I studied Biochemistry at the University of Cambridge, followed by a PhD in Protein Design at the Department of Crystallography, Birkbeck College, University of London. Following a postdoctoral fellowship at the Protein Engineering Research Institute in Osaka under the EU scientific training program in Japan, I returned to Cambridge in 1990 as a Zeneca Fellow at the MRC Centre for Protein Engineering to work on protein folding, classification and design.
I co-founded SCOP (the Structural Classification of Proteins database) and developed algorithms to make protein structure predictions and assess their accuracy and to calibrate the reliability of sequence alignment methods. I was one of the most successful participants in the first CASP (Critical Assessment of Structure Prediction) competition in 1994 and a co-organiser of subsequent CASP competitions (CASP2-CASP7) until 2007.
In 1997 I joined the Wellcome Trust Sanger Institute to become Head of Human Genome Analysis, where I was one of the organisers of the sequencing of the human genome. In 1999 I co-founded the Ensembl project to analysis, organise and provide access to the human genome. From 2007 I led the GENCODE project to annotate the structure of all human genes, initially as part of the ENCODE project. I was the Sanger Institute PI of the Genome Reference Consortium, which is responsible for reference genome sequences of human, mouse and zebrafish. I became Head of the Informatics division from 2007. After the announcement of the 100,000 genomes project 2012 I was seconded part-time as a specialist advisor for genomics to NHS England leading up to the creation of Genomics England.
In October 2013 I was appointed Professor of Bioinformatics and Head of the Department of Medical & Molecular Genetics at King's College London and Director of Bioinformatics for King's Health Partners with a part-time secondment as Head of Genome Analysis at Genomics England.
In 2018 I was also appointed as Associate Director (King's) for the Health Data Research London Site.
For a full list of publication please visit the Research Portal.
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