: JAMA dermatology. 157, 4, p. 413-420 8 p.Research output: Contribution to journal › Article › peer-review
Defining trajectories of response in patients with psoriasis treated with biologic therapies
the BADBIR Study Group & the PSORT Consortium, Oct 2021, In: British Journal of Dermatology. 185, 4, p. 825-835 11 p.Research output: Contribution to journal › Article › peer-review
Describing the burden of the COVID-19 pandemic in people with psoriasis: findings from a global cross-sectional study
PsoProtect study group, Oct 2021, In: Journal of the European Academy of Dermatology and Venereology : JEADV. 35, 10, p. e636-e640Research output: Contribution to journal › Article › peer-review
DIFFERENCES IN CLINICAL FEATURES AND COMORBID BURDEN BETWEEN HLA-C*06:02 CARRIER GROUPS IN MORE THAN 9,000 PEOPLE WITH PSORIASIS
Douroudis, K., Ramessur, R., Biscaia De Andrade Barbosa, I., Baudry, D., Duckworth, M., Angit, C., Capon, F., Chung, R., Curtis, C., DiMeglio, P., Goudling, J., Griffiths, C., Lee, S., Mahil, S., Parslew, R., Reynolds, N., Shipman, A., warren, R., Yiu, Z. & Simpson, M. & 3 others, Barker, J., Dand, N. & Smith, C., 21 Nov 2021, In: Journal of Investigative Dermatology.Research output: Contribution to journal › Article › peer-review
Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis
Andres Ejarque, R., Ale, H. B. A., Grys, K., Tosi, I., Solanky, S., Ainali, C., Catak, Z., Sreeneebus, H., Saklatvala, J., Dand, N., de Rinaldis, E., Chapman, A., Nestle, F., Barnes, M. R., Richard, W., Reynolds, N. J., Griffiths, C., Barker, J., Smith, C. & Di Meglio, P. & 1 others, COnsortium, P., 6 Aug 2021, In: Nature Communications. 12, 1, p. 4741 1 p., 4741.Research output: Contribution to journal › Article › peer-review
Factors associated with adverse COVID-19 outcomes in patients with psoriasis - insights from a global registry-based study
PsoProtect study group, Jan 2021, In: Journal of Allergy and Clinical Immunology. 147, 1, p. 60-71 12 p.Research output: Contribution to journal › Article › peer-review
Going through a rough patch: oral adverse effects of secukinumab
Yogarajah, S., Mahendran, K., Barker, J., Setterfield, J. & Carey, B., 8 Oct 2021, (E-pub ahead of print) In: Oral Surgery.Research output: Contribution to journal › Article › peer-review
Health Economic Assessment of Optimal Biological Treatment for Moderate-to-Severe Psoriasis
Barker, J., Baker, H., Nadeem, A., Gu, D. H. & Girolomoni, G., 1 Oct 2021, In: CLINICAL DRUG INVESTIGATION. 41, 11, p. 1011-1020 10 p.Research output: Contribution to journal › Article › peer-review
Meeting Report: Psoriasis Stratification to Optimize Relevant Therapy Showcase
PSORT consortium, Aug 2021, In: Journal of Investigative Dermatology. 141, 8, p. 1872-1878 7 p.Research output: Contribution to journal › Comment/debate › peer-review
Risk mitigating behaviours in people with inflammatory skin and joint disease during the COVID-19 pandemic differ by treatment type: a cross-sectional patient survey
Mahil, S. K., Yates, M., Langan, S. M., Yiu, Z. Z. N., Tsakok, T., Dand, N., Mason, K. J., Mcateer, H., Meynell, F., Coker, B., Vincent, A., Urmston, D., Vesty, A., Kelly, J., Lancelot, C., Moorhead, L., Bachelez, H., Bruce, I. N., Capon, F. & Contreras, C. R. & 23 others, Cope, A. P., De la cruz, C., Di Meglio, P., Gisondi, P., Hyrich, K., Jullien, D., Lambert, J., Marzo‐ortega, H., Mcinnes, I., Naldi, L., Norton, S., Puig, L., Sengupta, R., Spuls, P., Torres, T., Warren, R. B., Waweru, H., Weinman, J., Griffiths, C. E. M., Barker, J. N., Brown, M. A., Galloway, J. B. & Smith, C. H., 1 Jul 2021, In: British Journal of Dermatology. 185, 1, p. 80-90Research output: Contribution to journal › Article › peer-review
Risks of basal cell and squamous cell carcinoma in psoriasis patients after treatment with biologic vs non-biologic systemic therapies
