The SEISMIC facility houses several items of equipment that can be used to isolate single cells or even sub-cellular compartments under microscope observation. We can provide analysis of the isolated material using mass spectrometry.

Our facility houses a recently commercialised single-cell sampling system from Yokogawa Corporation (see the details of the SS2000  for further information). The technology enables single, live cells or their sub-cellular components to be extracted into a capillary under microscope observation. We can use fluorescence to visualise specific constituents of a cell or expression of particular markers (e.g. mitochondria, nucleus, lipid droplets, GFP-labelled proteins). The extracted cell material can be eluted into plates, surfaces or vials for downstream analysis, e.g. mass spectrometry, transcriptomics etc.

We can provide mass spectrometry analysis for drugs, metabolites and lipids, and we have established collaborations to detect other analytes (e.g. proteins, transcripts). We have a pump priming scheme, which can be used to gain proof of concept data for funding applications. This service will be free to BBSRC researchers until 2026.

You can download our access form - please get in touch to discuss with us your requirements with us so we can help you to design your experiments. You can download our sample requirements here.