Lymphoma Immunology

The Lymphoma Immunology research group is led by Dr Alan G. Ramsay, Senior PI/Associate Professor at King's College London. His work has characterised tumour cell-induced T cell immune evasion mechanisms in chronic lymphocytic leukaemia (CLL) and lymphoma and translated bench science to clinical trials with immunotherapy. The current projects of the group are focused on modelling and studying tumour microenvironment (TME) stromal cells to gain knowledge for optimising future immunotherapy-based treatments for patients.

The Lymphoma Immunology group is based at Guy’s Cancer Centre, London Bridge.

Members

Vitoria Meyer Cantinho Pereira

PhD Student

Alan Ramsay

Reader (Associate Professor) in Lymphoma Biology

Identifying effective combination immunotherapy and mechanisms of action (MOA) within the lymphoma tumour microenvironment (TME)

Studying the immunobiology of fibroblasts within lymphoid tissue TMEs

Clinical trial-associated correlative science to identify bio-assays/-markers for developing future personalised medicine

Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter's Trans-Formed DLBCL and Germinal Center B-Cells
Uhl, B., Prochazka, K. T., Pansy, K., Wenzl, K., Strobl, J., Baumgartner, C., Szmyra, M. M., Waha, J. E., Wolf, A., Tomazic, P. V., Steinbauer, E., Steinwender, M., Friedl, S., Weniger, M., Küppers, R., Pichler, M., Greinix, H. T., Stary, G., Ramsay, A. G., Apollonio, B. & 4 others, Feichtinger, J., Beham-Schmid, C., Neumeister, P. & Deutsch, A. J., 17 Jul 2022, In: International Journal of Molecular Sciences. 23, 14, 7874. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3390/ijms23147874
Activation and expansion of T-follicular helper cells in chronic lymphocytic leukemia nurselike cell co-cultures
Vaca, A. M., Ioannou, N., Sivina, M., Vlachonikola, E., Clise-Dwyer, K., Kim, E., Li, D., Ma, Q., Ferrajoli, A., Estrov, Z., Wierda, W. G., Patten, P. E. M., Ramsay, A. G. & Burger, J. A., May 2022, In: Leukemia. 36, 5, p. 1324-1335 12 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41375-022-01519-y
Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity
Hanna, B. S., Llaó-Cid, L., Iskar, M., Roessner, P. M., Klett, L. C., Wong, J. K. L., Paul, Y., Ioannou, N., Öztürk, S., Mack, N., Kalter, V., Colomer, D., Campo, E., Bloehdorn, J., Stilgenbauer, S., Dietrich, S., Schmidt, M., Gabriel, R., Rippe, K., Feuerer, M. & 4 others, Ramsay, A. G., Lichter, P., Zapatka, M. & Seiffert, M., 14 Dec 2021, In: Immunity. 54, 12, p. 2825-2841.e10 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.immuni.2021.11.004
Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma
Graham, C. E., Jozwik, A., Quartey-Papafio, R., Ioannou, N., Metelo, A. M., Scala, C., Dickson, G., Stewart, O., Almena-Carrasco, M., Peranzoni, E., Ramsay, A. G., Patten, P. E. M., Pertel, T., Farzaneh, F., Dupouy, S., Pepper, A. & Benjamin, R., Dec 2021, In: Leukemia. 35, 12, p. 3581-3584 4 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41375-021-01324-z
Targeting the tumor microenvironment in chronic lymphocytic leukemia
Svanberg, R., Janum, S., Patten, P. E. M., Ramsay, A. G. & Niemann, C. U., Sep 2021, In: Haematologica. 106, 9, p. 2312-2324 13 p. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.3324/haematol.2020.268037
Immunomodulatory drugs for the treatment of b cell malignancies
Ioannou, N., Jain, K. & Ramsay, A. G., 2 Aug 2021, In: International Journal of Molecular Sciences. 22, 16, 8572. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.3390/ijms22168572
ImmunoCluster provides a computational framework for the non-specialist to profile high- dimensional cytometry data
Opzoomer, J. W., Timms, J. A., Blighe, K., Mourikis, T. P., Chapuis, N., Bekoe, R., Kareemaghay, S., Nocerino, P., Apollonio, B., Ramsay, A. G., Tavassoli, M., Harrison, C., Ciccarelli, F. D., Parker, P., Fontenay, M., Barber, P. R., Arnold, J. N. & Kordasti, S., Apr 2021, In: eLife. 10, e62915. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.7554/eLife.62915
Understanding the Immune-Stroma Microenvironment in B Cell Malignancies for Effective Immunotherapy
Apollonio, B., Ioannou, N., Papazoglou, D. & Ramsay, A. G., 25 Mar 2021, In: Frontiers in oncology. 11, 626818. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.3389/fonc.2021.626818
A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice
Patten, P. E. M., Ferrer, G., Chen, S. S., Kolitz, J. E., Rai, K. R., Allen, S. L., Barrientos, J. C., Ioannou, N., Ramsay, A. G. & Chiorazzi, N., 9 Mar 2021, In: Frontiers in Immunology. 12, 627020. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2021.627020
Triggering interferon signaling in T cells with avadomide sensitizes CLL to anti-PD-L1/PD-1 immunotherapy
Ioannou, N., Hagner, P. R., Stokes, M., Gandhi, A. K., Apollonio, B., Fanous, M., Papazoglou, D., Sutton, L-A., Rosenquist, R., Amini, R-M., Chiu, H., Lopez-Girona, A., Janardhanan, P., Awan, F. T., Jones, J., Kay, N. E., Shanafelt, T. D., Tallman, M. S., Stamatopoulos, K., Patten, P. E. M. & 2 others, Vardi, A. & Ramsay, A. G., 14 Jan 2021, In: Blood. 137, 2, p. 216-231 16 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1182/blood.2020006073

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Despoina Papazoglou

Group lead

Dr Alan Ramsay

Reader (Associate Professor) in Lymphoma Biology

Contact us

alan.ramsay@kcl.ac.uk

Tweets by RamsayLab

Lymphoma Immunology

Members

Vitoria Meyer Cantinho Pereira

Alan Ramsay

Identifying effective combination immunotherapy and mechanisms of action (MOA) within the lymphoma tumour microenvironment (TME)

Studying the immunobiology of fibroblasts within lymphoid tissue TMEs

Clinical trial-associated correlative science to identify bio-assays/-markers for developing future personalised medicine

Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter's Trans-Formed DLBCL and Germinal Center B-Cells

Activation and expansion of T-follicular helper cells in chronic lymphocytic leukemia nurselike cell co-cultures

Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity

Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma

Targeting the tumor microenvironment in chronic lymphocytic leukemia

Immunomodulatory drugs for the treatment of b cell malignancies

ImmunoCluster provides a computational framework for the non-specialist to profile high- dimensional cytometry data

Understanding the Immune-Stroma Microenvironment in B Cell Malignancies for Effective Immunotherapy

A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice

Triggering interferon signaling in T cells with avadomide sensitizes CLL to anti-PD-L1/PD-1 immunotherapy

Group lead

Dr Alan Ramsay

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Lymphoma Immunology

Members

Identifying effective combination immunotherapy and mechanisms of action (MOA) within the lymphoma tumour microenvironment (TME)

Studying the immunobiology of fibroblasts within lymphoid tissue TMEs

Clinical trial-associated correlative science to identify bio-assays/-markers for developing future personalised medicine

Group lead

Contact us

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