Our group focuses on understanding post-transcriptional processes that modulate inflammation and infection, particularly in the context of asthma and other respiratory diseases. We are investigating the role of RNA binding proteins in regulating RNA expression and fate combining cellular, molecular and bioinformatics approaches. We also employ Frac-seq, a method that allows investigating RNA levels in the cytoplasm compared to those bound to different numbers of ribosomes. We are co-leading the establishment of the Single Cell Omics Platform (SCOP) and we are part of King’s Quantum. We also specialise in new diagnostics methods to detect the presence of pathognomonic RNAs.
We are keen on harmonization to enable better sharing of data, ideas and resources. To this end, we are the founders of the Clinical Diagnostics Development Unit, the CDDU, where we want to create a space to bridge discovery science and clinical implementation.