the BADBIR Study Group, Aug 2021, In: Journal of the European Academy of Dermatology and Venereology. 35, 8, p. e496-e498Research output: Contribution to journal › Letter › peer-review
A randomised placebo controlled trial of anakinra for treating pustular psoriasis: Statistical analysis plan for stage two of the APRICOT trial
Cro, S., Patel, P., Barker, J., Burden, D. A., Griffiths, C. E. M., Lachmann, H. J., Reynolds, N. J., Warren, R. B., Capon, F., Smith, C. & Cornelius, V., 10 Feb 2020, In: Trials. 21, 1, 158.Research output: Contribution to journal › Review article › peer-review
Association between preadmission frailty and care level at discharge in older adults undergoing emergency laparotomy
on behalf of the ELF Study Group, 1 Feb 2020, In: British Journal of Surgery. 107, 3, p. 218-226 9 p.Research output: Contribution to journal › Article › peer-review
Association of Clinical and Demographic Factors With the Severity of Palmoplantar Pustulosis: Findings from the APRICOT, PLUM and ERASPEN consortia
ERASPEN consortium and the APRICOT and PLUM study team, Nov 2020, In: JAMA dermatology. 156, 11, p. 1216-1222 7 p.Research output: Contribution to journal › Article › peer-review
Clinical characteristics including cardiovascular and metabolic risk factors in adolescents with psoriasis
Blegvad, C., Nybo Andersen, A. M., Groot, J., Zachariae, C., Barker, J. & Skov, L., 1 Jul 2020, In: Journal of The European Academy of Dermatology and Venereology. 34, 7, p. 1516-1523 8 p.Research output: Contribution to journal › Article › peer-review
Clinical Impact of Antibodies against Ustekinumab in Psoriasis: An Observational, Cross-Sectional, Multicenter Study
BADBIR, BSTOP Study Groups & PSORT consortium, Nov 2020, In: Journal of Investigative Dermatology. 140, 11, p. 2129-2137 9 p.Research output: Contribution to journal › Article › peer-review
CYP1A1 enzymatic activity influences skin inflammation via regulation of the AHR pathway
Kyoreva, M., Li, Y., Hoosenally, M., Hardman-Smart, J., Morrison, K., Tosi, I., Tolaini, M., Barinaga, G., Stockinger, B., Mrowietz, U., Nestle, F., Smith, C., Barker, J. & Di Meglio, P., 29 Dec 2020, (E-pub ahead of print) In: Journal of Investigative Dermatology.Research output: Contribution to journal › Article › peer-review
ESDR 2010–2020: Journey toward Translational and Systems Dermatology
Schmuth, M., Biedermann, T., Picardo, M., Florestan, T. & Barker, J., Sept 2020, In: Journal of Investigative Dermatology. 140, 9, p. S167-S170Research output: Contribution to journal › Comment/debate › peer-review
Global reporting of cases of COVID-19 in psoriasis and atopic dermatitis: an opportunity to inform care during a pandemic
The Secure-AD, PsoPROTECT study groups, 1 Aug 2020, In: British Journal of Dermatology. 183, 2, p. 404-406 3 p.Research output: Contribution to journal › Letter › peer-review
IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis
Catapano, M., Vergnano, M., Romano, M., Mahil, S. K., Choon, S.-E., Burden, A. D., Young, H. S., Carr, I. M., Lachmann, H. J., Lombardi, G., Smith, C. H., Ciccarelli, F. D., Barker, J. N. & Capon, F., 1 Apr 2020, In: Journal of Investigative Dermatology. 140, 4, p. 816-826.e3Research output: Contribution to journal › Article › peer-review
Research

Skin Therapy Research Unit
The Skin Therapy Research Unit (STRU) is a dermatology research and clinical trials facility based at St John’s Institute of Dermatology within Guy’s and St Thomas’ NHS Foundation Trust and King’s College, London.
News
Excessive scarring shown to be associated with atopic eczema, hypertension and musculoskeletal diseases
Researchers find that excessive keloid and hypertrophic scarring co-occurs with specific conditions, while ethnicity also plays a part.

Outcomes of psoriasis treatment can be predicted by white blood cell response to test, scientists discover
The way type 2 conventional dendritic cells (cDC2) respond to an in vitro test before the patient commences therapy can predict whether the therapy is going...

