Postdoctoral Research Associate
Lecturer in Nanomaterials and Biointerfaces
Postdoctoral Research Associate
Tissue Engineering
Engineering tissues ultimately rely on precisely guiding the fate of cells in vivo to recapitulate architecture and function. In fact a great share of the present limitations of regenerative medicine amount to our inability to accurately and precisely manipulate cells in vivo to determine their fate.
We are developing nanotechnology approaches to precisely control cell behaviour in vivo with high space and time resolution.
Our first step was developing a strategy for localised, minimally invasive in vivo intracellular delivery of genes, which led to the engineering of new blood vessels in the muscle of mouse.
Nature article on Tissue Engineering
Precision Medicine
Precision medicine aims to provide the optimal treatment for each patient through an improved understanding of the molecular profile of the condition affecting each individual. Equipped with a patient’s molecular profile doctors can determine the best treatment option.
We are developing a novel nanotechnology platform to provide rapid, minimally invasive and reliable molecular profiling of diseases, to overcome current shortcomings that limit the clinical adoption of precision medicine.
Our first step was developing a biomarker-based approach to map tumour marker activity in cell cultures and across the margin area of tissue with a resolution approaching that of a single cell, and with high sensitivity and specificity.
Advanced Materials article on Precision Medicine
Biointerface
The molecular interactions that control cell fate occur at the nanoscale and nanomaterials can be engineered to modulate the biochemical and biophysical signals presented at those lenghtscales in space and time.
We are developing a set of platforms and tools to study the interaction of nanomaterials with subcellular components, in order to engineer functional biointerfaces.
Our first step was investigating the biointerface of silicon nanoneedles to elucidate the mechanisms of intracellular delivery of nanoparticles in vitro and in vivo.
Advanced Materials article on Biointerface
Publications from the Chiappini Lab
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Martella, D. A., Okesola, M. & Chiappini, C., 1 Jan 2018, Handbook of Nanomaterials for Cancer Theranostics. Elsevier, p. 421-462 42 p. Research output: Chapter in Book/Report/Conference proceeding - Chapter. DOIs: https://doi.org/10.1016/B978-0-12-813339-2.00014-1
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Decuzzi, P., Coclite, A., Lee, A., Palange, A. L., Di Mascolo, D., Chiappini, C., Santos, H. A., Coluccio, M. L., Perozziello, G., Candeloro, P., Di Fabrizio, E. & Gentile, F., 1 Jan 2017, Springer Handbooks. SPRINGER, p. 643-691 49 p. (Springer Handbooks). Research output: Chapter in Book/Report/Conference proceeding - Chapter. DOIs: https://doi.org/10.1007/978-3-662-54357-3_21
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Gopal, S., Chiappini, C., Armstrong, J. P. K., Chen, Q., Serio, A., Hsu, C. C., Meinert, C., Klein, T. J., Hutmacher, D. W., Rothery, S. & Stevens, M. M., 6 Aug 2019, In : Advanced Materials. 31, 32, 1900488. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1002/adma.201900488
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Hansel, C. S., Crowder, S. W., Cooper, S., Gopal, S., João Pardelha Da Cruz, M., De Oliveira Martins, L., Keller, D., Rothery, S., Becce, M., Cass, A. E. G., Bakal, C., Chiappini, C. & Stevens, M. M., 26 Mar 2019, In : ACS Nano. 13, 3, p. 2913-2926 14 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1021/acsnano.8b06998
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Onesto, V., Barrell, W. B., Okesola, M., Amato, F., Gentile, F., Liu, K. J. & Chiappini, C., 1 Jun 2019, In : BIOMEDICAL MICRODEVICES. 21, 2, 10 p., 44. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1007/s10544-019-0390-0
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Gopal, S., Chiappini, C., Penders, J., Leonardo, V., Seong, H., Rothery, S., Korchev, Y., Shevchuk, A. & Stevens, M. M., 22 Mar 2019, In : Advanced Materials. 31, 12, 1806788. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1002/adma.201806788
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Zijl, S., Vasilevich, A. S., Viswanathan, P., Helling, A. L., Beijer, N. R. M., Walko, G., Chiappini, C., de Boer, J. & Watt, F. M., 15 Jan 2019, In : Acta Biomaterialia. 84, p. 133-145 13 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.actbio.2018.12.003
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Chiappini, C., 4 Jul 2018, Handbook of Porous Silicon: Second Edition. Springer International Publishing Switzerland, Vol. 1-2. p. 247-267 21 p. Research output: Chapter in Book/Report/Conference proceeding - Chapter. DOIs: https://doi.org/10.1007/978-3-319-71381-6_17
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Chiappini, C., 4 Jul 2018, Handbook of Porous Silicon: Second Edition. Springer International Publishing Switzerland, Vol. 1-2. p. 185-201 17 p. Research output: Chapter in Book/Report/Conference proceeding - Chapter. DOIs: https://doi.org/10.1007/978-3-319-71381-6_134
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Bergholt, M. S., Serio, A., McKenzie, J. S., Boyd, A., Soares, R. F., Tillner, J., Chiappini, C., Wu, V., Dannhorn, A., Takats, Z., Williams, A. & Stevens, M. M., 24 Jan 2018, In : ACS Central Science. 4, 1, p. 39-51 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1021/acscentsci.7b00367
- King’s Together EPSRC Capital Equipment Award for Early Career Researchers (2019)
- ERC Starting Grant (2018-2023)
- KHP R&D Challenge Fund (2018-2019)
- NC3R Project Grant (2018-2019)
- Royal Society International Exchange (2018-2019)
- British Council Israeli Fellowship (2018)
- Rosetrees Trust PhD Studentship (2017 –2020).