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Mishto Lab

We investigate the implications of proteasome-catalysed peptide splicing in tumour immunology, autoimmunity and in the CD8+ T cell response during infection, with the long-term aim to improve the efficacy of immunotherapy and vaccine development.

Furthermore, by applying a multi-scale and multi-disciplinary approach – thereby combining in silico, in vitro and in vivo strategies – we study how proteasome isoforms regulate the inflammation in the intracellular and extracellular space by degrading proteins and producing (pro)inflammatory peptides.

Current MSc Student:
William Scott

Funders

  1. MPI-BPC collaborative contract (2018-2019)
  2. CRUK-KHP Development fund (2018-2019)
  3. Monash-KCL Seed fund (2018-2019)
  4. KCL-Charite joint call seed fund (2019-2020)

Our partners

Cancer Research UK