Genetic Risk Factors in Childhood Psoriasis
Schwarz, C. W., Blegvad, C., Baudry, D., Tosi, I., Lee, S.-H., Chung, R., Tato-Barcia, E., Curtis, C. J., Smith, C. H., Simpson, M. A., Nybo Andersen, A.-M., Barker, J. N., Di Meglio, P., Skov, L. & Dand, N., 19 Feb 2025, (E-pub ahead of print) In: Journal of Investigative Dermatology.Research output: Contribution to journal › Article › peer-review
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
Dand, N., Stuart, P. E., Bowes, J., Ellinghaus, D., Nititham, J., Saklatvala, J. R., Teder-Laving, M., Thomas, L. F., Traks, T., Uebe, S., Assmann, G., Baudry, D., Behrens, F., Billi, A. C., Brown, M. A., Burkhardt, H., Capon, F., Chung, R., Curtis, C. J. & Duckworth, M. & 30 others, Ellinghaus, E., FitzGerald, O., Gerdes, S., Griffiths, C. E. M., Gulliver, S., Helliwell, P. S., Ho, P., Hoffmann, P., Holmen, O. L., Huang, Z.-M., Hveem, K., Jadon, D., Köhm, M., Kraus, C., Lamacchia, C., Lee, S. H., Ma, F., Mahil, S. K., McHugh, N., McManus, R., Modalsli, E. H., Nissen, M. J., Nöthen, M., Oji, V., Oksenberg, J. R., Patrick, M. T., Smith, C. H., Di Meglio, P., Barker, J. N. & Simpson, M. A., 28 Feb 2025, In: Nature Communications. 16, 1, 1 p., 2051.Research output: Contribution to journal › Article › peer-review
Personalizing Biologic Therapy in Psoriasis: Development, Validation, and User Testing of a Precision-Dosing Dashboard
Thomas, C., Baudry, D., Arkir, Z., Coker, B., Dasandi, T., Powell, K., Arenas-Hernandez, M., Leung, J., Rawstron, K., Nwaogu, C., Chapman, S., Woolf, R., Pink, A. E., Barker, J., Standing, J. F., Smith, C. H. & Mahil, S., 19 Feb 2025, (E-pub ahead of print) In: Journal of Investigative Dermatology.Research output: Contribution to journal › Article › peer-review
Prevalence of comorbidity amongst people with palmoplantar pustulosis: A systematic review and meta-analysis
Gleeson, D., Corbett, M., Choy, S. P., Jiang, T., Lee, J. Y. W., Bechman, K., Russell, M. D., Barker, J. N., Galloway, J. B., Smith, C. H. & Mahil, S. K., 12 May 2025, (Accepted/In press) In: Journal of the European Academy of Dermatology and Venereology.Research output: Contribution to journal › Letter › peer-review
Acceptability of 'as needed' biologic therapy in psoriasis: insights from a multi-stakeholder mixed methods study
Gleeson, D., Naveed, M., Moorhead, L., McAteer, H., Sewell, G., McGuire, A., Weinman, J., Barker, J. N. W. N., Norton, S., Chapman, S. C. E., Smith, C. H. & Mahil, S. K., 1 Aug 2024, In: The British journal of dermatology. 191, 2, p. 243-251 9 p.Research output: Contribution to journal › Article › peer-review
A genome-wide meta-analysis of palmoplantar pustulosis implicates Th2 responses and cigarette smoking in disease pathogenesis
APRICOT and PLUM study team, Sept 2024, In: Journal of Allergy and Clinical Immunology. 154, 3, p. 657-665.e9Research output: Contribution to journal › Article › peer-review
Defining disease severity in atopic dermatitis and psoriasis for the application to biomarker research: an interdisciplinary perspective
Ramessur, R., Dand, N., Langan, S. M., Saklatvala, J., Fritzsche, M.-C., Holland, S., Arents, B. W. M., McAteer, H., Proctor, A., McMahon, D., Greenwood, M., Buyx, A. M., Messer, T., Weiler, N., Hicks, A., Hecht, P., Weidinger, S., Ndlovu, M. N., Chengliang, D. & Hübenthal, M. & 10 others, Egeberg, A., Paternoster, L., Skov, L., De Jong, E. M. G. J., Middelkamp-Hup, M. A., Mahil, S. K., Barker, J. N., Flohr, C., Brown, S. J. & Smith, C. H., 20 Jun 2024, In: The British journal of dermatology. 191, 1, p. 14-23 10 p.Research output: Contribution to journal › Review article › peer-review
Exploring the Link Between Genetic Predictors of Cardiovascular Disease and Psoriasis
