Professor Tim Vyse Professor Tim Vyse Academics Supervisors Professor of Molecular Medicine Research subject areas Biomedical and life sciences Contact details tim.vyse@kcl.ac.uk
Genetics of SLE: does this explain susceptibility and severity across racial groups? Demkova, K., Morris, D. L. & Vyse, T. J., 30 Dec 2022, (E-pub ahead of print) In: Rheumatology. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1093/rheumatology/keac695 Comprehensive genetic and functional analyses of Fc gamma receptors influence on response to rituximab therapy for autoimmunity MATURA Consortia & MASTERPLANS Consortia, Dec 2022, In: EBioMedicine. 86, 104343. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.ebiom.2022.104343 Age acquired skewed X Chromosome Inactivation is associated with adverse health outcomes in humans Roberts, A., Morea, A., Amar, A., Zito, A., El-Sayed Moustafa, J., Tomlinson, M., Bowyer, R., Zhang, X., Christiansen, C., de Oliveira Costeira, R. C., Steves, C., Mangino, M., Bell, J., Wong, C., Vyse, T. & Small, K., 22 Nov 2022, In: eLife. 11 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.7554/eLife.78263 COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection Wang, Y., Guga, S., Wu, K., Khaw, Z., Tzoumkas, K., Tombleson, P., Comeau, M. E., Langefeld, C. D., Cunninghame graham, D. S., Morris, D. L., Vyse, T. J. & Sirugo, G. (ed.), 3 Nov 2022, In: PLoS genetics. 18, 11, p. e1010253 e1010253. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1371/journal.pgen.1010253 Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations Rae, W., Sowerby, J. M., Verhoeven, D., Youssef, M., Kotagiri, P., Savinykh, N., Coomber, E. L., Boneparth, A., Chan, A., Gong, C., Jansen, M. H., du Long, R., Santilli, G., Simeoni, I., Stephens, J., Wu, K., Zinicola, M., Allen, H. L., Baxendale, H., Kumararatne, D., & 17 othersGkrania-Klotsas, E., Scheffler Mendoza, S. C., Yamazaki-Nakashimada, M. A., Ruiz, L. B., Rojas-Maruri, C. M., Lugo Reyes, S. O., Lyons, P. A., Williams, A. P., Hodson, D. J., Bishop, G. A., Thrasher, A. J., Thomas, D. C., Murphy, M. P., Vyse, T. J., Milner, J. D., Kuijpers, T. W. & Smith, K. G. C., 12 Aug 2022, In: Science Immunology. 7, 74, p. eabn3800 eabn3800. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1126/sciimmunol.abn3800 Complement C4, the Major Histocompatibility Complex, and Autoimmunity Vyse, T. J. & Tsao, B. P., Aug 2022, In: Arthritis and Rheumatology. 74, 8, p. 1318-1320 3 p. Research output: Contribution to journal › Editorial › peer-review. DOIs: https://doi.org/10.1002/art.42119 Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups Wang, Y. F., Zhang, Y., Lin, Z., Zhang, H., Wang, T. Y., Cao, Y., Morris, D. L., Sheng, Y., Yin, X., Zhong, S. L., Gu, X., Lei, Y., He, J., Wu, Q., Shen, J. J., Yang, J., Lam, T. H., Lin, J. H., Mai, Z. M., Guo, M., & 15 othersTang, Y., Chen, Y., Song, Q., Ban, B., Mok, C. C., Cui, Y., Lu, L., Shen, N., Sham, P. C., Lau, C. S., Smith, D. K., Vyse, T. J., Zhang, X., Lau, Y. L. & Yang, W., Dec 2021, In: Nature Communications. 12, 1, 772. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41467-021-21049-y Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study Ortiz-Fernández, L., Saruhan-Direskeneli, G., Alibaz-Oner, F., Kaymaz-Tahra, S., Coit, P., Kong, X., Kiprianos, A. P., Maughan, R. T., Aydin, S. Z., Aksu, K., Keser, G., Kamali, S., Inanc, M., Springer, J., Akar, S., Onen, F., Akkoc, N., Khalidi, N. A., Koening, C., Karadag, O., & 51 othersKiraz, S., Forbess, L., Langford, C. A., McAlear, C. A., Ozbalkan, Z., Yavuz, S., Çetin, G. Y., Alpay-Kanitez, N., Chung, S., Ates, A., Karaaslan, Y., McKinnon-Maksimowicz, K., Monach, P. A., Ozer, H. T. E., Seyahi, E., Fresko, I., Cefle, A., Seo, P., Warrington, K. J., Ozturk, M. A., Ytterberg, S. R., Cobankara, V., Onat, A. M., Duzgun, N., Bıcakcıgil, M., Yentür, S. P., Lally, L., Manfredi, A. A., Baldissera, E., Erken, E., Yazici, A., Kısacık, B., Kaşifoğlu, T., Dalkilic, E., Cuthbertson, D., Pagnoux, C., Sreih, A., Reales, G., Wallace, C., Wren, J. D., Cunninghame-Graham, D. S., Vyse, T. J., Sun, Y., Chen, H., Grayson, P. C., Tombetti, E., Jiang, L., Mason, J. C., Merkel, P. A., Direskeneli, H. & Sawalha, A. H., 7 Jan 2021, In: American Journal of Human Genetics. 108, 1, p. 84-99 16 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.ajhg.2020.11.014 Major histocompatibility complex and SLE Fernando, M. M. A. & Vyse, T. J., 1 Jan 2021, Lahita’s Systemic Lupus Erythematosus. Elsevier, p. 5-24 20 p. Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review. DOIs: https://doi.org/10.1016/B978-0-12-820583-9.00020-8 Nucleolin acts as the receptor for C1QTNF4 and supports C1QTNF4-mediated innate immunity modulation Vester, S. K., Beavil, R. L., Lynham, S., Beavil, A. J., Cunninghame Graham, D. S., McDonnell, J. M. & Vyse, T. J., 1 Jan 2021, In: Journal of Biological Chemistry. 296, 100513. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.jbc.2021.100513 View all publications