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King’s People

Dr Richard Amison

Academics

Lecturer in Pharmacology

Contact details

Biography

Dr Richard Amison is a Lecturer in Pharmacology within the School of Cancer and Pharmaceutical Science and is a member of the Sackler Institute of Pulmonary Pharmacology. After completing his undergraduate studies at Bristol University in 2010, Dr Amison obtained his PhD at King's College London (KCL) in 2014 which included working at the University of Perugia, Italy for 1 year. Dr Amison then continued at KCL in the Sackler Institute of Pulmonary Pharmacology to undertake post-doctoral studies before taking up an academic position in the School of Cancer and Pharmaceutical Science. The research focus of Dr Amison's group is in the understanding of the roles of platelets in the host immune response to bacterial infections. Dr Amison's research contributions have revealed that platelets are critical in the host response to infection not only through the mobilisation of other inflammatory cells but also through direct actions on the bacteria themselves as his research has shown a direct antimicrobial function of platelets. This might therefore offer opportunities for drugs intervention that may be used to 'boost' host defence.

Latest publications

The small quinolone derived compound HT61 enhances the effect of tobramycin against Pseudomonas aeruginosa in vitro and in vivo.
Amison, R. T., Faure, M-E. Y. L., O'Shaughnessy, B. G., Bruce, K., Hu, Y., Coates, A. & Page, C. P., 1 Apr 2020, In : Pulmonary pharmacology & therapeutics. 61, 101884. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.pupt.2019.101884
Pharmacological strategies for targeting platelet activation in asthma
Pitchford, S., Cleary, S., Arkless, K. & Amison, R., 1 Jun 2019, In : Current Opinion in Pharmacology. 46, p. 55-64 10 p. Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1016/j.coph.2019.03.012
LPS-Induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-selectin
Cleary, S. J., Hobbs, C., Amison, R. T., Arnold, S., O'Shaughnessy, B. G., LefranÃ§ais, E., Mallavia, B., Looney, M. R., Page, C. P. & Pitchford, S. C., 1 Aug 2019, In : American Journal of Respiratory Cell and Molecular Biology. 61, 2, p. 232-243 12 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1165/rcmb.2018-0182OC
A dichotomy in platelet activation: Evidence of different functional platelet responses to inflammatory versus haemostatic stimuli
Petito, E., Amison, R. T., Piselli, E., Shah, S., Momi, S., Pitchford, S. C., Gresele, P. & Page, C. P., 25 Oct 2018, In : Thrombosis Research. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.thromres.2018.10.019
Diverse signaling of the platelet P2Y1 receptor leads to a dichotomy in platelet function
Amison, R. T., Jamshidi, S., Rahman, K. M., Page, C. P. & Pitchford, S. C., 11 Mar 2018, In : European Journal of Pharmacology. p. 58-70 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.ejphar.2018.03.014
Platelets Play a Central Role in Sensitization to Allergen
Amison, R. T., Cleary, S. J., Riffo-Vasquez, Y., Bajwa, M., Page, C. P. & Pitchford, S. C., 2018, In : American Journal of Respiratory Cell and Molecular Biology. 59, 1, p. 96-103 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1165/rcmb.2017-0401OC
Platelet Depletion Impairs Host Defence to Pulmonary Infection with Pseudomonas aeruginosa in Mice
Amison, R. T., O'Shaughnessy, B. G., Arnold, S., Cleary, S. J., Nandi, M., Pitchford, S. C., Bragonzi, A. & Page, C. P., Mar 2018, In : American Journal of Respiratory Cell and Molecular Biology. 58, 3, p. 331-340 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1165/rcmb.2017-0083OC
A Non Anti-coagulant Fraction of Heparin Inhibits Leukocyte Diapedesis into the Lung by an Effect on Platelets
Riffo-Vasquez, Y., Somani, A., Man, F., Amison, R., Pitchford, S. & Page, C. P., 1 Oct 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 4, p. 554-563 10 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1165/rcmb.2015-0172OC
P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation
Pan, D., Amison, R. T., Riffo-Vasquez, Y., Spina, D., Cleary, S. J., Wakelam, M. J., Page, C. P., Pitchford, S. C. & Welch, H. C. E., 12 Feb 2015, In : Blood. 125, 7, p. 1146-1158 13 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1182/blood-2014-07-591040
RhoA signaling through platelet P2Y1 receptor controls leukocyte recruitment in allergic mice
Amison, R. T., Momi, S., Morris, A., Manni, G., Keir, S., Gresele, P., Page, C. P. & Pitchford, S. C., Feb 2015, In : Journal of Allergy and Clinical Immunology. 135, 2, p. 528-538.e4 11 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.jaci.2014.09.032

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