Ramessur, R., Saklatvala, J., Budu-Aggrey, A., Ostaszewski, M., Möbus, L., Greco, D., Ndlovu, M., Mahil, S. K., Barker, J. N., Brown, S., Paternoster, L., Dand, N., Simpson, M. A. & Smith, C. H., 18 Sept 2024, In: JAMA Cardiology. 9, 11, p. 1009-1017 9 p.Research output: Contribution to journal › Article › peer-review
International Consensus Definition and Diagnostic Criteria for Generalized Pustular Psoriasis from the International Psoriasis Council
Choon, S. E., Van De Kerkhof, P., Gudjonsson, J. E., De La Cruz, C., Barker, J., Morita, A., Romiti, R., Affandi, A. M., Asawanonda, P., Burden, A. D., Gonzalez, C., Marrakchi, S., Mowla, M. R., Okubo, Y., Oon, H. H., Terui, T., Tsai, T. F., Callis-Duffin, K., Fujita, H. & Jo, S. J. & 14 others, Merola, J., Mrowietz, U., Puig, L., Thaçi, D., Velásquez, M., Augustine, M., El Sayed, M., Navarini, A. A., Pink, A., Prinz, J., Turki, H., Magalhães, R., Capon, F. & Bachelez, H., 17 Jul 2024, In: JAMA dermatology. 160, 7, p. 758-768 11 p.Research output: Contribution to journal › Review article › peer-review
Single-cell analysis of psoriasis resolution demonstrates an inflammatory fibroblast state targeted by IL-23 blockade
Francis, L., McCluskey, D., Ganier, C., Jiang, T., Du-Harpur, X., Gabriel, J., Dhami, P., Kamra, Y., Visvanathan, S., Barker, J., Smith, C. H., Capon, F. & Mahil, S., 30 Jan 2024, In: Nature Communications. 15, 1, 913.Research output: Contribution to journal › Article › peer-review
Are Janus kinase inhibitors an effective treatment for palmoplantar pustulosis? A critically appraised topic
Gleeson, D., Barker, J. N. W. N., Capon, F., Pink, A. E., Woolf, R. T., Smith, C. H. & Mahil, S. K., Apr 2023, In: The British journal of dermatology. 188, 4, p. 471-473 3 p.Research output: Contribution to journal › Article › peer-review
Characteristics of "Super-Responders" and "Super-Non-Responders" to First Biologic Monotherapy for Psoriasis: A Nested Case-control Study
BADBIR Study Group, 11 Nov 2023, (E-pub ahead of print) In: The British journal of dermatology.Research output: Contribution to journal › Article › peer-review
Clinical profile of patients with acute generalized pustular psoriasis with and without IL36RN mutations in multi-ethnic Johor Bahru, Malaysia
Choon, S. E., Tok, P. S. K., Wong, K. W., Lim, Y. T., Nanu, N. M., Barker, J. N. & Capon, F., Aug 2023, In: Experimental Dermatology. 32, 8, p. 1263-1271 9 p.Research output: Contribution to journal › Article › peer-review
Comorbidities of Keloid and Hypertrophic Scars Among Participants in UK Biobank: Comorbidities of excessive scarring
Ung, C. Y., Warwick, A. N., Onoufriadis, A., Barker, J., Parsons, M., McGrath, J., Shaw, T. & Dand, N., 4 Jan 2023, In: JAMA dermatology. 159, 2, p. 172-181 10 p.Research output: Contribution to journal › Article › peer-review
Damaging Alleles Affecting Multiple CARD14 Domains Are Associated with Palmoplantar Pustulosis
The APRICOT and PLUM study team, Mar 2023, In: Journal of Investigative Dermatology. 143, 3, p. 504-508.e5Research output: Contribution to journal › Article › peer-review
Development of antidrug antibodies against adalimumab maps to variation within the HLA-DR peptide-binding groove
Biomarkers of Systemic Treatment Outcomes in Psoriasis (BSTOP) Study Group, Tsakok, T., Saklatvala, J., Rispens, T., Loeff, F. C., de Vries, A., Allen, M. H., Barbosa, I. A., Baudry, D., Dasandi, T., Duckworth, M., Meynell, F., Russell, A., Chapman, A., McBride, S., McKenna, K., Perera, G., Ramsay, H., Ramesh, R. & Sands, K. & 10 others, Shipman, A., Burden, A. D., Griffiths, C. E., Reynolds, N. J., Warren, R. B., Mahil, S., Barker, J., Dand, N., Smith, C. & Simpson, M. A., 22 Feb 2023, In: JCI Insight. 8, 4, e156643.Research output: Contribution to journal › Article › peer-review
