Skip to main content
Back to King's College London homepage

The Cobb Group has been involved in the development of asymmetric methodologies towards biologically inspired molecules since 2005. They have pioneered the synthesis of unnatural amino acids, mono and diterpenes (such as the cannabinoids), steroids, alkaloids and nucleoside frameworks – generally all using organocatalytic approaches. They have also applied many of these targets towards purposes such as the design of antivirals, anticonvulsants, lipids, and cardiac medications. In particular, they have used unnatural amino acids within unnatural peptides with highly defined secondary structures (so-called foldamers) that themselves can be applied to catalysis or peptidomimetics (with an example target being an enzyme of SARS-CoV-2). The Cobb Group has also developed a range of bifunctional probes for the detection of protein movement in real time. They also collaborate with many other groups both national and international.

The Cobb Group is very well-equipped for synthetic methodology, with a chiral phase HPLC, an automated chromatography unit, ozonizer, cryocooler, and polarimeter in addition to the usual synthetic organic chemistry furnishings (stirrer hotplates, rotavaps etc). Funding has been obtained from EPSRC, BBSRC, MRC, CR-UK, the Leverhulme Trust, the Royal Society and Industry (e.g. Syngenta, GW Pharmaceuticals) amongst others.

Please also see the Cobb Group website for more information.  

People

PhD Student

PhD Student

PhD Student

PhD Candidate

Themes

Asymmetric methodology
Asymmetric Methodology

Development of new stereoselective routes to highly functionalised molecules.

    Foldamer
    Foldamer Research

    Design and synthesis of novel peptide inspired oligomers that fold into unique and useful molecular architectures.

      Chem bio image
      Chemical Biology

      Synthesis of probes that will give us a better understanding of protein dynamics in situ.

        Publications

          Awards

          Thieme Chemistry Journals Award

          Faculty Research Output Prize

          News

          King's chemists develop revolutionary new approach to designing catalysts for chemical reactions

          This breakthrough will enable scientists to more carefully control and guide reactions.

          Helix

          People

          PhD Student

          PhD Student

          PhD Student

          PhD Candidate

          Themes

          Asymmetric methodology
          Asymmetric Methodology

          Development of new stereoselective routes to highly functionalised molecules.

            Foldamer
            Foldamer Research

            Design and synthesis of novel peptide inspired oligomers that fold into unique and useful molecular architectures.

              Chem bio image
              Chemical Biology

              Synthesis of probes that will give us a better understanding of protein dynamics in situ.

                Publications

                  Awards

                  Thieme Chemistry Journals Award

                  Faculty Research Output Prize

                  News

                  King's chemists develop revolutionary new approach to designing catalysts for chemical reactions

                  This breakthrough will enable scientists to more carefully control and guide reactions.

                  Helix

                  Our Partners

                  BBSRC

                  Biotechnology & Biological Sciences Research Council

                  The Engineering and Physical Sciences Research Council

                  The Engineering and Physical Sciences Research Council (EPSRC)

                  Group lead