The Single Cellome™ System 2000 is a system that automatically samples specific regions of cells or whole cells at the single-cell level while imaging cells in culture with a confocal microscope. Because cells in culture do not need to be detached, positional and morphological information is maintained.

Sampling features

• Automated operation.
• Precise pipetting control of location works.
• Sampling with location and morphology information.
• High resolution images and image analysis using confocal microscopy.
• Incubator function for maintaining cell activity.

Use Cases

1. Intracellular components can be sampled at a single-cell level. This includes intracellular components that are difficult to sample by biochemical methods, such as organelles without lipid membranes.
2. By sampling while maintaining the positional information, it is possible to sample and analyze the normal cells adjacent to the cancer cells and the normal cells located away from the cancer cells.
3. Sampling is possible while maintaining morphological information. Allowing cells with different morphological changes can be sampled and compared.
4. Different parts of a neuron, such as a cell body or axon, can be targeted for sampling.
5. Single-cell cloning is possible from specific cells or cells with specific behavior under microscopic observation, such as transfected cells or virus-resistant cells. By combining various image analysis techniques, accurate and efficient cloning is possible.
6. Multiple samples can be collected in the same well for analysis that requires a sample volume.