Genetic validation of psoriasis phenotyping in UK Biobank supports the utility of self-reported data and composite definitions for large genetic and epidemiological studies
Saklatvala, J. R., Hanscombe, K. B., Mahil, S. K., Tsoi, L. C., Elder, J. T., Barker, J. N., Simpson, M. A., Smith, C. H. & Dand, N., Aug 2023, In: Journal of Investigative Dermatology. 143, 8, p. 1598-1601.e10Research output: Contribution to journal › Letter › peer-review
Manuka honey activates the Aryl Hydrocarbon receptor: implications for skin inflammation
Alangari, A. A., Ashoori, M. D., Alwan, W., Dawe, H., Stockinger, B., Barker, J. N., Wincent, E. & Di Meglio, P., Aug 2023, In: Pharmacological Research. 194, 106848.Research output: Contribution to journal › Article › peer-review
Nonadherence to systemic immune-modifying therapy in people with psoriasis during the COVID-19 pandemic: findings from a global cross-sectional survey
PsoProtect study group, 20 Apr 2023, In: The British journal of dermatology. 188, 5, p. 610-617 8 p.Research output: Contribution to journal › Article › peer-review
Biomarkers of disease progression in people with psoriasis: a scoping review
Ramessur, R., Corbett, M., Marshall, D., Acencio, M., Biscaia De Andrade Barbosa, I., Dand, N., Di Meglio, P., Haddad, S., Jensen, A., Koopmann, W., Mahil, S., Ostaszewski, M., Rahmatulla, S., Rastrick, J., Saklatvala, J., Weidinger, S., Wright, K., Eyerich, K., Ndlovu, M. & Barker, J. & 3 others, Skov, L., Conrad, C. & Smith, C., Oct 2022, In: British Journal of Dermatology. 187, 4, p. 481-493 13 p.Research output: Contribution to journal › Article › peer-review
Biomarkers of systemic treatment response in people with psoriasis: a scoping review
BIOMAP Consortium, Corbett, M., Ramessur, R., Marshall, D., Acencio, M. L., Ostaszewski, M., Barbosa, I. A., Dand, N., Di Meglio, P., Haddad, S., Jensen, A. H. M., Koopmann, W., Mahil, S. K., Rahmatulla, S., Rastrick, J., Saklatvala, J., Weidinger, S., Wright, K., Eyerich, K. & Barker, J. N. & 4 others, Ndlovu, M., Conrad, C., Skov, L. & Smith, C. H., Oct 2022, In: British Journal of Dermatology. 187, 4, p. 494-506 13 p.Research output: Contribution to journal › Article › peer-review
Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling
the BADBIR Study Group & the BSTOP study group, Sept 2022, In: Arthritis and Rheumatology. 74, 9, p. 1535-1543 9 p.Research output: Contribution to journal › Article › peer-review
Differences in Clinical Features and Comorbid Burden between HLA-C∗06:02 Carrier Groups in >9,000 People with Psoriasis
BADBIR & BSTOP Study Groups, Jun 2022, In: Journal of Investigative Dermatology. 142, 6, p. 1617-1628.e10Research output: Contribution to journal › Article › peer-review
Humoral and cellular immunogenicity to a second dose of COVID-19 vaccine BNT162b2 in people receiving methotrexate or targeted immunosuppression: a longitudinal cohort study
Mahil, S. K., Bechman, K., Raharja, A., Domingo-Vila, C., Baudry, D., Brown, M. A., Cope, A. P., Dasandi, T., Graham, C., Khan, H., Lechmere, T., Malim, M. H., Meynell, F., Pollock, E., Sychowska, K., Barker, J. N., Norton, S., Galloway, J. B., Doores, K. J. & Tree, T. & 1 others, Smith, C. H., Jan 2022, In: The Lancet Rheumatology. 4, 1, p. e42-e52Research output: Contribution to journal › Article › peer-review
Influence of FLG loss-of-function mutations in host–microbe interactions during atopic skin inflammation
Oláh, P., Szlávicz, E., Kuchner, M., Nemmer, J., Zeeuwen, P., Lefèvre-Utile, A., Fyhrquist, N., Prast-Nielsen, S., Skoog, T., Serra, A., Rodríguez, E., Raap, U., Meller, S., Gyulai, R., Hupé, P., Kere, J., Levi-Schaffer, F., Tsoka, S., Alexander, H. & Nestle, F. O. & 11 others, Schröder, J. M., Weidinger, S., van den Bogaard, E., Soumelis, V., Greco, D., Barker, J., Lauerma, A., Ranki, A., Andersson, B., Alenius, H. & Homey, B., Jun 2022, In: Journal of Dermatological Science. 106, 3, p. 132-140 9 p.Research output: Contribution to journal › Article › peer-review
