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Michele Mishto
Michele Mishto

Dr Michele Mishto

Reader in Immunobiology

Research interests

  • Cancer
  • Immunology

Biography

Michele Mishto, Dr. rer. Nat. ORCHID: 0000-0003-3042-2792

Biosketch

October 2021-present Reader in Immunobiology

2017- October 2021 Senior Lecturer and group leader at Centre for Inflammation Biology and Cancer Immunology (CIBCI) & Peter Gorer Department of Immunobiology, King's College London, London, United Kingdom

2016-2017 Visiting professor at the Department of Health Sciences, Universita' del Piemonte Orientale, Novara, Italy.

2010-2017 Visiting P.I./Research Associate at the Institut für Biochemie - Charité, Berlin, Germany with funds attracted in Italy and U.S as visiting P.I.

2008-2010 Humboldt Stiftung Fellow at the Institut für Biochemie, Charité, Berlin, Germany.

2005-2008 Research Associate at Laboratory of Immunology - University of Bologna, Italy.

2001-2005 PhD fellowship at Laboratory of Immunology - University of Bologna, Italy.

2000-2001 Postgraduate fellowship at Laboratory of Immunology - University of Bologna, Italy.

Research interests

Proteasome is the core of the ubiquitin-proteasome system and responsible of the degradation of the majority of the protein in the cytosol. It is therefore involved in a large variety of metabolic pathways, including inflammation and antigen processing and presentation.

Proteasome produces fragments by canonical peptide-bond hydrolysis or by peptide splicing. Indeed, proteasome can break a protein and reshuffle its sequence by combining non-continuous fragments, thereby generating spliced peptides. By peptide splicing, proteasome significantly enlarges the antigenic landscape of a cell.

We investigate the implications of this mechanism in tumour immunology, autoimmunity and in the CD8+ T cell response during infection, with the long-term aim to improve the efficacy of immunotherapy and vaccine development.

Furthermore, by applying a multi-scale and multi-disciplinary approach – thereby combining in silico, in vitro and in vivo strategies – we study how proteasome isoforms regulate the inflammation in the intracellular and extracellular space by degrading proteins and producing (pro)inflammatory peptides.

Funds

1. CRUK Programme Foundation Award (2020-2026)

2. BRC3-IIa (2019-2022)

3. MPI-BPC Goettingen personal fund (2018-2019)

4. Development fund CRUK-KHP (2018-2019)

5. Monash-KCL Seed fund (2018-2019)

Teaching

Immunology MSc

Molecular Immunology BSc (and module organiser)

Immunology and Immunotherapy of Cancer BSc

 

    Research

    pipette 1800 x 500 banner.
    Mishto Lab

    The Mishto Lab is led by Dr Michele Mishto, Peter Gorer Department of Immunobiology

    Status not set
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    School of Immunology & Microbial Sciences: Development, Diversity & Inclusion

    The work of the Development, Diversity & Inclusion committee for the School of Immunology & Microbial Sciences

    Status not set

      Research

      pipette 1800 x 500 banner.
      Mishto Lab

      The Mishto Lab is led by Dr Michele Mishto, Peter Gorer Department of Immunobiology

      Status not set
      diversity and inclusion hands ch design csi mobil 743x496
      School of Immunology & Microbial Sciences: Development, Diversity & Inclusion

      The work of the Development, Diversity & Inclusion committee for the School of Immunology & Microbial Sciences

      Status not set