Professor Mark Richardson BMBCh, PhD, FRCP

Biography

My lab studies individuals with epilepsy, focussing on one broad question: why do epileptic seizures start? In collaboration with mathematicians and engineers, we construct models of the human brain using a range of imaging and neurophysiological techniques, such as functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), electroencephalography (EEG), simultaneous EEG-fMRI and simultaneous transcranial magnetic stimulation (TMS)-EEG. We aim to understand the underlying mechanisms of seizure onset in terms of such models, comparing healthy people with people who have epilepsy. We also examine how antiepileptic drugs alter brain networks. In addition, we are investigating the long timescale mechanisms of epilepsy, through longterm monitoring of physiological parameters in people with epilepsy, using wearable and implantable sensors. We will use these data to understand why seizures occur at particular times and to forecast seizure onset in real-time.

Please see my Research Staff Profile for more detail.

Find out more about my research:

• Richardson Lab

Key Publications:

• Tangwiriyasakul et al., 2018. Dynamic brain network states in human generalised spike-wave discharges. Brain. 
• Kuhlmann et al., 2018. Seizure prediction: ready for a new era. Nature Reviews Neurology.
• Terry et al., 2012. Seizure generation: The role of nodes and networks. Epilepsia.

View all publications

Key Collaborators:

• Professor John Terry, University of Exeter
• Dr Jonathan O'Muircheartaigh, King's College London
• Professor Dr Andreas Schulze-Bonhage, University of Freiburg
• Dr Ben Brinkmann, Mayo Clinic