Our research Our work focuses mainly on immune cells but also extends to study cancer metastasis as adhesion also plays a role there. Similarly, to above described adhesion defects, if cells from solid tumours lose their contact inhibition, start to detach from each other and migrate to secondary sites (metastasis formation) this severely diminishes the chance of a good prognosis for a patient suffering from cancer, highlighting the importance of the precise temporal and spatial control of these pathways. Despite their importance, these pathways are still not well understood. Our aims, therefore, are to uncover and study novel regulators of cell adhesion and migration, especially in relation to integrin receptors; to elucidate which pathways are co-ordinately regulated; and to define how and when these pathways get triggered; to describe how their dysregulation affects human health; and ultimately whether they can be targeted for therapeutic intervention. We are addressing these questions by using a combination of molecular and cell biological approaches, including CRISPR technology, Mass Spectroscopy, next-generation sequencing, and mouse genetics.