Dr Michele Mishto

Michele Mishto, Dr. rer. Nat. ORCHID: 0000-0003-3042-2792

Biosketch

October 2021-present Reader in Immunobiology

2017- October 2021 Senior Lecturer and group leader at Centre for Inflammation Biology and Cancer Immunology (CIBCI) & Peter Gorer Department of Immunobiology, King's College London, London, United Kingdom

2016-2017 Visiting professor at the Department of Health Sciences, Universita' del Piemonte Orientale, Novara, Italy.

2010-2017 Visiting P.I./Research Associate at the Institut für Biochemie - Charité, Berlin, Germany with funds attracted in Italy and U.S as visiting P.I.

2008-2010 Humboldt Stiftung Fellow at the Institut für Biochemie, Charité, Berlin, Germany.

2005-2008 Research Associate at Laboratory of Immunology - University of Bologna, Italy.

2001-2005 PhD fellowship at Laboratory of Immunology - University of Bologna, Italy.

2000-2001 Postgraduate fellowship at Laboratory of Immunology - University of Bologna, Italy.

Research interests

Proteasome is the core of the ubiquitin-proteasome system and responsible of the degradation of the majority of the protein in the cytosol. It is therefore involved in a large variety of metabolic pathways, including inflammation and antigen processing and presentation.

Proteasome produces fragments by canonical peptide-bond hydrolysis or by peptide splicing. Indeed, proteasome can break a protein and reshuffle its sequence by combining non-continuous fragments, thereby generating spliced peptides. By peptide splicing, proteasome significantly enlarges the antigenic landscape of a cell.

We investigate the implications of this mechanism in tumour immunology, autoimmunity and in the CD8+ T cell response during infection, with the long-term aim to improve the efficacy of immunotherapy and vaccine development.

Furthermore, by applying a multi-scale and multi-disciplinary approach – thereby combining in silico, in vitro and in vivo strategies – we study how proteasome isoforms regulate the inflammation in the intracellular and extracellular space by degrading proteins and producing (pro)inflammatory peptides.

Funds

1. CRUK Programme Foundation Award (2020-2026)

2. BRC3-IIa (2019-2022)

3. MPI-BPC Goettingen personal fund (2018-2019)

4. Development fund CRUK-KHP (2018-2019)

5. Monash-KCL Seed fund (2018-2019)

Teaching

Immunology MSc

Molecular Immunology BSc (and module organiser)

Immunology and Immunotherapy of Cancer BSc