We investigate the implications of proteasome-catalysed peptide splicing in tumour immunology, autoimmunity and in the CD8⁺ T cell response during infection, with the long-term aim to improve the efficacy of immunotherapy and vaccine development.

Furthermore, by applying a multi-scale and multi-disciplinary approach – thereby combining in silico, in vitro and in vivo strategies – we study how proteasome isoforms regulate the inflammation in the intracellular and extracellular space by degrading proteins and producing (pro)inflammatory peptides.

PhD students

Bei fang Teo (PhD)