700 MHz NMR Spectrometer

The 700 MHz NMR spectrometer is composed of a 16.4 T superconducting magnet, a quadruple resonance (1H/13C/15N/31P) cryoprobe with z-gradients, and a Bruker Avance III console. It is equipped with a SampleJet accessory capable of handling high sample volumes- up to 49 individual tubes and five 96-well plates with tubes of >5 mm diameter, making it well-suited for automated, medium-throughput applications such as fragment-based screening and metabolomics.

This high-field instrument supports a wide range of modern, multi-dimensional NMR experiments for structural biology, including those involving 13C, 15N, and 31P nuclei, thus enabling advanced studies of nucleic acids as well as proteins.

Recently, a broadband observe (BBO) probe was added to the system, further expanding the spectrometer’s capabilities by allowing experiments on a broader range of NMR-active nuclei beyond the standard biomolecular set. This opens up new possibilities for researchers working with non-traditional nuclei in inorganic, organometallic, or small molecule systems.