Biography
Michele Mishto, Dr. rer. Nat. ORCHID: 0000-0003-3042-2792
Biosketch
October 2021-present Reader in Immunobiology
2017- October 2021 Senior Lecturer and group leader at Centre for Inflammation Biology and Cancer Immunology (CIBCI) & Peter Gorer Department of Immunobiology, King's College London, London, United Kingdom
2016-2017 Visiting professor at the Department of Health Sciences, Universita' del Piemonte Orientale, Novara, Italy.
2010-2017 Visiting P.I./Research Associate at the Institut für Biochemie - Charité, Berlin, Germany with funds attracted in Italy and U.S as visiting P.I.
2008-2010 Humboldt Stiftung Fellow at the Institut für Biochemie, Charité, Berlin, Germany.
2005-2008 Research Associate at Laboratory of Immunology - University of Bologna, Italy.
2001-2005 PhD fellowship at Laboratory of Immunology - University of Bologna, Italy.
2000-2001 Postgraduate fellowship at Laboratory of Immunology - University of Bologna, Italy.
Research interests
Proteasome is the core of the ubiquitin-proteasome system and responsible of the degradation of the majority of the protein in the cytosol. It is therefore involved in a large variety of metabolic pathways, including inflammation and antigen processing and presentation.
Proteasome produces fragments by canonical peptide-bond hydrolysis or by peptide splicing. Indeed, proteasome can break a protein and reshuffle its sequence by combining non-continuous fragments, thereby generating spliced peptides. By peptide splicing, proteasome significantly enlarges the antigenic landscape of a cell.
We investigate the implications of this mechanism in tumour immunology, autoimmunity and in the CD8+ T cell response during infection, with the long-term aim to improve the efficacy of immunotherapy and vaccine development.
Furthermore, by applying a multi-scale and multi-disciplinary approach – thereby combining in silico, in vitro and in vivo strategies – we study how proteasome isoforms regulate the inflammation in the intracellular and extracellular space by degrading proteins and producing (pro)inflammatory peptides.
Funds
1. CRUK Programme Foundation Award (2020-2026)
2. BRC3-IIa (2019-2022)
3. MPI-BPC Goettingen personal fund (2018-2019)
4. Development fund CRUK-KHP (2018-2019)
5. Monash-KCL Seed fund (2018-2019)
Teaching
Immunology MSc
Molecular Immunology BSc (and module organiser)
Immunology and Immunotherapy of Cancer BSc
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Cormican, J. A., Soh, W. T., Mishto, M. & Liepe, J., 17 Oct 2022, (E-pub ahead of print) In: Proteomics. p. 2200271 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1002/pmic.202200271
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Gutman, I., Gutman, R., Sidney, J., Chihab, L., Mishto, M., Liepe, J., Chiem, A., Greenbaum, J., Yan, Z., Sette, A., Koşaloǧlu-Yalçln, Z. & Peters, B., 12 Jul 2022, In: ACS Omega. 7, 27, p. 23771-23781 11 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1021/acsomega.2c02425
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Mishto, M., Horokhovskyi, Y., Cormican, J. A., Yang, X., Lynham, S., Urlaub, H. & Liepe, J., May 2022, In: Proteomics. 22, 10, 2100226. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1002/pmic.202100226
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Barbosa, C. R. R., Barton, J., Shepherd, A. J. & Mishto, M., Dec 2021, In: Biochemical Journal. 478, 24, p. 4187-4202 16 p. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1042/BCJ20200910
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Mishto, M., 28 Sep 2021, (Accepted/In press) In: MOLECULAR AND CELLULAR PROTEOMICS. Research output: Contribution to journal › Comment/debate › peer-review
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Mishto, M., Rodriguez-Hernandez, G., Neefjes, J., Urlaub, H. & Liepe, J., 13 Jul 2021, In: Frontiers in Immunology. 12, p. 679836 679836. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2021.679836
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Melacarne, A., Ferrari, V., Tiraboschi, L., Mishto, M., Liepe, J., Aralla, M., Marconato, L., Lizier, M., Pozzi, C., Zeira, O., Penna, G. & Rescigno, M., 6 Jul 2021, In: Cell Reports. 36, 1, 109312. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.celrep.2021.109312
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Mishto, M., Mansurkhodzhaev, A., Rodriguez-Calvo, T. & Liepe, J., 15 Apr 2021, In: Frontiers in Immunology. 12, p. 656451 656451. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2021.656451
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Mansurkhodzhaev, A., Barbosa, C. R. R., Mishto, M. & Liepe, J., 24 Feb 2021, In: Frontiers in Immunology. 12, 614276. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2021.614276
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Specht, G., Roetschke, H. P., Mansurkhodzhaev, A., Henklein, P., Textoris-Taube, K., Urlaub, H., Mishto, M. & Liepe, J., 1 Dec 2020, In: Scientific Data. 7, 1, 146. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41597-020-0487-6