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Julian Naglik

Professor Julian Naglik

Professor in Fungal Pathogenesis & Immunology

Research interests

  • Immunology

Biography

Dr Julian Naglik graduated with a BSc from the University of East London in 1992 and obtained his PhD from King’s College London in 2001, studying the expression of the secreted aspartyl proteinases in the human fungal pathogen Candida albicans. He was appointed Lecturer in 2006, Reader in 2013 and Professor in 2016. Previously, he also undertook roles as a visiting research scientist at the Robert Koch Institute (Berlin, Germany) as well as the University of California San Francisco (USA).

 Julian is currently Professor of Fungal Pathogenesis and Immunology in the Centre for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences at King’s College London. He has made several major scientific, conceptual, and technical advancements including developing in vivo transcript profiling from clinical samples, identifying the epithelial signalling pathways that discriminate between commensal and pathogenic forms of C. albicans, and the recent discovery of candidalysin. Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen and is the essential factor that drives damage and epithelial signalling during C. albicans mucosal infections.

His discovery of candidalysin has been recognised as a seminal advance in microbiology and has transformed the field of Candida pathogenesis. Candidalysin is patented  in the USA and Europe. His research has been supported by the Wellcome Trust, Medical Research Council (MRC), Biotechnology & Biological Sciences Research Council (BBSRC), and National Institutes of Health (NIH). He has been an associate or academic editor for several journals and has received research awards from King's College London, the German Mycological Society, Heinz Maurer-Prize, and the German Society for Hygiene and Microbiology. In 2015, he became an Honorary Member of the British Society of Medical Mycology.

    Research

    Naglik Lab Hero banner
    Naglik Lab

    The Naglik Lab employs molecular, cellular, immunological, biophysical and structural biology to investigate host-fungal interactions.

    pg23-pg-aq-fodocs-gut-microbiome
    Centre for Host-Microbiome Interactions

    Millions of microorganisms live in and on our bodies forming microbiomes on different surfaces. Researchers in the Centre for Host Microbiome Interactions study our relationship with these bacteria and fungi in health or in oral and systemic diseases such as periodontitis, candidiasis, oral cancer and Alzheimer’s disease.

    MBRH-LOGO
    The Multiscale Biofilm Research Hub (MBRH)

    The Multiscale Biofilm Research Hub (MBRH) has been established to promote interdisciplinary interactions and focus microbial biofilm related research at King’s.

    MBRH theme1
    Biofilms at mucosal surfaces

    The study of dental caries, periodontitis, vaginal dysbiosis, chronic inflammatory diseases & infections within the oral cavity, intestinal tract & lungs

    Project status: Ongoing

    News

    Julian Naglik among 65 Fellows elected to the American Academy of Microbiology

    The American Academy of Microbiology (Academy) has elected Professor Julian Naglik and 64 peers to the Class of 2024.

    julian-naglik-news

    A platelet-mediated, beneficial allergic response protects against yeast asthma

    New evidence shows that some allergic reactions provide necessary protection against highly invasive and potentially lethal infectious agents, such as yeast.

    Clys-allergy MODEL

    King's Study Provides Clues to Body's Defense against Common Oral Infection

    An international team, co-led by researchers at King’s College London and the University of Pittsburgh, has identified the mechanism by which the immune...

    mucosal-oral-dry

    Complex mechanism of protection against Candida albicans fungus identified

    King’s scientists identify complex mechanism required for initiating protection against a common fungus.

    Research image

    £2 million award to boost research into fungal infections

    Professor Julian Naglik has been awarded a Wellcome Trust Senior Investigator Award for his work to understand how fungi cause disease.

    Professor Naglik

      Research

      Naglik Lab Hero banner
      Naglik Lab

      The Naglik Lab employs molecular, cellular, immunological, biophysical and structural biology to investigate host-fungal interactions.

      pg23-pg-aq-fodocs-gut-microbiome
      Centre for Host-Microbiome Interactions

      Millions of microorganisms live in and on our bodies forming microbiomes on different surfaces. Researchers in the Centre for Host Microbiome Interactions study our relationship with these bacteria and fungi in health or in oral and systemic diseases such as periodontitis, candidiasis, oral cancer and Alzheimer’s disease.

      MBRH-LOGO
      The Multiscale Biofilm Research Hub (MBRH)

      The Multiscale Biofilm Research Hub (MBRH) has been established to promote interdisciplinary interactions and focus microbial biofilm related research at King’s.

      MBRH theme1
      Biofilms at mucosal surfaces

      The study of dental caries, periodontitis, vaginal dysbiosis, chronic inflammatory diseases & infections within the oral cavity, intestinal tract & lungs

      Project status: Ongoing

      News

      Julian Naglik among 65 Fellows elected to the American Academy of Microbiology

      The American Academy of Microbiology (Academy) has elected Professor Julian Naglik and 64 peers to the Class of 2024.

      julian-naglik-news

      A platelet-mediated, beneficial allergic response protects against yeast asthma

      New evidence shows that some allergic reactions provide necessary protection against highly invasive and potentially lethal infectious agents, such as yeast.

      Clys-allergy MODEL

      King's Study Provides Clues to Body's Defense against Common Oral Infection

      An international team, co-led by researchers at King’s College London and the University of Pittsburgh, has identified the mechanism by which the immune...

      mucosal-oral-dry

      Complex mechanism of protection against Candida albicans fungus identified

      King’s scientists identify complex mechanism required for initiating protection against a common fungus.

      Research image

      £2 million award to boost research into fungal infections

      Professor Julian Naglik has been awarded a Wellcome Trust Senior Investigator Award for his work to understand how fungi cause disease.

      Professor Naglik