Can senolytics rejuvenate the regenerative capacity of the heart Senescent cells have emerged as bona fide drivers of ageing and age-related cardiovascular disease, with senescent cells accumulating in the aged heart and following damage/injury. Removal of senescent cells using senolytics can prevent or delay tissue dysfunction, physical dysfunction and extend health- and lifespan. This project investigates the selective effects of cell senescence and senescent cell clearance on cardiomyocytes, endothelial cells and cardiac progenitor cells. The findings of this project may pave the way for the development of senolytics to treat age-related heart disorders and the toxic effects of cancer chemotherapy on the heart. The image to the left shows an increase in the number of proliferating (Ki67-positive) cardiomyocytes following senescent cell clearance by AP or D+Q senolytics in the aged mouse heart. Figure adapted from Lewis-McDougall et al. 2019, Aging Cell.