My lab aims to understand the biology of gamma-delta T cells in human tissues and cancers. These cells are seeded perinatally and developmentally into steady-state tissues without obvious inflammatory triggers. Whilst they can readily mount local and rapid responses to cancer, their presence at steady state suggests a nuanced role which balances self-tolerance versus tumour-rejection. In juxtaposition, effective and manageable cancer immunotherapy is fundamentally a balance of tolerance versus rejection. Thus, tissue-resident gamma-delta T cells would seem critical to cancer immunosurveillance as they straddle this dichotomy, yet they remain understudied in human health and disease.

Publications:

• ORCID
• Google Scholar Pages

Key publications (most recent first):

• Clinical and experimental treatment of advanced melanoma with a focus on immunotherapy
• PD-1 defines a distinct, functional, tissue-adapted state in Vδ1⁺ T cells with implications for cancer immunotherapy
• Local γδ T cells: translating promise to practice in cancer immunotherapy
• Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19
• A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer
• An innate-like Vδ1⁺ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer
• Human γδ T Cells: A Lymphoid Lineage Cell Capable of Professional Phagocytosis