Single-cell analysis implicates Th17 to Th2 cell plasticity in the pathogenesis of palmoplantar pustulosis
APRICOT and PLUM study team, Oct 2022, In: Journal of Allergy and Clinical Immunology. 150, 4, p. 882-893 12 p.Research output: Contribution to journal › Article › peer-review
Vaccine hesitancy and access to psoriasis care during the COVID-19 pandemic: findings from a global patient-reported cross-sectional survey
PsoProtect study group, Bechman, K., Cook, E. S., Dand, N., Yiu, Z. Z. N., Tsakok, T., Meynell, F., Coker, B., Vincent, A., Bachelez, H., Barbosa, I., Brown, M. A., Capon, F., Contreras, C. R., De La Cruz, C., Di Meglio, P., Gisondi, P., Jullien, D., Kelly, J. & Lambert, J. & 20 others, Lancelot, C., Langan, S. M., Mason, K. J., McAteer, H., Moorhead, L., Naldi, L., Norton, S., Puig, L., Spuls, P. I., Torres, T., Urmston, D., Vesty, A., Warren, R. B., Waweru, H., Weinman, J., Griffiths, C. M., Barker, J. N., Smith, C. H., Galloway, J. B. & Mahil, S. K., Aug 2022, In: The British journal of dermatology. 187, 2, p. 254-256 3 p.Research output: Contribution to journal › Article › peer-review
Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two-staged, adaptive placebo-controlled trial (APRICOT)
the APRICOT Study Group, 12 Oct 2021, (E-pub ahead of print) In: British Journal of Dermatology.Research output: Contribution to journal › Article › peer-review
Application of information theoretic feature selection and machine learning methods for the development of genetic risk prediction models
BADBIR Study Group & BSTOP study group, Dec 2021, In: Scientific Reports. 11, 1, 23335.Research output: Contribution to journal › Article › peer-review
Association between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death among Patients with Immune-Mediated Inflammatory Disease and COVID-19
Izadi, Z., Brenner, E. J., Mahil, S. K., Dand, N., Yiu, Z. Z. N., Yates, M., Ungaro, R. C., Zhang, X., Agrawal, M., Colombel, J. F., Gianfrancesco, M. A., Hyrich, K. L., Strangfeld, A., Carmona, L., Mateus, E. F., Lawson-Tovey, S., Klingberg, E., Cuomo, G., Caprioli, M. & Cruz-Machado, A. R. & 45 others, Mazeda Pereira, A. C., Hasseli, R., Pfeil, A., Lorenz, H. M., Hoyer, B. F., Trupin, L., Rush, S., Katz, P., Schmajuk, G., Jacobsohn, L., Seet, A. M., Al Emadi, S., Wise, L., Gilbert, E. L., Duarte-García, A., Valenzuela-Almada, M. O., Isnardi, C. A., Quintana, R., Soriano, E. R., Hsu, T. Y. T., D'Silva, K. M., Sparks, J. A., Patel, N. J., Xavier, R. M., Marques, C. D. L., Kakehasi, A. M., Flipo, R. M., Claudepierre, P., Cantagrel, A., Goupille, P., Wallace, Z. S., Bhana, S., Costello, W., Grainger, R., Hausmann, J. S., Liew, J. W., Sirotich, E., Sufka, P., Robinson, P. C., Machado, P. M., Griffiths, C. E. M., Barker, J. N., Smith, C. H., Yazdany, J. & Kappelman, M. D., 1 Oct 2021, In: JAMA Network open. 4, 10, p. e2129639Research output: Contribution to journal › Article › peer-review
Association of Patient Mental Health Status With the Level of Agreement Between Patient and Physician Ratings of Psoriasis Severity
Carr, E., Mahil, S. K., Brailean, A., Dasandi, T., Pink, A. E., Barker, J., Rayner, L., Turner, M., Goldsmith, K. & Smith, C. H., Apr 2021, In: JAMA dermatology. 157, 4, p. 413-420 8 p.Research output: Contribution to journal › Article › peer-review
Defining trajectories of response in patients with psoriasis treated with biologic therapies
the BADBIR Study Group & the PSORT Consortium, Oct 2021, In: British Journal of Dermatology. 185, 4, p. 825-835 11 p.Research output: Contribution to journal › Article › peer-review
