The role of Irregular connective tissue in soft tissue patterning, repair and homeostasis Diseases that disrupt musculoskeletal (MSK) system function are common and place a significant burden on affected individuals and their carers. Nationally, they cause significant healthcare costs and lost productivity. Many diseases affecting skeletal muscle have their origins in the failure of normal muscle formation or failure of muscle repair. The importance of the irregular connective tissue (ICT) that surrounds muscle cells in building and maintaining skeletal muscle tissue has been clearly demonstrated. However, very little is known about how ICT acts during muscle formation and repair. Harnessing the activities of this cell population is an essential component in strategies to engineer muscle tissue Our objectives are to learn what ICT is doing during muscle formation, how this has become disrupted to cause muscle hypoplasia/dysplasia and how to harness the activities of ICT for regenerative strategies.