Professor Georgina Ellison-Hughes Academics Supervisors Professor of Regenerative Muscle Physiology School Academic Lead (Development, Diversity & Inclusion). Research subject areas Biomedical and life sciences Contact details georgina.ellison@kcl.ac.uk +44 (0) 20 7848 6074 @GMELLISONHUGHES
Correction to: Transplantation of Skeletal Muscle-Derived Sca-1+/PW1+/Pax7− Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction (Cells, (2022), 11, 24, (4050), 10.3390/cells11244050) Myonuclear alterations associated with exercise are independent of age in humans Transplantation of Skeletal Muscle-Derived Sca-1+/PW1+/Pax7− Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction Targeting cardiac stem cell senescence to treat cardiac aging and disease Receptor tyrosine kinase inhibitors negatively impact on pro-reparative characteristics of human cardiac progenitor cells Human primary skeletal muscle-derived myoblasts and fibroblasts reveal different senescent phenotypes Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age A protocol for extracting immunolabeled murine cardiomyocytes of high-quality RNA by laser capture microdissection Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms Vascular Manifestations of COVID-19 – Thromboembolism and Microvascular Dysfunction Cardiac Stem Cells for Myocardial Regeneration: They Are Not Alone Senescent cells: targeting and therapeutic potential of senolytics in age-related diseases with particular focus on the heart Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia Atrial Myxomas Arise From Multipotent Cardiac Stem Cells c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration Aged-senescent cells contribute to impaired heart regeneration Response to Molkentin's letter to the editor regarding article, "the absence of evidence is not evidence of absence: the pitfalls of Cre knock-ins in the c-kit locus" Basic science behind the cardiovascular benefits of exercise Basic science behind the cardiovascular benefits of exercise Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle Non-invasive strategies for stimulating endogenous repair and regenerative mechanisms in the damaged heart Skeletal muscle-derived interstitialprogenitor cells (PICs) display stem cellproperties, being clonogenic, self-renewing,and multi-potent in vitro and in vivo Cardiac adaptations from 4 weeks of intensity-controlled vigorous exercise are lost after a similar period of detraining. Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery Adult c-kitpos cardiac stem cells fulfill koch's postulates as causal agents for cardiac regeneration Absence of evidence is not evidence of absence: Pitfalls of cre knock-ins in the c-kit locus The cardiac stem cell compartment is indispensable for myocardial cell homeostasis, repair and regeneration in the adult Basic science behind the cardiovascular benefits of exercise Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart Porcine Skeletal Muscle-Derived Multipotent PW1(pos)/Pax7(neg) Interstitial Cells: Isolation, Characterization, and Long-Term Culture Carbonic Anhydrase Activation Is Associated With Worsened Pathological Remodeling in Human Ischemic Diabetic Cardiomyopathy Sustained Delivery of Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Stimulates Endogenous Cardiac Repair in the Chronic Infarcted Pig Heart Concise Review: Heart Regeneration and the Role of Cardiac Stem Cells MicroRNA-1 Downregulation Increases Connexin 43 Displacement and Induces Ventricular Tachyarrhythmias in Rodent Hypertrophic Hearts Aging exacerbates negative remodeling and impairs endothelial regeneration after balloon injury Catecholamine-induced apoptosis and necrosis in cardiac and skeletal myocytes of the rat in vivo: the same or separate death pathways? Increased vascular endothelial growth factor expression but impaired vascular endothelial growth factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary heart disease Cardiac Stem and Progenitor Cell Biology for Regenerative Medicine Relative Toxicity of Cardiotonic Agents: Some Induce More Cardiac and Skeletal Myocyte Apoptosis and Necrosis In Vivo Than Others Resident progenitors and bone marrow stem cells in myocardial renewal and repair Isolation and Expansion of Cardiosphere-Derived Stem Cells Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration Cardiovascular Regenerative Medicine at the Crossroads. Clinical Trials of Cellular Therapy Must Now Be Based on Reliable Experimental Data From Animals With Characteristics Similar to Human's Cardiovascular development: towards biomedical applicability: Resident cardiac stem cells Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair Testing regeneration of human myocardium without knowing the identity and the number of effective bone marrow cells transplanted: are the results meaningful? Growth-factor-mediated cardiac stem cell activation in myocardial regeneration Myocyte death and renewal: modern concepts of cardiac cellular homeostasis Acute β-Adrenergic Overload Produces Myocyte Damage through Calcium Leakage from the Ryanodine Receptor 2 but Spares Cardiac Stem Cells View all publications
20 April 2023 New group of drugs found to eliminate 'zombie' cells associated with cardiovascular disease Researchers show that use of senolytics can improve the reparative properties of human heart cells…