Describing the burden of the COVID-19 pandemic in people with psoriasis: findings from a global cross-sectional study
PsoProtect study group, Oct 2021, In: Journal of the European Academy of Dermatology and Venereology : JEADV. 35, 10, p. e636-e640Research output: Contribution to journal › Article › peer-review
DIFFERENCES IN CLINICAL FEATURES AND COMORBID BURDEN BETWEEN HLA-C*06:02 CARRIER GROUPS IN MORE THAN 9,000 PEOPLE WITH PSORIASIS
Douroudis, K., Ramessur, R., Biscaia De Andrade Barbosa, I., Baudry, D., Duckworth, M., Angit, C., Capon, F., Chung, R., Curtis, C., DiMeglio, P., Goudling, J., Griffiths, C., Lee, S., Mahil, S., Parslew, R., Reynolds, N., Shipman, A., warren, R., Yiu, Z. & Simpson, M. & 3 others, Barker, J., Dand, N. & Smith, C., 21 Nov 2021, In: Journal of Investigative Dermatology.Research output: Contribution to journal › Article › peer-review
Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis
Andres Ejarque, R., Ale, H. B. A., Grys, K., Tosi, I., Solanky, S., Ainali, C., Catak, Z., Sreeneebus, H., Saklatvala, J., Dand, N., de Rinaldis, E., Chapman, A., Nestle, F., Barnes, M. R., Richard, W., Reynolds, N. J., Griffiths, C., Barker, J., Smith, C. & Di Meglio, P. & 1 others, COnsortium, P., 6 Aug 2021, In: Nature Communications. 12, 1, p. 4741 1 p., 4741.Research output: Contribution to journal › Article › peer-review
Factors associated with adverse COVID-19 outcomes in patients with psoriasis - insights from a global registry-based study
PsoProtect study group, Jan 2021, In: Journal of Allergy and Clinical Immunology. 147, 1, p. 60-71 12 p.Research output: Contribution to journal › Article › peer-review
Going through a rough patch: oral adverse effects of secukinumab
Yogarajah, S., Mahendran, K., Barker, J., Setterfield, J. & Carey, B., 8 Oct 2021, (E-pub ahead of print) In: Oral Surgery.Research output: Contribution to journal › Article › peer-review
Health Economic Assessment of Optimal Biological Treatment for Moderate-to-Severe Psoriasis
Barker, J., Baker, H., Nadeem, A., Gu, D. H. & Girolomoni, G., 1 Oct 2021, In: CLINICAL DRUG INVESTIGATION. 41, 11, p. 1011-1020 10 p.Research output: Contribution to journal › Article › peer-review
Meeting Report: Psoriasis Stratification to Optimize Relevant Therapy Showcase
PSORT consortium, Aug 2021, In: Journal of Investigative Dermatology. 141, 8, p. 1872-1878 7 p.Research output: Contribution to journal › Comment/debate › peer-review
Risk mitigating behaviours in people with inflammatory skin and joint disease during the COVID-19 pandemic differ by treatment type: a cross-sectional patient survey
Mahil, S. K., Yates, M., Langan, S. M., Yiu, Z. Z. N., Tsakok, T., Dand, N., Mason, K. J., Mcateer, H., Meynell, F., Coker, B., Vincent, A., Urmston, D., Vesty, A., Kelly, J., Lancelot, C., Moorhead, L., Bachelez, H., Bruce, I. N., Capon, F. & Contreras, C. R. & 23 others, Cope, A. P., De la cruz, C., Di Meglio, P., Gisondi, P., Hyrich, K., Jullien, D., Lambert, J., Marzo‐ortega, H., Mcinnes, I., Naldi, L., Norton, S., Puig, L., Sengupta, R., Spuls, P., Torres, T., Warren, R. B., Waweru, H., Weinman, J., Griffiths, C. E. M., Barker, J. N., Brown, M. A., Galloway, J. B. & Smith, C. H., 1 Jul 2021, In: British Journal of Dermatology. 185, 1, p. 80-90Research output: Contribution to journal › Article › peer-review
Risks of basal cell and squamous cell carcinoma in psoriasis patients after treatment with biologic vs non-biologic systemic therapies
the BADBIR Study Group, Aug 2021, In: Journal of the European Academy of Dermatology and Venereology. 35, 8, p. e496-e498Research output: Contribution to journal › Letter › peer-review
A randomised placebo controlled trial of anakinra for treating pustular psoriasis: Statistical analysis plan for stage two of the APRICOT trial
