At the Genetic Variation & Synthetic Function Group, we explore how changes in our DNA influence gene function and contribute to human disease. By combining cutting-edge genomics, computational biology, and deep-mutational scanning experiments, we aim to uncover the molecular mechanisms behind genetic variation and use that knowledge to engineer new biological systems for therapeutic innovation.

Our research focuses on key regulators such as transcription factors and RNA editing enzymes, using high-throughput experimental data to map their functional impacts at scale. Through this work, we strive to bridge discovery science with real-world biomedical applications.