Professor Toby Lawrence Academics Professor of Inflammation Biology Contact details toby.lawrence@kcl.ac.uk +44 (0) 20 7848 8630
Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer Etzerodt, A., Moulin, M., Doktor, T. K., Delfini, M., Mossadegh-Keller, N., Bajenoff, M., Sieweke, M. H., Moestrup, S. K., Auphan-Anezin, N. & Lawrence, T., 6 Apr 2020, In : The Journal of experimental medicine. 217, 4, e20191869. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1084/jem.20191869 Targeting stat3 and stat5 in tumor-associated immune cells to improve immunotherapy Verdeil, G., Lawrence, T., Schmitt-Verhulst, A. M. & Auphan-Anezin, N., 1 Dec 2019, In : Cancers. 11, 12, 1832. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.3390/cancers11121832 Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression Etzerodt, A., Tsalkitzi, K., Maniecki, M., Damsky, W., Delfini, M., Baudoin, E., Moulin, M., Bosenberg, M., Graversen, J. H., Auphan-Anezin, N., Moestrup, S. K. & Lawrence, T., 7 Oct 2019, In : The Journal of experimental medicine. 216, 10, p. 2394-2411 18 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1084/jem.20182124 Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression Goossens, P., Rodriguez-Vita, J., Etzerodt, A., Masse, M., Rastoin, O., Gouirand, V., Ulas, T., Papantonopoulou, O., Van Eck, M., Auphan-Anezin, N., Bebien, M., Verthuy, C., Vu Manh, T. P., Turner, M., Dalod, M., Schultze, J. L. & Lawrence, T., 4 Jun 2019, In : CELL METABOLISM. 29, 6, p. 1376-1389.e4 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.cmet.2019.02.016 Precise and rapid validation of candidate gene by allele specific knockout with CRISPR/Cas9 in wild mice Chao, T., Liu, Z., Zhang, Y., Zhang, L., Huang, R., He, L., Gu, Y., Chen, Z., Zheng, Q., Shi, L., Zheng, W., Qi, X., Kong, E., Zhang, Z., Lawrence, T., Liang, Y. & Lu, L., 1 Jan 2019, In : Frontiers in Genetics. 10, FEB, 124. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.3389/fgene.2019.00124 The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis Huang, R., Guo, G., Lu, L., Fu, R., Luo, J., Liu, Z., Gu, Y., Yang, W., Zheng, Q., Chao, T., He, L., Wang, Y., Niu, Z., Wang, H., Lawrence, T., Malissen, M., Malissen, B., Liang, Y. & Zhang, L., 1 Jan 2019, In : Journal of Lipid Research. 60, 12, p. 2006-2019 14 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1194/jlr.M094771 Autophagy in dendritic cells Ghislat, G. & Lawrence, T., 26 Mar 2018, In : Cellular Immunology. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/cmi.2018.2 GADD45β Loss Ablates Innate Immunosuppression in Cancer Verzella, D., Bennett, J., Fischietti, M., Thotakura, A. K., Recordati, C., Pasqualini, F., Capece, D., Vecchiotti, D., D'Andrea, D., Di Francesco, B., De Maglie, M., Begalli, F., Tornatore, L., Papa, S., Lawrence, T., Forbes, S. J., Sica, A., Alesse, E., Zazzeroni, F. & Franzoso, G., Mar 2018, In : Cancer Research. 78, 5, p. 1275-1292 18 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1158/0008-5472.CAN-17-1833 Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone Habbeddine, M., Verthuy, C., Rastoin, O., Chasson, L., Bebien, M., Bajenoff, M., Adriouch, S., den Haan, J. M. M., Penninger, J. M. & Lawrence, T., 28 Nov 2017, In : Cell Reports. 21, 9, p. 2515-2527 13 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.celrep.2017.10.111 The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation Lee, C. Y., Lai, T. Y., Tsai, M. K., Chang, Y. C., Ho, Y. H., Yu, I. S., Yeh, T. W., Chou, C. C., Lin, Y. S., Lawrence, T. & Hsu, L. C., 8 Jun 2017, In : Nat Commun. 8, 15502. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/ncomms15502 View all publications
17 January 2020 Unique cells identified could lead to potential ovarian cancer treatment Researchers have identified a unique subset of cells that contribute to the spread of ovarian cancer…