Cro, S., Patel, P., Barker, J., Burden, D. A., Griffiths, C. E. M., Lachmann, H. J., Reynolds, N. J., Warren, R. B., Capon, F., Smith, C. & Cornelius, V., 10 Feb 2020, In: Trials. 21, 1, 158.Research output: Contribution to journal › Review article › peer-review
Association between preadmission frailty and care level at discharge in older adults undergoing emergency laparotomy
on behalf of the ELF Study Group, 1 Feb 2020, In: British Journal of Surgery. 107, 3, p. 218-226 9 p.Research output: Contribution to journal › Article › peer-review
Association of Clinical and Demographic Factors With the Severity of Palmoplantar Pustulosis: Findings from the APRICOT, PLUM and ERASPEN consortia
ERASPEN consortium and the APRICOT and PLUM study team, Nov 2020, In: JAMA dermatology. 156, 11, p. 1216-1222 7 p.Research output: Contribution to journal › Article › peer-review
Clinical characteristics including cardiovascular and metabolic risk factors in adolescents with psoriasis
Blegvad, C., Nybo Andersen, A. M., Groot, J., Zachariae, C., Barker, J. & Skov, L., 1 Jul 2020, In: Journal of The European Academy of Dermatology and Venereology. 34, 7, p. 1516-1523 8 p.Research output: Contribution to journal › Article › peer-review
Clinical Impact of Antibodies against Ustekinumab in Psoriasis: An Observational, Cross-Sectional, Multicenter Study
BADBIR, BSTOP Study Groups & PSORT consortium, Nov 2020, In: Journal of Investigative Dermatology. 140, 11, p. 2129-2137 9 p.Research output: Contribution to journal › Article › peer-review
CYP1A1 enzymatic activity influences skin inflammation via regulation of the AHR pathway
Kyoreva, M., Li, Y., Hoosenally, M., Hardman-Smart, J., Morrison, K., Tosi, I., Tolaini, M., Barinaga, G., Stockinger, B., Mrowietz, U., Nestle, F., Smith, C., Barker, J. & Di Meglio, P., 29 Dec 2020, (E-pub ahead of print) In: Journal of Investigative Dermatology.Research output: Contribution to journal › Article › peer-review
ESDR 2010–2020: Journey toward Translational and Systems Dermatology
Schmuth, M., Biedermann, T., Picardo, M., Florestan, T. & Barker, J., Sept 2020, In: Journal of Investigative Dermatology. 140, 9, p. S167-S170Research output: Contribution to journal › Comment/debate › peer-review
Global reporting of cases of COVID-19 in psoriasis and atopic dermatitis: an opportunity to inform care during a pandemic
The Secure-AD, PsoPROTECT study groups, 1 Aug 2020, In: British Journal of Dermatology. 183, 2, p. 404-406 3 p.Research output: Contribution to journal › Letter › peer-review
IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis
Catapano, M., Vergnano, M., Romano, M., Mahil, S. K., Choon, S.-E., Burden, A. D., Young, H. S., Carr, I. M., Lachmann, H. J., Lombardi, G., Smith, C. H., Ciccarelli, F. D., Barker, J. N. & Capon, F., 1 Apr 2020, In: Journal of Investigative Dermatology. 140, 4, p. 816-826.e3Research output: Contribution to journal › Article › peer-review
Research

Skin Therapy Research Unit
The Skin Therapy Research Unit (STRU) is a dermatology research and clinical trials facility based at St John’s Institute of Dermatology within Guy’s and St Thomas’ NHS Foundation Trust and King’s College, London.
News
Excessive scarring shown to be associated with atopic eczema, hypertension and musculoskeletal diseases
Researchers find that excessive keloid and hypertrophic scarring co-occurs with specific conditions, while ethnicity also plays a part.

Outcomes of psoriasis treatment can be predicted by white blood cell response to test, scientists discover
The way type 2 conventional dendritic cells (cDC2) respond to an in vitro test before the patient commences therapy can predict whether the therapy is going...
