The Cobb Group has been involved in the development of asymmetric methodologies towards biologically inspired molecules since 2005. They have pioneered the synthesis of unnatural amino acids, mono and diterpenes (such as the cannabinoids), steroids, alkaloids and nucleoside frameworks – generally all using organocatalytic approaches. They have also applied many of these targets towards purposes such as the design of antivirals, anticonvulsants, lipids, and cardiac medications. In particular, they have used unnatural amino acids within unnatural peptides with highly defined secondary structures (so-called foldamers) that themselves can be applied to catalysis or peptidomimetics (with an example target being an enzyme of SARS-CoV-2). The Cobb Group has also developed a range of bifunctional probes for the detection of protein movement in real time. They also collaborate with many other groups both national and international.
The Cobb Group is very well-equipped for synthetic methodology, with a chiral phase HPLC, an automated chromatography unit, ozonizer, cryocooler, and polarimeter in addition to the usual synthetic organic chemistry furnishings (stirrer hotplates, rotavaps etc). Funding has been obtained from EPSRC, BBSRC, MRC, CR-UK, the Leverhulme Trust, the Royal Society and Industry (e.g. Syngenta, GW Pharmaceuticals) amongst others.
Please also see the Cobb Group website for more information.
Themes
Asymmetric Methodology
Development of new stereoselective routes to highly functionalised molecules.
Foldamer Research
Design and synthesis of novel peptide inspired oligomers that fold into unique and useful molecular architectures.
Chemical Biology
Synthesis of probes that will give us a better understanding of protein dynamics in situ.
Publications
Awards
Thieme Chemistry Journals Award
Faculty Research Output Prize
News
King's chemists develop revolutionary new approach to designing catalysts for chemical reactions
This breakthrough will enable scientists to more carefully control and guide reactions.

Themes
Asymmetric Methodology
Development of new stereoselective routes to highly functionalised molecules.
Foldamer Research
Design and synthesis of novel peptide inspired oligomers that fold into unique and useful molecular architectures.
Chemical Biology
Synthesis of probes that will give us a better understanding of protein dynamics in situ.
Publications
Awards
Thieme Chemistry Journals Award
Faculty Research Output Prize
News
King's chemists develop revolutionary new approach to designing catalysts for chemical reactions
This breakthrough will enable scientists to more carefully control and guide reactions.

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