Mr Sang-Hyuck Lee

Mr Sang-Hyuck joined NIHR BRC BioResource lab in SGDP in 2013 after completing his MSc in Neuroscience at King's College London. In his role, he has extensively applied his molecular biology skills to process a large number of samples on the high-throughput Illumina genotyping and methylation pipeline. Additionally, he has experience in quality control of raw data, imputation and GWAS analysis, and long-read nanopore sequencing.

He has been involved in the Genetic Links to Anxiety and Depression(GLAD) and Eating Disorders Genetics Initiative(EDGI) studies, where he played a key role in the QC of genotyping data. Since 2022, he has served as the lab manager for NIHR BRC BioResource Laboratory & KCL Genomics. Also, he continues to be involved in cutting-edge research in the field of Eating Disorders as a part-time PhD student at King's College London while also serving as one of the primary analysts in the Psychiatric Consortium Eating Disorder(PGCED) group for the freeze 3 data.

Research interests:

• Genomics
• Proteomics
• Eating Disorders

Key Publications:

• Factors associated with anxiety disorder comorbidity. https://kclpure.kcl.ac.uk/portal/en/publications/factors-associated-with-anxiety-disorder-comorbidity(6be14141-2856-46f3-8145-6b176d798a3b).html 
• Differences in Clinical Features and Comorbid Burden between HLA-C∗06:02 Carrier Groups in >9,000 People with Psoriasis. https://kclpure.kcl.ac.uk/portal/en/publications/differences-in-clinical-features-and-comorbid-burden-between-hlac0602-carrier-groups-in-9000-people-with-psoriasis(338c61e8-1762-4b97-ae4e-43a71a982c63).html 
• The COPILOT Raw Illumina Genotyping QC Protocol. https://kclpure.kcl.ac.uk/portal/en/publications/the-copilot-raw-illumina-genotyping-qc-protocol(74aab7a0-f882-44db-864f-e5a7810a1a4f).html 
• Separate and combined effects of genetic variants and pre-treatment whole blood gene expression on response to exposure-based cognitive behavioural therapy for anxiety disorders. https://kclpure.kcl.ac.uk/portal/en/publications/separate-and-combined-effects-of-genetic-variants-and-pretreatment-whole-blood-gene-expression-on-response-to-exposurebased-cognitive-behavioural-therapy-for-anxiety-disorders(bd6933a5-1a64-427d-b89b-3976bd1e0f65).html
• A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders. https://kclpure.kcl.ac.uk/portal/en/publications/a-genomewide-association-metaanalysis-of-prognostic-outcomes-following-cognitive-behavioural-therapy-in-individuals-with-anxiety-and-depressive-disorders(063476c5-94a2-4b41-9e3c-cc2d6797285f).html
• Inter-individual variation in genes governing human hippocampal progenitor differentiation in vitro is associated with hippocampal volume in adulthood. https://kclpure.kcl.ac.uk/portal/en/publications/interindividual-variation-in-genes-governing-human-hippocampal-progenitor-differentiation-in-vitro-is-associated-with-hippocampal-volume-in-adulthood(efbf9d9c-0cf7-49b2-a70a-5b447fa21858).html
• New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation. https://kclpure.kcl.ac.uk/portal/en/publications/new-insights-on-the-pharmacogenomics-of-antidepressant-response-from-the-gendep-and-stard-studies(07e86c7e-570f-4159-9961-0fd6161fe7ca).html