Interferon-mediated responses to Infection by Flaviviruses

This project aims to identify and mechanistically characterise Interferon-stimulated genes (ISGs) that inhibit the replication of Flavivirus such as Dengue and Zika viruses. Furthermore, we intend to uncover strategies explored by this virus family to circumvent host innate immunity, with a particular focus on the potential role played by conserved sfRNA-associated RNA structures within flavivirus RNA genomes. Finally, we will address the potential for these sfRNA structures to act as molecular targets for antiviral agents.