P-21 activated kinase (PAK) interactome in cancer Our work is focused on understanding how cancer cells are able to migrate and invade through tissues. We have been investigating the PAK family proteins in this context. This work includes both study of PAK1-6 and the signalling nexus that surrounds these proteins including RhoU and PDZRhoGEF. These studies include both 2D, 3D and in vivo invasion assays, with a special interest in the activity of invadopodia in this process. Work in this area spans breast, prostate, oesophageal and ovarian cancer, as well as melanoma studies.