Professor Khuloud Al-Jamal Academics Supervisors Professor of Drug Delivery & Nanomedicine and Head of Medicines Development Research subject areas Pharmacology Contact details khuloud.al-jamal@kcl.ac.uk +44 (0) 20 7848 4525
CD47 Knock-Out Using CRISPR-Cas9 RNA Lipid Nanocarriers Results in Reduced Mesenchymal Glioblastoma Growth In Vivo Nanoneedles enable spatiotemporal lipidomics of living tissues Brain distribution study of [14C]-Riluzole following intranasal administration in mice Plasmid DNA ionisable lipid nanoparticles as non-inert carriers and potent immune activators for cancer immunotherapy Cellular uptake and in vivo distribution of mesenchymal-stem-cell-derived extracellular vesicles are protein corona dependent Investigating the Potential of Cuboidal Nanometals as Protein Subunit Vaccine Carriers In Vivo Plasmid DNA cationic non-viral vector complexes induce cytotoxicity-associated PD-L1 expression up-regulation in cancer cells in vitro Combined Facile Synthesis, Purification, and Surface Functionalization Approach Yields Monodispersed Gold Nanorods for Drug Delivery Applications Spatiotemporal tracking of gold nanorods after intranasal administration for brain targeting Intranasal administration of edaravone nanoparticles improves its stability and brain bioavailability The interplay of solvent-drug-protein interactions during albumin nanoparticles formulations for temozolomide delivery to brain cancer cells Serum-derived extracellular vesicles from breast cancer patients contribute to differential regulation of T-cell-mediated immune-escape mechanisms in breast cancer subtypes Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nucleic acid delivery Anti-tumor antibody isotype response can be modified with locally administered immunoadjuvants Lithiated porous silicon nanowires stimulate periodontal regeneration PSMA-targeted NIR probes for image-guided detection of prostate cancer Hyaluronic acid-entecavir conjugates-core/lipid-shell nanohybrids for efficient macrophage uptake and hepatotropic prospects Pre-clinical non-viral vectors exploited for in vivo CRISPR/Cas9 gene editing: an overview Detection of Cancer-Derived Exosomes Using a Sensitive Colorimetric Aptasensor Nucleic acid-based immune checkpoint blockade: Progress and potential Needleless administration of advanced therapies into the skin via the appendages using a hypobaric patch Functionalization of filled radioactive multi-walled carbon nanocapsules by arylation reaction forin vivodelivery of radio-therapy PET Imaging of Small Extracellular Vesicles via [89Zr]Zr(oxinate)4 Direct Radiolabeling Nanomaterial Functionalization Modulates Hard Protein Corona Formation: Atomistic Simulations Applied to Graphitic Materials A natural protein based platform for the delivery of Temozolomide acid to glioma cells Bioengineering of virus-like particles as dynamic nanocarriers for in vivo delivery and targeting to solid tumours Modulating expression of inhibitory and stimulatory immune ‘checkpoints’ using nanoparticulate-assisted nucleic acid delivery Recent progress in nanotechnology-based drug carriers for celastrol delivery Nanoparticle Mediated In Situ Molecular Reprogramming of Immune Checkpoint Interactions for Cancer Immunotherapy Interpreting 2D Materials Bio-Nano Interactions: Influence of Aggregation Status, Protein Corona, Cell Culture Media, and Cell Types An “eat me” combinatory nano-formulation for systemic immunotherapy of solid tumors Comparison between Fluorescence Imaging and Elemental Analysis to Determine Biodistribution of Inorganic Nanoparticles with Strong Light Absorption Tailoring the Architecture of Cationic Polymer Brush-Modified Carbon Nanotubes for Efficient siRNA Delivery in Cancer Immunotherapy Enhanced Delivery of Neuroactive Drugs via Nasal Delivery with a Self-Healing Supramolecular Gel siRNA Design and Delivery Based on Carbon Nanotubes Combinatory Delivery of Etoposide and siCD47 in a Lipid Polymer Hybrid Delays Lung Tumor Growth in an Experimental Melanoma Lung Metastatic Model Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo Accurate large scale modelling of graphene oxide: Ion trapping and chaotropic potential at the interface Green synthesis of methoxy-poly(ethylene glycol)-block-poly(L-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo Defined serum-free three-dimensional culture of umbilical cord-derived mesenchymal stem cells yields exosomes that promote fibroblast proliferation and migration in vitro Development of Real-Time Transendothelial Electrical Resistance Monitoring for an In Vitro Blood-Brain Barrier System A Cyclodextrin‐Stabilized Spermine‐Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment Development of a simple, sensitive and selective colorimetric aptasensor for the detection of cancer-derived exosomes Selective toxicity of functionalised graphene oxide to patients-derived glioblastoma stem cells and minimal toxicity to non-cancerous brain tissue cells Regulatory T Cell Extracellular Vesicles Modify T-Effector Cell Cytokine Production and Protect Against Human Skin Allograft Damage Three-dimensional culture of dental pulp pluripotent-like stem cells (DPPSCs) enhances Nanog expression and provides a serum-free condition for exosome isolation Trichinella spiralis secretes abundant unencapsulated small RNAs with potential effects on host gene expression Design of experiment (DoE)-driven in vitro and in vivo uptake studies of exosomes for pancreatic cancer delivery enabled by copper-free click chemistry-based labelling Optical, electrochemical and electrical (nano)biosensors for detection of exosomes: A comprehensive overview View all publications
16 June 2025 Tens of millions of nanoneedles could replace painful cancer biopsies A patch containing tens of millions of microscopic nanoneedles could soon replace traditional…