A flexible high‑field system for structural biology, small‑molecule research and automated workflows

Key features

• 16.4 T superconducting magnet
• Bruker Avance III console
• 1H/13C/15N/31P QCI helium‑cooled cryoprobe with z‑gradients
• Broadband observe (BBO) probe
• SampleJet automated sample changer

The 700 MHz NMR spectrometer comprises a 16.4 T superconducting magnet, a quadruple‑resonance 1H/13C/15N/31P QCI helium‑cooled cryoprobe with z‑gradients, and a Bruker Avance III console. The system is equipped with a SampleJet automated sample changer capable of handling high sample volumes, supporting up to 49 individual tubes and five 96‑well racks with samples of up to 5 mm diameter. This configuration makes the instrument well suited to automated, medium‑throughput workflows, including fragment‑based screening and metabolomics.

This high‑field system supports a broad range of modern multidimensional solution‑state NMR experiments for structural biology. The QCI cryoprobe enables advanced studies of proteins, RNA, DNA and protein–nucleic acid complexes using C-13, N-15 and P-31 nuclei, facilitating detailed investigations of biomolecular structure, dynamics and interactions.

More recently, a broadband observe (BBO) probe has been added to the system, further expanding its capabilities beyond biomolecular NMR. The BBO probe enables experiments on a wide range of less commonly studied NMR‑active nuclei, supporting chemically diverse research in small‑molecule, inorganic and organometallic systems.